Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer.

scientific article published on 13 January 2014

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer. is …
instance of (P31):
scholarly articleQ13442814
meta-analysisQ815382

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P6179Dimensions Publication ID1015995141
P356DOI10.1186/1471-2407-14-16
P932PMC publication ID3897978
P698PubMed publication ID24418414
P5875ResearchGate publication ID259719473

P50authorShyh-han TanQ43195755
Gyorgy PetrovicsQ82992945
P2093author name stringShiv Srivastava
Albert Dobi
Ahmed A Mohamed
Shilpa Katta
Francisco Saenz
Rajesh Thangapazham
P2860cites workETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancerQ21091136
The erg gene: a human gene related to the ets oncogeneQ24299030
NKX3.1 activates cellular response to DNA damageQ24306760
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesisQ24314483
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3Q24316419
Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1Q24337092
A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate glandQ24646455
The mutational landscape of prostate cancerQ26851631
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Q27824849
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translationQ28295357
MatInspector and beyond: promoter analysis based on transcription factor binding sitesQ29616314
Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptomeQ33212600
Delineation of TMPRSS2-ERG splice variants in prostate cancerQ33357287
CFTR is a negative regulator of NFkappaB mediated innate immune responseQ33413105
MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cellsQ33535955
Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status.Q33645816
Loss of Nkx3.1 expression in bacterial prostatitis: a potential link between inflammation and neoplasiaQ33816335
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.Q33873888
Antibody-based detection of ERG rearrangement-positive prostate cancerQ34009867
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.Q34014956
NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.Q34111030
Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesisQ34786771
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancerQ35559975
Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survivalQ35665662
Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesisQ35913655
Deciphering modular and dynamic behaviors of transcriptional networksQ36513574
ETS rearrangements in prostate cancerQ37047029
Recurrent gene fusions in prostate cancerQ37194503
ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cellsQ37257659
Transcription factors: from enhancer binding to developmental controlQ38032407
Recurrent gene fusions in prostate cancer: their clinical implications and usesQ38102618
A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growthQ38299437
CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.Q38317100
A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes.Q38820147
Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I.Q39171279
Inflammation-mediated abrogation of androgen signaling: an in vitro model of prostate cell inflammation.Q39293318
ERG oncogene modulates prostaglandin signaling in prostate cancer cells.Q39616982
Coactivator selective regulation of androgen receptor activityQ39848118
TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cellsQ39858177
Androgen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell linesQ39868664
A role for DNA methylation in regulating the growth suppressor PMEPA1 gene in prostate cancerQ40028399
Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancerQ40028950
Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.Q40604496
ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratificationQ41489983
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesisQ41778982
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastasesQ44521056
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.Q44590758
Androgen receptor binding sites identified by a GREF_GATA modelQ46742780
Expression of SLC26A3, CFTR and NHE3 in the human male reproductive tract: role in male subfertility caused by congenital chloride diarrhoea.Q52568330
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.Q54529505
The promoter connectionQ74592018
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)16
P577publication date2014-01-13
P1433published inBMC CancerQ326300
P1476titleLoss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer
P478volume14