The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

scientific article published on May 15, 1991

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1991PNAS...88.4404K
P356DOI10.1073/PNAS.88.10.4404
P953full work available at URLhttps://europepmc.org/articles/PMC51668
https://europepmc.org/articles/PMC51668?pdf=render
https://pnas.org/doi/pdf/10.1073/pnas.88.10.4404
P932PMC publication ID51668
P698PubMed publication ID1852007
P5875ResearchGate publication ID21303991

P50authorThomas KjeldsenQ97904799
P2093author name stringN. P. Møller
L. Schäffer
K. B. Møller
P. Balschmidt
A. S. Andersen
F. C. Wiberg
J. S. Rasmussen
P2860cites workSignal transduction by receptors with tyrosine kinase activityQ27860624
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signallingQ28615445
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesQ28615460
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extensionQ29547330
Properties of the insulin receptor ectodomainQ33654340
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificityQ33880454
After insulin bindsQ34398025
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificityQ34681325
Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation-sephadex)Q34687180
Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometriesQ36418320
Signal transmission by the insulin-like growth factorsQ38297337
The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimerasQ38338637
Mutation of the high cysteine region of the human insulin receptor alpha-subunit increases insulin receptor binding affinity and transmembrane signaling.Q38343582
The molecular mechanism of insulin actionQ39494087
Molecular analysis of signal transduction by growth factorsQ39650738
The insulin receptor: molecular biology and transmembrane signalingQ39669588
Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.Q40817131
Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domainsQ40817837
Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltonsQ41499132
Changing the insulin receptor to possess insulin-like growth factor I ligand specificityQ41725096
Secretion of soluble functional insulin receptors by transfected NIH3T3 cells.Q41817388
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosineQ42448440
Hormone binding site of the insulin receptor: analysis using photoaffinity-mediated avidin complexing.Q43552054
Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunitQ44976319
Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the geneQ46089104
Interaction of concanavalin A and wheat germ agglutinin with the insulin receptor of fat cells and liver.Q53793776
Molecular Basis of Insulin ActionQ66847247
Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membraneQ67294635
Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/bindingQ69647871
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptorQ70199323
Truncation of the ectodomain of the human insulin receptor results in secretion of a soluble insulin binding protein from transfected CHO cellsQ70273192
The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptorQ72926701
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)4404-4408
P577publication date1991-05-01
1991-05-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site
P478volume88

Reverse relations

cites work (P2860)
Q33383201A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.
Q38330508A deletion in the extracellular domain of the alpha platelet-derived growth factor (PDGF) receptor differentially impairs PDGF-AA and PDGF-BB binding affinities
Q37614858A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies
Q42176585A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor
Q24304168Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction
Q43704238Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site
Q24608585Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I
Q58024148An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors
Q41335748Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes
Q28473411Cloning and characterisation of Schistosoma japonicum insulin receptors
Q27764901Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor
Q43126193Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains
Q54182696Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.
Q47823208Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni.
Q28744380Engineering of insulin receptor isoform-selective insulin analogues
Q51140407Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice.
Q38335851Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.
Q41128080Growth promoting and metabolic activity of the human insulin analogue [GlyA21,ArgB31,ArgB32]insulin (HOE 901) in muscle cells
Q41098705Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding
Q42804380Identification of determinants that confer ligand specificity on the insulin receptor
Q40491200Insulin and Insulin‐like Growth Factor‐I Induced Phosphorylation in Neurally Derived Cells
Q68184725Insulin receptors are bivalent as demonstrated by photoaffinity labeling
Q36479917Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling
Q40491208Insulin‐like Growth Factor Receptors: Implications for Nervous System Function
Q36678155Interspecies molecular chimeras of kit help define the binding site of the stem cell factor
Q36730813Molecular cloning and biochemical characterization of a receptor-like serine/threonine kinase from rice
Q40821663Molecular defects of insulin/IGF-1 receptor transmembrane signaling
Q40438858Molecular defects of the insulin receptor gene
Q34268894Multiple signal transduction pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase in normal and tumoral target tissues
Q24298540Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1
Q39709669Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor
Q47930345Positive selection has driven the evolution of the Drosophila insulin-like receptor (InR) at different timescales
Q73526060Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region
Q71743301Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation
Q24322837Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
Q24602369Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
Q36736100Regulation of muscle mass by growth hormone and IGF-I.
Q38291436Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin
Q38322445Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants
Q28297758Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor
Q41891400Solution structure of a mini IGF-1
Q34387886Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
Q73280020Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit
Q34152764Structural biology of insulin and IGF1 receptors: implications for drug design
Q41727239Structure and function of the insulin-like growth factor I receptor
Q40490475Structure-function analyses of the kit receptor for the steel factor
Q28731843Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues
Q38297918The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction
Q34944353The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity
Q35228056The insulin‐binding domain of insulin receptor is encoded by exon 2 and exon 3
Q34243964The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1).
Q35094666The role of receptor tyrosine kinase inhibition in treating gastrointestinal malignancy
Q28678337The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis
Q34315974The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.
Q28365954The three dimensional structure of the type I insulin-like growth factor receptor
Q38354696Theoretical and computational studies of peptides and receptors of the insulin family
Q64234705Thyroid Abnormalities in Patients With Extreme Insulin Resistance Syndromes
Q35012773Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells
Q34348691Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer : future possibilities for personalised treatment by use of biomarkers