Activation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats

scientific article published on 15 December 2016

Activation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID5209508
P698PubMed publication ID28078028

P2093author name stringYu Chen
Rui Fu
Ming-Xian Chen
Qin-Qin Yang
Sai-Yue Liu
Tang-Biao Shen
P2860cites workThe role of visceral hypersensitivity in irritable bowel syndrome: pharmacological targets and novel treatmentsQ26739291
A role of periaqueductal grey NR2B-containing NMDA receptor in mediating persistent inflammatory painQ33578684
Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings.Q33851444
Central and peripheral hypersensitivity in the irritable bowel syndrome.Q34033753
Review article: the economic impact of the irritable bowel syndromeQ34041951
Irritable bowel syndrome: new agents targeting serotonin receptor subtypesQ34212885
Epidemiology of irritable bowel syndrome in Asia: something old, something new, something borrowedQ34612294
Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat modelQ35165975
Pathophysiologic findings of irritable bowel syndrome in chinaQ35730488
Irritable bowel syndrome: a model of the brain-gut interactionsQ35839435
Neuromodulatory processes of the brain-gut axisQ37390659
Infection, inflammation, and the irritable bowel syndromeQ37589116
Mechanisms underlying visceral hypersensitivity in irritable bowel syndromeQ37871421
Physiological, pathophysiological and therapeutic impact of the enteric serotonergic systemQ37995969
Altered neuro-endocrine-immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model.Q38024260
Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndromeQ38178543
Underlying molecular and cellular mechanisms in childhood irritable bowel syndromeQ38515695
Downregulation of the spinal NMDA receptor NR2B subunit during electro-acupuncture relief of chronic visceral hyperalgesiaQ39172190
Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trialsQ39397861
Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptakeQ40374840
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.Q42462847
Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley ratsQ42844036
Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndromeQ43746131
T-cell activation in patients with irritable bowel syndromeQ43864301
Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord contributes to chronic visceral pain in ratsQ44762084
Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic painQ45815924
Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndromeQ46431252
Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndromeQ46885942
Spinal cord long-term potentiation is attenuated by the NMDA-2B receptor antagonist Ro 25-6981.Q46923513
Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?Q46939907
Imbalance of tumor necrosis factor-α, interleukin-8 and interleukin-10 production evokes barrier dysfunction, severe abdominal symptoms and psychological disorders in patients with irritable bowel syndrome-associated diarrheaQ48078265
A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal developmentQ73130772
Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoffQ84145763
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectirritable bowel syndromeQ838966
P304page(s)5580-5590
P577publication date2016-12-15
P1433published inAmerican Journal of Translational ResearchQ4744272
P1476titleActivation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats
P478volume8

Reverse relations

cites work (P2860)
Q48335208Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor
Q64248522Effect of Electroacupuncture at Different Acupoints on the Expression of NMDA Receptors in ACC and Colon in IBS Rats
Q57819633MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats

Search more.