Role of sox9 in growth factor regulation of articular chondrocytes

scientific article published on July 2015

Role of sox9 in growth factor regulation of articular chondrocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCB.25099
P932PMC publication ID5210171
P698PubMed publication ID25708223

P2093author name stringCongrong Wang
George J Eckert
Shuiliang Shi
Stephen B Trippel
Anthony J Acton
P2860cites workCollagen of articular cartilageQ24805941
Bone morphogenetic proteinsQ28300236
Distribution of the transcription factors Sox9, AP-2, and [delta]EF1 in adult murine articular and meniscal cartilage and growth plateQ28511841
SOX9 directly regulates the type-II collagen geneQ28512288
Sox9 is required for cartilage formationQ28588649
SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes.Q31154716
Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytesQ33953872
Transcriptional mechanisms of chondrocyte differentiationQ34026877
IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathwayQ34110239
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathwayQ35006524
Transcriptional control of chondrocyte fate and differentiationQ36269368
The postnatal role of Sox9 in cartilageQ36412996
OP-1/BMP-7 in cartilage repairQ36905511
Growth factor transgenes interactively regulate articular chondrocytesQ37715441
Unraveling the transcriptional regulatory machinery in chondrogenesisQ37877164
Fibroblast growth factor control of cartilage homeostasisQ38051582
Growth factor actions on articular cartilageQ40526506
SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.Q40831754
Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transferQ41915703
Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explantsQ42505298
Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explantsQ43783103
Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivoQ43841888
Insulin-like growth factor-I enhances cell-based repair of articular cartilageQ43939255
The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytesQ44541021
Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transferQ44606527
Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantationQ44773219
Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.Q44777062
Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoterQ44891638
Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture.Q45008815
Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vectorQ45527212
Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine modelQ45868543
Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantationQ45880338
Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I).Q45882616
Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotypeQ46528952
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcriptionQ46629634
Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beadsQ47286014
Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivoQ48010592
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.Q52211686
Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: Molecular association between Sox9 and Erk1/2Q58629420
Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in cultureQ59072051
Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9Q64377343
Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytesQ71766997
Recombinant human bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term cultureQ71941711
Transrepression of type II collagen by TGF-beta and FGF is protein kinase C dependent and is mediated through regulatory sequences in the promoter and first intronQ72661879
SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation stateQ73314811
Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in a transgenic mouse model of osteoarthritisQ73792183
Articular cartilage repair and transplantationQ77093059
Beneficial effect of basic fibroblast growth factor on the repair of full-thickness defects in rabbit articular cartilageQ77957320
Similarities and differences between insulin and IGF-I: structures, receptors, and signalling pathwaysQ81238507
Promotion of the intrinsic damage-repair response in articular cartilage by fibroblastic growth factor-2Q81794212
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1391-1400
P577publication date2015-07-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleRole of sox9 in growth factor regulation of articular chondrocytes
P478volume116