A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

scientific article published on January 2014

A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S13346-013-0180-9
P932PMC publication ID3918124
P698PubMed publication ID24533256
P5875ResearchGate publication ID258168925

P50authorTakahiro OchiyaQ89401456
Nobuyoshi KosakaQ96136390
Keitaro HagiwaraQ114452528
P2860cites workExfoliation of membrane ecto-enzymes in the form of micro-vesiclesQ55490241
Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressiveQ64378279
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Secreted monocytic miR-150 enhances targeted endothelial cell migrationQ84525686
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Secretory mechanisms and intercellular transfer of microRNAs in living cellsQ24603413
Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genesQ24628676
MicroRNA-210 as a novel therapy for treatment of ischemic heart diseaseQ24633429
Circulating microRNAs as stable blood-based markers for cancer detectionQ24652098
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer modelQ24655262
B lymphocytes secrete antigen-presenting vesiclesQ24678522
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microRNA as a new immune-regulatory agent in breast milkQ27499226
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansQ27860867
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesQ28131780
ExoCarta: A compendium of exosomal proteins and RNAQ28260686
Exosomes derived from HIV-1-infected cells contain trans-activation response element RNAQ28290390
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomesQ29617554
The MicroRNA Spectrum in 12 Body FluidsQ29618068
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomesQ29619437
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Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-primingQ33936302
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesiclesQ34026858
A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomesQ34122290
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Exosome can prevent RNase from degrading microRNA in fecesQ36097215
Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes.Q36280594
Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cellsQ36512528
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasisQ36760424
A pathogenic picornavirus acquires an envelope by hijacking cellular membranesQ36781367
Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1.Q36929092
Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injectionQ39170295
Microvesicle-associated AAV vector as a novel gene delivery systemQ39400043
Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi).Q39422321
Cellular internalization of exosomes occurs through phagocytosisQ39742924
Microenvironmental pH is a key factor for exosome traffic in tumor cellsQ39791777
Discrimination between exosomes and HIV-1: purification of both vesicles from cell-free supernatantsQ39954819
Increased exosome production from tumour cell cultures using the Integra CELLine Culture System.Q39990629
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cellsQ40735249
Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of PhosphatidylserineQ41267214
Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytesQ41479630
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters.Q42680541
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complexQ43925949
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles.Q44889447
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAsQ45147309
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation stateQ45872960
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophagesQ46219107
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cellsQ48362692
Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopyQ48811468
P275copyright licenseCreative Commons Attribution-NonCommercial 2.0 GenericQ44128984
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectextracellular vesicleQ21097485
paradigm shiftQ689971
P304page(s)31-37
P577publication date2014-01-01
P1433published inDrug delivery and translational researchQ27723621
P1476titleA paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
P478volume4

Reverse relations

cites work (P2860)
Q30652180Biodistribution and function of extracellular miRNA-155 in mice
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Q92187720Extracellular Vesicles Derived From Olfactory Ensheathing Cells Promote Peripheral Nerve Regeneration in Rats
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