The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage

scientific article published on September 1991

The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1991PNAS...88.7464D
P356DOI10.1073/PNAS.88.17.7464
P932PMC publication ID52320
P698PubMed publication ID1881884
P5875ResearchGate publication ID21273871

P50authorDonald CrothersQ15979677
P2093author name stringS Danishefsky
J Drak
N Iwasawa
P2860cites workBinding of Hoechst 33258 to the minor groove of B-DNAQ27688967
Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322.Q33836505
Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibioticsQ34309723
Sequence-specific recognition of double helical nucleic acids by proteinsQ35987597
DNA double-strand breaks and alkali-labile bonds produced by bleomycinQ36186266
Bleomycin-specific fragmentation of double-stranded DNA.Q39490445
DNA structure and perturbation by drug bindingQ39510318
DNA sequence specificity of mitomycin cross-linkingQ57260357
Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specificallyQ60305554
Sequence-specific double-strand breakage of DNA by neocarzinostatin involves different chemical mechanisms within a staggered cleavage siteQ64390033
Solution structure of the chromomycin-DNA complexQ69596816
Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificityQ69604954
Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analysesQ70500973
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)7464-7468
P577publication date1991-09-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage
P478volume88

Reverse relations

cites work (P2860)
Q43653145A series of enediynes as novel inhibitors of topoisomerase I.
Q33779886Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove
Q24562475Chemistry and biology of natural and designed enediynes
Q24561724Cleavage behavior of calicheamicin gamma 1 and calicheamicin T
Q35690179Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution
Q41623727Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity
Q67470988Engineering Antibodies for Therapy
Q90438199Gemtuzumab ozogamicin for treatment of newly diagnosed CD33-positive acute myeloid leukemia
Q39218600Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis
Q52184933Humanized antibodies as potential therapeutic drugs.
Q35909309Immunotoxins and toxin constructs in the treatment of leukemia and lymphoma
Q60915299Inotuzumab: from preclinical development to success in B-cell acute lymphoblastic leukemia
Q35627787Interaction of calicheamicin gamma1(I) and its related carbohydrates with DNA-protein complexes
Q37224944Intervention of carbohydrate recognition by proteins and nucleic acids
Q36202066Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner
Q41188568Mechanisms of target selection by DNA-damaging chemicals: studies with enediyne anticancer drugs
Q37814157Natural glycoconjugates with antitumor activity
Q56979491Novel insights on the DNA interaction of calicheamicin γ1I
Q35771242Organic synthesis and cell biology: partners in controlling gene expression
Q37809500Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis
Q72707290Regulation of apoptosis in leukemic cells by analogs of dynemicin A
Q36471589Simultaneous determination of helical unwinding angles and intrinsic association constants in ligand-DNA complexes: the interaction between DNA and calichearubicin B.
Q35771896Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists
Q37907992Structural and conformational features relevant to the anti-tumor activity of calicheamicin γ 1I.
Q33266307The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.
Q33877323The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.
Q77732327Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin gamma(I)(1)
Q38303120Use of triethylene glycol to mimic oligosaccharides: design and synthesis of a ligand based on chromomycin A3.