Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects

scientific article published on 19 January 2017

Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1053954138
P356DOI10.1186/S13014-016-0750-3
P932PMC publication ID5251326
P698PubMed publication ID28107823

P50authorCarsten HerskindQ42703099
P2093author name stringLin Ma
Bo Zhang
Frank Schneider
Qi Liu
Frederik Wenz
Marlon R Veldwijk
P2860cites workEvidence for formation of DNA repair centers and dose-response nonlinearity in human cellsQ24609012
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray dosesQ24677973
Multicentricity of breast cancer: whole-organ analysis and clinical implicationsQ24679799
Accelerated Partial Breast Irradiation in Clinical PracticeQ26776283
The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?Q26823489
Intraoperative Electron Radiotherapy (IOERT) as an Alternative to Standard Whole Breast Irradiation: Only for Low-Risk Subgroups?Q26864258
Treatment of Breast and Prostate Cancer by Hypofractionated Radiotherapy: Potential Risks and BenefitsQ26998991
Factors determining DNA double-strand break repair pathway choice in G2 phaseQ28118755
Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A.Q49109112
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.Q49165929
Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.Q50754518
No significant endothelial apoptosis in the radiation-induced gastrointestinal syndrome.Q51021200
Radiation-induced lung damage after thoracic irradiation for Hodgkin's disease: the role of fractionation.Q51047696
Survival and tumour control probability in tumours with heterogeneous oxygenation: a comparison between the linear-quadratic and the universal survival curve models for high doses.Q51074850
Soft X-ray dosimetry and RBE for survival of Chinese hamster V79 cells.Q51608357
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts.Q51630517
Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines.Q51820892
Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays.Q51834143
A new incomplete-repair model based on a 'reciprocal-time' pattern of sublethal damage repair.Q52132284
The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships.Q52240518
Repair kinetics in pig epidermis: an analysis based on two separate rates of repair.Q52320154
An integrated logistic formula for prediction of complications from radiosurgery.Q52519196
Recovery kinetics deduced from continuous low dose-rate experiments.Q52535838
An 'incomplete-repair' model for survival after fractionated and continuous irradiations.Q52675324
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation.Q53304915
Dosimetric characterization of INTRABEAM® miniature accelerator flat and surface applicators for dermatologic applications.Q53311760
Toward a unified survival curve: in regard to Park et al. (IntJ Radiat Oncol Biol Phys 2008;70:847-852) and Krueger et al. (Int J Radiat Oncol Biol Phys 2007;69:1262-1271).Q53538861
Accelerated partial breast irradiation with intraoperative electrons: using GEC-ESTRO recommendations as guidance for patient selection.Q53756743
Local Recurrences and Distant Metastases After Conservative Breast Cancer Treatments: Partly Independent EventsQ54145502
No apoptotic endothelial cells in irradiated intestine: regarding Schuller et al. (Int J Radiat Oncol Biol Phys 2007;68:205-210).Q54587550
Preclinical studies with the photon radiosurgery system (PRS).Q55475597
Engaging the vascular component of the tumor responseQ57359877
Relationship between early and late normal-tissue injury after postmastectomy radiotherapyQ57618722
The Linear-Quadratic Model Is Inappropriate to Model High Dose per Fraction Effects in RadiosurgeryQ57730424
Complications from arteriovenous malformation radiosurgery: Multivariate analysis and risk modelingQ61832821
Split Dose Recovery Studies using Homologous Recombination Deficient Gene Knockout Chicken B Lymphocyte CellsQ63965559
DNA repair in the context of chromatin: new molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopyQ64386909
Induction of DNA strand breaks, base lesions and clustered damage sites in hydrated plasmid DNA films by ultrasoft X rays around the phosphorus K edgeQ64387311
Lethal and potentially lethal lesions induced by radiation--a unified repair modelQ64390425
Radiobiology of ultrasoft X rays. I. Cultured hamster cells (V79)Q69039629
Induction of chromosome aberrations in human lymphocytes by monochromatic X-rays of quantum energy between 4.8 and 14.6 keVQ69376922
RBE of 20 kV and 70 kV X-rays determined for survival of V 79 cellsQ69674838
Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation, and telangiectasia after 3 and 5 year's follow-upQ69685712
Saturable repair models of radiation action in mammalian cellsQ69853231
Recovery from radiation damage in mouse lung: interpretation in terms of two rates of repairQ70572133
Tumor response to radiotherapy regulated by endothelial cell apoptosisQ73401346
Predicting realistic RBE values for clinically relevant radiotherapy schedulesQ73562848
Ectopic expression of a COOH-terminal fragment of the human telomerase reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in HeLa cellsQ74198983
Electron spectra and the RBE of X raysQ74318140
Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devicesQ74592446
The role of cytokines in the development of normal-tissue reactions after radiotherapyQ77606033
Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancerQ79610923
Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapyQ81063080
Radiobiological aspects of intraoperative radiotherapy (IORT) with isotropic low-energy X rays for early-stage breast cancerQ81294143
Sphere of equivalence--a novel target volume concept for intraoperative radiotherapy using low-energy X raysQ82700981
A dosimetric comparison of IORT techniques in limited-stage breast cancerQ83351847
A novel device for intravaginal electronic brachytherapyQ84104826
Radiobiological comparison of hypofractionated accelerated partial-breast irradiation (APBI) and single-dose intraoperative radiotherapy (IORT) with 50-kV X-raysQ84965684
Breast-conserving surgery and intraoperative electron radiotherapy in early breast cancer: experience at the Rambam Health Care CampusQ85279221
Are mammographic changes in the tumor bed more pronounced after intraoperative radiotherapy for breast cancer? Subgroup analysis from a randomized trial (TARGIT-A)Q85507909
Do we need "biology-based" models to describe cell survival curves after exposure to ionizing radiation?Q86581480
IOERT as anticipated tumor bed boost during breast-conserving surgery after neoadjuvant chemotherapy in locally advanced breast cancer--results of a case series after 5-year follow-upQ88218008
Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical woundingQ28271265
Pathways of DNA double-strand break repair during the mammalian cell cycleQ28608969
A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report.Q30733408
12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumorsQ33225216
Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancerQ33354322
Single-Center Long-Term Follow-Up After Intraoperative Radiotherapy as a Boost During Breast-Conserving Surgery Using Low-Kilovoltage X-RaysQ33696000
Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joiningQ33698679
Quantitative clinical radiobiology of early and late lung reactionsQ33921090
Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgeryQ34144051
Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.Q34232527
Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopyQ34292873
Intraoperative radiation therapy: a critical analysis of the ELIOT and TARGIT trials. Part 1--ELIOT.Q34303451
Intraoperative radiation therapy: a critical analysis of the ELIOT and TARGIT trials. Part 2--TARGITQ34303459
A Monte Carlo based source model for dose calculation of endovaginal TARGIT brachytherapy with INTRABEAM and a cylindrical applicator.Q34319186
Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trialQ34384718
In vivo optical imaging of tumor and microvascular response to ionizing radiationQ34395430
Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cellsQ34410739
Relative Biologic Effectiveness (RBE) of 50 kV X-rays measured in a phantom for intraoperative tumor-bed irradiationQ34415285
Cathepsin L activity controls adipogenesis and glucose toleranceQ34654358
Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.Q34728634
ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombinationQ34917270
Does delay in starting treatment affect the outcomes of radiotherapy? A systematic reviewQ35057465
INTRAGO: intraoperative radiotherapy in glioblastoma multiforme—a phase I/II dose escalation studyQ35189570
Radiation and ceramide-induced apoptosisQ35208833
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymesQ35633868
Mechanisms of DNA double strand break repair and chromosome aberration formationQ35783199
The kinetics of repair for sublethal radiation-induced damage in the pig epidermis: an interpretation based on a fast and a slow component of repairQ35907304
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in miceQ35913691
Glycosphingolipids and cell death: one aim, many waysQ36405917
Radiation dose-volume effects in the brain.Q36560171
Ku-dependent non-homologous end-joining as the major pathway contributes to sublethal damage repair in mammalian cellsQ36565430
Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated radiation doses to single dosesQ36661372
The shape of the radiation dose response for DNA double-strand break induction and repair.Q36741205
Cell kinetics.Q36776433
Clinical aspects of intraoperative radiotherapy in early breast cancer: short-term complications after IORT in women treated with low energy x-rays.Q36814821
The relationship between waiting time for radiotherapy and clinical outcomes: a systematic review of the literatureQ37045313
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatinQ37261069
The biological effect of large single doses: a possible role for non-targeted effects in cell inactivationQ37504688
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organizationQ37634166
Dose-rate effects in external beam radiotherapy reduxQ37723716
RBE of low energy electrons and photonsQ37739092
The role of homologous recombination in radiation-induced double-strand break repairQ37898827
Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS).Q37974257
Cancer stem cells as a predictive factor in radiotherapyQ37990114
Research opportunities in intraoperative radiation therapy: the next decade 2013-2023.Q38086807
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapyQ38106985
Present status and future directions of intraoperative radiotherapyQ38147542
Intraoperative radiation therapy techniques and options for breast cancerQ38193576
DNA double-strand break repair in a cellular contextQ38196085
ATM regulates target switching to escalating doses of radiation in the intestinesQ38327055
The Nuclear Factor κB pathway: A link to the immune system in the radiation responseQ38358248
The radiobiology of hypofractionation.Q38386825
Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations.Q38621168
Prolongation of overall treatment time as a cause of treatment failure in early breast cancer: An analysis of the UK START (Standardisation of Breast Radiotherapy) trials of radiotherapy fractionation.Q39352887
Characteristic 8 keV X rays possess radiobiological properties of higher-LET radiation.Q39732778
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimizationQ39742371
Fitting techniques of cell survival curves in high-dose region for use in stereotactic body radiation therapyQ39881919
In vitro determination of radiation sensitivity parameters for DU-145 prostate cancer cellsQ39983637
Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapyQ40014973
Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: results for cells deficient in nonhomologous end joiningQ40663153
Weiss Lecture. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repairQ40710240
Cell inactivation and double-strand breaks: the role of core ionizations, as probed by ultrasoft X rays.Q40752057
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.Q40799711
Requirement for repair of DNA double-strand breaks by homologous recombination in split-dose recoveryQ40812740
The relative biological effectiveness of 60Co gamma-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low dosesQ41638236
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formationQ41874223
The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fractionQ41879769
Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trialQ43427825
IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysisQ43470885
A generalized linear-quadratic model incorporating reciprocal time pattern of radiation damage repairQ43733947
Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trialQ44401637
The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 "boost versus no boost" trialQ44653649
The 5Rs of radiobiologyQ44952713
The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials.Q46425805
A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapyQ46540508
Normal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials.Q46858839
Radiobiological analysis of tissue responses following radiosurgeryQ47984270
Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgeryQ48448781
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectneoplasmQ1216998
intraoperative radiation therapyQ3928881
dose fractionationQ5299253
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)24
P577publication date2017-01-19
P1433published inRadiation OncologyQ2313370
P1476titleBiology of high single doses of IORT: RBE, 5 R's, and other biological aspects
P478volume12

Reverse relations

cites work (P2860)
Q92862781Enhancing the Bystander and Abscopal Effects to Improve Radiotherapy Outcomes
Q87944374Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies
Q38632924Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection
Q57110198Intraoperative Electron Radiotherapy (IOERT) in the Treatment of Primary Breast Cancer
Q39453639Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer
Q89586369Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth
Q38648229Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting : Current and Future Application of Intraoperative Radiotherapy (IORT) in the Curative and Palliative Treatment of Breast Cancer
Q90066381Outcomes of immediate oncoplastic surgery and adjuvant radiotherapy in breast cancer patients
Q58587457Radiation Therapy Reduced Blood Levels of LDH, HIF-1α, and miR-210 in OSCC
Q92306377Radioimmunotherapy for the treatment of head and neck cancer
Q90376845Radiotherapy, tumor mutational burden, and immune checkpoint inhibitors: time to do the math

Search more.