The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.

scientific article published on 09 December 2016

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2016.11.013
P932PMC publication ID5266791
P698PubMed publication ID27986592

P50authorAndrew J DeansQ51006443
Ambrosius P. SnijdersQ38319805
Ludovic RenaultQ42846004
Paolo SwuecQ51006434
P2093author name stringFenil Shah
Alessandro Costa
Sylvie van Twest
Vincent J Murphy
Aaron Borg
P2860cites workMolecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic AcidQ1895685
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitinationQ22010577
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulationQ24300065
FANCI is a second monoubiquitinated member of the Fanconi anemia pathwayQ24303906
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stabilityQ24304973
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCIQ24311413
FANCE: the link between Fanconi anaemia complex assembly and activityQ24534972
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repairQ24685928
Structure of a BRCA1-BARD1 heterodimeric RING-RING complexQ27635007
Insights into Fanconi Anaemia from the structure of human FANCEQ27643858
The structure of the catalytic subunit FANCL of the Fanconi anemia core complexQ27659847
RING domain dimerization is essential for RNF4 functionQ27663855
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair PathwayQ27670826
Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia PathwayQ27670898
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.Q27677990
Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 ComplexQ27679490
Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 SelectionQ27681171
Structure of the eukaryotic MCM complex at 3.8 ÅQ27701671
Retroviral Integrase Structure and DNA Recombination Mechanism.Q53836302
SnapShot: Fanconi anemia and associated proteins.Q55058813
Structure of the nucleosome core particle at 7 Å resolutionQ56337256
The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3Q27701751
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Accurate determination of local defocus and specimen tilt in electron microscopyQ27861008
EMAN2: an extensible image processing suite for electron microscopyQ27861052
Integrated structural analysis of the human nuclear pore complex scaffoldQ28115760
Positional cloning of a novel Fanconi anemia gene, FANCD2Q28203761
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayQ28203777
A novel ubiquitin ligase is deficient in Fanconi anemiaQ28206919
FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathwayQ28269431
Fanconi anaemia and the repair of Watson and Crick DNA crosslinksQ28283549
RELION: implementation of a Bayesian approach to cryo-EM structure determinationQ29547673
Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activationQ29976895
The genetic and biochemical basis of FANCD2 monoubiquitinationQ33735561
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorderQ34417438
Ubiquitin in motion: structural studies of the ubiquitin-conjugating enzyme∼ubiquitin conjugateQ34666396
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.Q35176517
DNA interstrand crosslink repair and cancerQ36576047
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.Q36658074
The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiaeQ36785080
Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia.Q36889782
The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2.Q37099432
The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathwayQ37622640
The Fanconi anaemia pathway: new players and new functionsQ38825562
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repairQ39308806
Elucidating the DDK-dependent step in replication initiationQ40566942
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repairQ41914934
Modularized functions of the Fanconi anemia core complexQ41915735
Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipelineQ42634194
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.Q47074397
CTFFIND4: Fast and accurate defocus estimation from electron micrographs.Q50866431
Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.Q51006364
P433issue3
P921main subjectprotein ubiquitinationQ3547638
P304page(s)611-623
P577publication date2016-12-09
P1433published inCell ReportsQ5058165
P1476titleThe FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.
P478volume18

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cites work (P2860)
Q41369694A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents
Q89967557ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
Q92229645Allosteric mechanism for site-specific ubiquitination of FANCD2
Q89919498Association of clinical severity with FANCB variant type in Fanconi anemia
Q33762744Electron Bio-Imaging Centre (eBIC): the UK national research facility for biological electron microscopy.
Q89748657FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
Q47655228Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors.
Q90448480Fanconi anemia pathway as a prospective target for cancer intervention
Q94687068Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex
Q90296179Monoubiquitination by the human Fanconi Anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays
Q49646612Multifaceted Fanconi Anemia Signaling.
Q61449222Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility
Q89857467Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin
Q39385071Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers
Q52349345Spectrin and its interacting partners in nuclear structure and function.
Q89458938Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex
Q91013768Structure of the Fanconi anaemia monoubiquitin ligase complex
Q90462509The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair

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