scholarly article | Q13442814 |
P2093 | author name string | Michael Rowland | |
Dwight A Bellinger | |||
David R Clemmons | |||
Elizabeth P Merricks | |||
Timothy C Nichols | |||
Laura A Maile | |||
Umadevi Veluvolu | |||
Walker H Busby | |||
P2860 | cites work | Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand | Q24292425 |
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose | Q24304353 | ||
Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMR | Q24528172 | ||
Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: role of osteopontin | Q28204826 | ||
The ?5?1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro | Q29544119 | ||
Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques | Q33904134 | ||
Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels | Q34275284 | ||
Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells | Q36308611 | ||
Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection | Q36662397 | ||
Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucose | Q36807947 | ||
Screening for coronary artery disease in patients with diabetes | Q36954179 | ||
The importance of treating multiple cardiometabolic risk factors in patients with Type 2 diabetes | Q37000746 | ||
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs | Q37016720 | ||
Expression of integrins in human proliferative diabetic retinopathy membranes | Q37626359 | ||
Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor | Q37695701 | ||
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity | Q40379343 | ||
Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway | Q40627328 | ||
An allosteric Ca2+ binding site on the beta3-integrins that regulates the dissociation rate for RGD ligands | Q41168792 | ||
Stabile D-peptide analog of insulin-like growth factor-1 inhibits smooth muscle cell proliferation after carotid ballooning injury in the rat. | Q41668143 | ||
Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor | Q42442596 | ||
Effects of hypophysectomy on vascular insulin-like growth factor-I gene expression after balloon denudation in rats | Q42460924 | ||
Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: potentiation by high glucose | Q43618963 | ||
Diabetes-induced accelerated atherosclerosis in swine | Q43651836 | ||
Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury | Q43679988 | ||
Hyperglycemia-induced alteration of vascular smooth muscle phenotype | Q43901457 | ||
Regulation of vascular smooth muscle cell integrin expression by transforming growth factor β1 and by platelet‐derived growth factor‐BB | Q44143496 | ||
Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell chemotaxis. | Q44286419 | ||
Multi-year follow-up of abciximab therapy in three randomized, placebo-controlled trials of percutaneous coronary revascularization | Q44346890 | ||
Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice | Q46450897 | ||
Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli | Q46790834 | ||
Kidney involvement in a nongenetic rat model of type 2 diabetes | Q46826517 | ||
The heparin binding domain of vitronectin is the region that is required to enhance insulin-like growth factor-I signaling | Q46830967 | ||
Reduction in atherosclerotic lesion size in pigs by alphaVbeta3 inhibitors is associated with inhibition of insulin-like growth factor-I-mediated signaling | Q47253022 | ||
Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice | Q47985681 | ||
Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I. | Q51800274 | ||
Development of coronary atherosclerosis in swine with severe hypercholesterolemia. Lack of influence of von Willebrand factor or acute intimal injury. | Q52646443 | ||
Protease-resistant insulin-like growth factor (IGF)-binding protein-4 inhibits IGF-I actions and neointimal expansion in a porcine model of neointimal hyperplasia. | Q53539688 | ||
Comparison of random and oriented immobilisation of antibody fragments on mixed self-assembled monolayers. | Q53624472 | ||
Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3. | Q53655401 | ||
Abciximab Inhibits the Migration and Invasion Potential of Human Coronary Artery Smooth Muscle Cells | Q61829665 | ||
Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation | Q68512683 | ||
Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II | Q71708761 | ||
α v β 3 Integrin Expression in Normal and Atherosclerotic Artery | Q71807379 | ||
Localization of insulin-like growth factor I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis? | Q72673807 | ||
Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth | Q73500705 | ||
Beta3 integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cells | Q74376614 | ||
Selective alpha v beta 3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury: evidence for the functional importance of integrin alpha v beta 3 and osteopontin expression during n | Q74422055 | ||
Angiotensin II activation of insulin-like growth factor 1 receptor transcription is mediated by a tyrosine kinase-dependent redox-sensitive mechanism | Q78233826 | ||
Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells | Q79885437 | ||
Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet | Q80352362 | ||
P433 | issue | 18 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | antibody | Q79460 |
monoclonal antibody | Q422248 | ||
atherosclerosis | Q12252367 | ||
P304 | page(s) | 18ra11 | |
P577 | publication date | 2010-02-01 | |
P1433 | published in | Science Translational Medicine | Q1573955 |
P1476 | title | A monoclonal antibody against alphaVbeta3 integrin inhibits development of atherosclerotic lesions in diabetic pigs | |
P478 | volume | 2 |
Q74441893 | A turbulent path to plaque formation |
Q38557650 | Applying nanomedicine in maladaptive inflammation and angiogenesis |
Q34551722 | Blocking ligand occupancy of the αVβ3 integrin inhibits the development of nephropathy in diabetic pigs |
Q34441673 | Blocking αVβ3 integrin ligand occupancy inhibits the progression of albuminuria in diabetic rats. |
Q38781550 | Developing Treatments for Chronic Kidney Disease in the 21st Century |
Q27309057 | Endocytic mechanism of internalization of dietary peptide lunasin into macrophages in inflammatory condition associated with cardiovascular disease |
Q42727595 | Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation |
Q36299841 | Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle |
Q38084462 | Importance of receptor-targeted systems in the battle against atherosclerosis. |
Q36276736 | Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling |
Q39155496 | Integrin signaling in atherosclerosis. |
Q35917857 | Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis |
Q37050963 | Positron emission tomography imaging of coronary atherosclerosis |
Q36974007 | Rational design of a protein that binds integrin αvβ3 outside the ligand binding site |
Q24292863 | Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin |
Q33619657 | The arterial microenvironment: the where and why of atherosclerosis |
Q38845590 | The next generation of therapeutics for chronic kidney disease |
Q41686025 | Under-expression of α8 integrin aggravates experimental atherosclerosis |
Q41138735 | αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation |
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