A monoclonal antibody against alphaVbeta3 integrin inhibits development of atherosclerotic lesions in diabetic pigs

scientific article published on February 2010

A monoclonal antibody against alphaVbeta3 integrin inhibits development of atherosclerotic lesions in diabetic pigs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCITRANSLMED.3000476
P932PMC publication ID3938114
P698PubMed publication ID20371482

P2093author name stringMichael Rowland
Dwight A Bellinger
David R Clemmons
Elizabeth P Merricks
Timothy C Nichols
Laura A Maile
Umadevi Veluvolu
Walker H Busby
P2860cites workCrystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligandQ24292425
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucoseQ24304353
Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMRQ24528172
Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: role of osteopontinQ28204826
The ?5?1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitroQ29544119
Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaquesQ33904134
Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vesselsQ34275284
Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cellsQ36308611
Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotectionQ36662397
Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucoseQ36807947
Screening for coronary artery disease in patients with diabetesQ36954179
The importance of treating multiple cardiometabolic risk factors in patients with Type 2 diabetesQ37000746
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKsQ37016720
Expression of integrins in human proliferative diabetic retinopathy membranesQ37626359
Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factorQ37695701
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activityQ40379343
Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathwayQ40627328
An allosteric Ca2+ binding site on the beta3-integrins that regulates the dissociation rate for RGD ligandsQ41168792
Stabile D-peptide analog of insulin-like growth factor-1 inhibits smooth muscle cell proliferation after carotid ballooning injury in the rat.Q41668143
Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptorQ42442596
Effects of hypophysectomy on vascular insulin-like growth factor-I gene expression after balloon denudation in ratsQ42460924
Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: potentiation by high glucoseQ43618963
Diabetes-induced accelerated atherosclerosis in swineQ43651836
Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injuryQ43679988
Hyperglycemia-induced alteration of vascular smooth muscle phenotypeQ43901457
Regulation of vascular smooth muscle cell integrin expression by transforming growth factor β1 and by platelet‐derived growth factor‐BBQ44143496
Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell chemotaxis.Q44286419
Multi-year follow-up of abciximab therapy in three randomized, placebo-controlled trials of percutaneous coronary revascularizationQ44346890
Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver miceQ46450897
Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuliQ46790834
Kidney involvement in a nongenetic rat model of type 2 diabetesQ46826517
The heparin binding domain of vitronectin is the region that is required to enhance insulin-like growth factor-I signalingQ46830967
Reduction in atherosclerotic lesion size in pigs by alphaVbeta3 inhibitors is associated with inhibition of insulin-like growth factor-I-mediated signalingQ47253022
Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in miceQ47985681
Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I.Q51800274
Development of coronary atherosclerosis in swine with severe hypercholesterolemia. Lack of influence of von Willebrand factor or acute intimal injury.Q52646443
Protease-resistant insulin-like growth factor (IGF)-binding protein-4 inhibits IGF-I actions and neointimal expansion in a porcine model of neointimal hyperplasia.Q53539688
Comparison of random and oriented immobilisation of antibody fragments on mixed self-assembled monolayers.Q53624472
Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3.Q53655401
Abciximab Inhibits the Migration and Invasion Potential of Human Coronary Artery Smooth Muscle CellsQ61829665
Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudationQ68512683
Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-IIQ71708761
α v β 3 Integrin Expression in Normal and Atherosclerotic ArteryQ71807379
Localization of insulin-like growth factor I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis?Q72673807
Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growthQ73500705
Beta3 integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cellsQ74376614
Selective alpha v beta 3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury: evidence for the functional importance of integrin alpha v beta 3 and osteopontin expression during nQ74422055
Angiotensin II activation of insulin-like growth factor 1 receptor transcription is mediated by a tyrosine kinase-dependent redox-sensitive mechanismQ78233826
Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cellsQ79885437
Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat dietQ80352362
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
atherosclerosisQ12252367
P304page(s)18ra11
P577publication date2010-02-01
P1433published inScience Translational MedicineQ1573955
P1476titleA monoclonal antibody against alphaVbeta3 integrin inhibits development of atherosclerotic lesions in diabetic pigs
P478volume2

Reverse relations

cites work (P2860)
Q74441893A turbulent path to plaque formation
Q38557650Applying nanomedicine in maladaptive inflammation and angiogenesis
Q34551722Blocking ligand occupancy of the αVβ3 integrin inhibits the development of nephropathy in diabetic pigs
Q34441673Blocking αVβ3 integrin ligand occupancy inhibits the progression of albuminuria in diabetic rats.
Q38781550Developing Treatments for Chronic Kidney Disease in the 21st Century
Q27309057Endocytic mechanism of internalization of dietary peptide lunasin into macrophages in inflammatory condition associated with cardiovascular disease
Q42727595Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation
Q36299841Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle
Q38084462Importance of receptor-targeted systems in the battle against atherosclerosis.
Q36276736Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling
Q39155496Integrin signaling in atherosclerosis.
Q35917857Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis
Q37050963Positron emission tomography imaging of coronary atherosclerosis
Q36974007Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
Q24292863Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
Q33619657The arterial microenvironment: the where and why of atherosclerosis
Q38845590The next generation of therapeutics for chronic kidney disease
Q41686025Under-expression of α8 integrin aggravates experimental atherosclerosis
Q41138735αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation

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