Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures

scientific article published on November 1, 1991

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1991PNAS...88.9431K
P356DOI10.1073/PNAS.88.21.9431
P953full work available at URLhttps://europepmc.org/articles/PMC52731
https://europepmc.org/articles/PMC52731?pdf=render
https://pnas.org/doi/pdf/10.1073/pnas.88.21.9431
P932PMC publication ID52731
P698PubMed publication ID1658782
P5875ResearchGate publication ID21496519

P2093author name stringE. Palmer
C. W. Cotman
J. Y. Koh
P2860cites workSurvival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygenQ69693671
Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assayQ69899792
Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous systemQ70213495
Glutamate stimulates inositol phosphate formation in striatal neuronesQ28282165
A new type of glutamate receptor linked to inositol phospholipid metabolismQ28282769
Protein kinase C activity is not responsible for the expression of long-term potentiation in hippocampusQ33602890
Studies and perspectives of protein kinase C.Q34162282
Cytosolic calcium oscillatorsQ34556323
Glutamate neurotoxicity and diseases of the nervous systemQ34560997
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripesQ34633453
Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neuronsQ34695402
Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptorsQ35596173
Glutamate and the pathophysiology of hypoxic--ischemic brain damageQ38161694
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous systemQ38272501
Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementaQ40083223
Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortexQ41250860
Acetylcholine potentiates glutamate-induced neurodegeneration in cultured hippocampal neuronsQ41331909
Ionic dependence of glutamate neurotoxicityQ41343328
Two distinct quisqualate receptors regulate Ca2+ homeostasis in hippocampal neurons in vitroQ41824601
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase CQ42244464
The topography of cell loss from locus caeruleus in Alzheimer's diseaseQ42526295
Muscarinic and quisqualate receptor-induced phosphoinositide hydrolysis in primary cultures of striatal and hippocampal neurons. Evidence for differential mechanisms of activationQ43427942
Non-NMDA receptor-mediated neurotoxicity in cortical cultureQ45283851
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptorQ46046779
Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activationQ46074744
Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damageQ46135113
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonistsQ46525774
Changes in excitatory amino acid modulation of phosphoinositide metabolism during developmentQ46820333
Serotonin facilitates NMDA responses of cat neocortical neuronesQ48294264
Selective loss of central cholinergic neurons in Alzheimer's diseaseQ48342983
Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentrationQ48343318
Serotonin suppresses N-methyl-D-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat.Q48918702
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.Q50869517
Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer typeQ53196325
Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations.Q54102342
Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture.Q54356849
Glutamate neurotoxicity in cortical cell culture.Q54412952
Persistent protein kinase activity underlying long-term potentiationQ59091750
Transient increased density of NMDA binding sites in the developing rat hippocampusQ63433219
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicityQ68454340
Quisqualate neurotoxicity: a delayed, CNQX-sensitive process triggered by a CNQX-insensitive mechanism in young rat hippocampal slicesQ69371833
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectneurotoxicityQ3338704
toxic encephalopathyQ7830379
P304page(s)9431-9435
P577publication date1991-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleActivation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures
P478volume88

Reverse relations

cites work (P2860)
Q48284057(1S,3R)-ACPD, a metabotropic glutamate receptor agonist, enhances damage after global ischaemia
Q49123668A metabotropic glutamate receptor agonist regulates neurotrophin messenger RNA in rat forebrain
Q48912120Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury
Q48383223Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures
Q48794222Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat.
Q48348038Carnitine inhibits hydrolysis of inositol phospholipids induced by activation of metabotropic receptors
Q41931681Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells.
Q42483489Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX)
Q42556634Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation
Q45082499Differential modulation of carbachol and trans-ACPD-stimulated phosphoinositide turnover following traumatic brain injury
Q36229387Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors
Q42141625Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones
Q40713305Excitotoxicity, energy metabolism and neurodegeneration
Q48642245Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro
Q42450526Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway
Q48275607Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death
Q40638990Glutamate receptors and the induction of excitotoxic neuronal death
Q51381870Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Q70967223Glycine stimulation of glutamate binding to chick retinal pigment epithelium
Q33693745Group I metabotropic glutamate receptors: implications for brain diseases
Q28140990Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex
Q48439613Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: protein kinase C mediated inhibition of N-methyl-D-aspartate responses
Q73133787Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus
Q48169723L-carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity
Q42654729Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons
Q48171534Metabotropic glutamate receptor agonists protect from oxygen-glucose deprivation- and colchicine-induced apoptosis in primary cultures of cerebellar granule cells
Q41673784Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels
Q48477768Metabotropic glutamate receptors limit adenylyl cyclase-mediated effects in rat hippocampus via protein kinase C.
Q34792819Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex
Q36251450Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function
Q57744908Molecular mechanisms of glutamate-induced neurodegeneration
Q42502689NMDA-induced phosphorylation of the microtubule-associated protein MAP-2 is mediated by activation of nitric oxide synthase and MAP kinase
Q48455032Neuronal survival: cellular and molecular pathways of protection
Q73367950Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death
Q48213193Neuroprotective effect of thyrotropin-releasing hormone against excitatory amino acid-induced cell death in hippocampal slices
Q43656910Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35).
Q36850257Neuroprotective strategies to avert seizure-induced neurodegeneration in epilepsy.
Q44574612Neurotoxicity induced by amyloid beta-peptide and ibotenic acid in organotypic hippocampal cultures: protection by S-allyl-L-cysteine, a garlic compound
Q58852604Overview: Excitatory Amino Acids;Current Opinion in Therapeutic Patents June 1992
Q43744830Oxidative glutamate toxicity can be a component of the excitotoxicity cascade.
Q36330036Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum
Q48226417Protective effect of group I metabotropic glutamate receptor activation against hypoxic/hypoglycemic injury in rat hippocampal slices: timing and involvement of protein kinase C.
Q33340194Protective effects of N-methyl-D-aspartate receptor antagonism on VX-induced neuronal cell death in cultured rat cortical neurons
Q37225360Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway
Q37734247Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
Q39817839Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor.
Q32063471Regulation of the nigrostriatal pathway by metabotropic glutamate receptors during development.
Q40444534Roles of metabotropic glutamate receptors in brain plasticity and pathology
Q73105881Selective activation of group II mGluRs with LY354740 does not prevent neuronal excitotoxicity
Q40569500Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway
Q77429280The intact isolated (ex vivo) retina as a model system for the study of excitotoxicity
Q41189055The modulation of calcium currents by the activation of mGluRs. Functional implications
Q33591583The neural mechanisms underlying cholinergic cell death within the basal forebrain
Q41516234The role of apoptosis in neurodegenerative diseases.
Q37951747The role of glutamate in neuronal ischemic injury: the role of spark in fire
Q34469194Traumatic brain injury: developmental differences in glutamate receptor response and the impact on treatment

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