The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes

scientific article published on 24 September 2013

The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CYTO.2013.09.004
P932PMC publication ID3942663
P698PubMed publication ID24075100

P2093author name stringKelly A Hogan
Adam B Glick
Michael A Podolsky
Anand Ravindran
P2860cites workThe phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1Q24293229
A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelAQ24610268
Primer3 on the WWW for general users and for biologist programmersQ27861030
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysisQ28119071
Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activationQ28140522
DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunitQ28301936
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammationQ28302681
Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis modelQ28609775
Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa BQ28645847
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathwayQ30433440
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesisQ33884576
Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytesQ33947725
Analysis of tumor necrosis factor promoter responses to ultraviolet lightQ34118614
Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progressionQ34363852
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.Q34505685
Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrolQ34532343
A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexesQ34997917
Pharmacologic inhibition of ALK5 causes selective induction of terminal differentiation in mouse keratinocytes expressing oncogenic HRAS.Q35053451
Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signalingQ35103121
UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteinsQ35739622
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activationQ35752922
Expanded nuclear roles for IkappaBsQ35915945
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiationQ36497326
Ultraviolet B regulation of transcription factor families: roles of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesisQ36989955
A role for NF-kappaB-dependent gene transactivation in sunburn.Q37202396
Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancer.Q37227206
Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3.Q37315087
Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancerQ37589257
Epithelial decision makers: in search of the 'epimmunome'.Q37774241
Phosphorylation of NF-KB1-p50 is involved in NF-kappa B activation and stable DNA binding.Q38301602
Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive elementQ38318689
Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expressionQ38326909
Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β.Q38336119
A Failure of Transforming Growth Factor-β1 Negative Regulation Maintains Sustained NF-κB Activation in Gut InflammationQ38348424
IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cellsQ39631094
NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cellsQ39721374
Transforming growth factor-β stimulates the expression of eotaxin/CC chemokine ligand 11 and its promoter activity through binding site for nuclear factor-κβ in airway smooth muscle cellsQ39730421
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradationQ40174849
The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activationQ40491999
Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-beta is mediated by a nuclear factor-kappaB siteQ40566610
Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA bindingQ40639246
Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylationQ40658888
Ultraviolet irradiation blocks cellular responses to transforming growth factor-beta by down-regulating its type-II receptor and inducing Smad7.Q40810155
Inflammatory murine skin responses to UV-B light are partially dependent on endothelin-1 and mast cellsQ41090234
Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-kappaB.Q41216104
UVB and proinflammatory cytokines synergistically activate TNF-alpha production in keratinocytes through enhanced gene transcriptionQ41900868
Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophagesQ42088673
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivoQ42525065
Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-κB pathwayQ42753544
Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hostsQ42820815
Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallateQ44319791
Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph signQ45114582
Involvement of UVB-induced reactive oxygen species in TGF-beta biosynthesis and activation in keratinocytesQ45303951
Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in miceQ46882247
Specificity in stress response: epidermal keratinocytes exhibit specialized UV-responsive signal transduction pathwaysQ48148106
Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development.Q53356436
The inhibitory effects of transforming growth factor beta1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-kappaB/Rel expression.Q54080414
Molecular basis of sun-induced premature skin ageing and retinoid antagonism.Q55066366
TNF-α and IL-8 Are Upregulated in the Epidermis of Normal Human Skin after UVB Exposure: Correlation with Neutrophil Accumulation and E-Selectin ExpressionQ63859627
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinomaQ72801082
Modulation of TGF‐β1 production from human keratinocytes by UVBQ73481965
Interaction and functional cooperation of NF-kappa B with Smads. Transcriptional regulation of the junB promoterQ73939168
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-betaQ74047657
Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivatorsQ74485020
IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammationQ79288989
UVB activation of NF-kappaB in normal human keratinocytes occurs via a unique mechanismQ79668986
In vitro analysis of transforming growth factor-beta1 inhibition in novel transgenic SBE-luciferase miceQ80713314
Alteration of the TGF-beta/SMAD pathway in intrinsically and UV-induced skin agingQ81615549
Inhibition of PAX3 by TGF-beta modulates melanocyte viabilityQ82695474
The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expressionQ84454567
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectkeratinocyteQ1473931
P304page(s)652-659
P577publication date2013-09-24
P1433published inCytokineQ15745296
P1476titleThe TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes
P478volume64

Reverse relations

cites work (P2860)
Q92765039Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia
Q90471454Conditioning attenuates kidney and heart injury in rats following transient suprarenal occlusion of the abdominal aorta
Q47096948Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways.
Q35470109Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation
Q36518284High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor
Q38949050Inhibition of the cancer stem cells-like properties by arsenic trioxide, involved in the attenuation of endogenous transforming growth factor beta signal
Q36098905Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents
Q38760746JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation
Q58779206NF-κB, Mesenchymal Differentiation and Glioblastoma
Q64267176NF-κB-mediated inflammatory damage is differentially affected in SH-SY5Y and C6 cells treated with 27-hydroxycholesterol
Q53165992Photosensitivity of murine skin greatly depends on the genetic background: clinically relevant dose as a new measure to replace minimal erythema dose in mouse studies.
Q35746494Radiation quality-dependence of bystander effect in unirradiated fibroblasts is associated with TGF-β1-Smad2 pathway and miR-21 in irradiated keratinocytes
Q39005862Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways
Q92187342miR-200c Modulates the Pathogenesis of Radiation-Induced Oral Mucositis

Search more.