miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial-mesenchymal transition and the Notch signaling pathway

scientific article published on February 2017

miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial-mesenchymal transition and the Notch signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP38232
P932PMC publication ID5286431
P698PubMed publication ID28145431

P2093author name stringYan Tang
Yong Tang
Ying-Sheng Cheng
P2860cites workSNAIL transcription factor increases the motility and invasive capacity of prostate cancer cellsQ38813301
Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cellsQ39247260
IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathwayQ39462532
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizerQ40558625
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established diseaseQ40666383
The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.Q42482430
Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients.Q52639438
miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer.Q53007110
Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.Q53127210
miRNA-21 and miRNA-34a Are Potential Minimally Invasive Biomarkers for the Diagnosis of Pancreatic Ductal Adenocarcinoma.Q53388648
Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways.Q54341750
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherinQ24299768
Hypoxia-Inducible Factors and the Response to Hypoxic StressQ24629323
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transitionQ24649050
Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancerQ26738551
Notch signaling: its roles and therapeutic potential in hematological malignanciesQ26765033
Mammalian microRNAs predominantly act to decrease target mRNA levelsQ27860535
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Oncomirs - microRNAs with a role in cancerQ27860773
miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migrationQ28116054
Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P)Q28139498
Cancer statistics, 2016Q29547383
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transitionQ29617690
Upregulation of miR-23a-27a-24-2 cluster induces caspase-dependent and -independent apoptosis in human embryonic kidney cellsQ33464974
Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasionQ33630843
Snail1-dependent control of embryonic stem cell pluripotency and lineage commitmentQ33972770
Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancerQ33976883
The epigenetics of epithelial-mesenchymal plasticity in cancerQ34310378
Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissuesQ35015274
Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling.Q35987251
Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer CellsQ36010627
Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner.Q36140810
Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF.Q36297343
Notch signaling mediates hypoxia-induced tumor cell migration and invasionQ36609130
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.Q36804667
A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.Q37631219
The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissuesQ38276167
Downregulation of miR-34a contributes to the proliferation and migration of laryngeal carcinoma cells by targeting cyclin D1.Q38768826
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)38232
P577publication date2017-02-01
P1433published inScientific ReportsQ2261792
P1476titlemiR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial-mesenchymal transition and the Notch signaling pathway
P478volume7

Reverse relations

cites work (P2860)
Q92060250A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer
Q47121916Circulating microRNA-34 family low expression correlates with poor prognosis in patients with non-small cell lung cancer
Q57157498Clinical Impact of Epithelial-to-Mesenchymal Transition Regulating MicroRNAs in Pancreatic Ductal Adenocarcinoma
Q97074955Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers
Q38673790EMT: Present and future in clinical oncology
Q92702845Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis
Q57072168LGR5 promotes epithelial ovarian cancer proliferation, metastasis, and epithelial-mesenchymal transition through the Notch1 signaling pathway
Q33779304LncRNA HOTAIR acts a competing endogenous RNA to control the expression of notch3 via sponging miR-613 in pancreatic cancer
Q46367509Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy
Q90746297MiR-34a-5p Inhibits Proliferation, Migration, Invasion and Epithelial-mesenchymal Transition in Esophageal Squamous Cell Carcinoma by Targeting LEF1 and Inactivation of the Hippo-YAP1/TAZ Signaling Pathway
Q90312107MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential
Q92060901MicroRNAs Targeting MYC Expression: Trace of Hope for Pancreatic Cancer Therapy. A Systematic Review
Q58792269MicroRNA‑34b promotes proliferation, migration and invasion of Ewing's sarcoma cells by downregulating Notch1
Q96431210Mir34a constrains pancreatic carcinogenesis
Q54231141Non-Viral Based miR Delivery and Recent Developments.
Q91649956Non-coding RNAs in Pancreatic Ductal Adenocarcinoma
Q92663193Potential of Exosomal microRNA-200b as Liquid Biopsy Marker in Pancreatic Ductal Adenocarcinoma
Q46237993S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.
Q47122468Simultaneous overexpression of miR-126 and miR-34a induces a superior antitumor efficacy in pancreatic adenocarcinoma
Q92376522Snail1: A Transcriptional Factor Controlled at Multiple Levels
Q49805810Taming the Notch Transcriptional Regulator for Cancer Therapy.

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