Exosome-Based Delivery of miR-124 in a Huntington's Disease Model

scientific article published on 18 January 2017

Exosome-Based Delivery of miR-124 in a Huntington's Disease Model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.14802/JMD.16054
P932PMC publication ID5288667
P698PubMed publication ID28122430

P50authorManho KimQ55728067
Soon-Tae LeeQ79665386
Kon ChuQ86742155
Keun-Hwa JungQ86742164
Sang Kun LeeQ86742178
Wooseok ImQ88614877
Jae-Jun BanQ112059986
P2093author name stringMijung Lee
P2860cites workCirculating microRNAs as biomarkers and potential paracrine mediators of cardiovascular diseaseQ85224456
Role of exosomes/microvesicles in the nervous system and use in emerging therapiesQ21129255
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?Q21129257
Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discoveryQ24305813
Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activityQ24321699
Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review seriesQ24537164
Exosomes from human saliva as a source of microRNA biomarkersQ24614806
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.Q27340206
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genesQ28189644
The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's diseaseQ28305485
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomesQ30533859
Nonenzymatic template-directed RNA synthesis inside model protocellsQ33922191
Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's diseaseQ34009621
Altered microRNA regulation in Huntington's disease modelsQ34146968
MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanismsQ34562807
Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.Q34632614
Proteomic profiling of exosomes: current perspectivesQ34823982
Transcriptional abnormalities in Huntington diseaseQ35113363
MicroRNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum.Q35746332
Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cellsQ36512528
Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung CancerQ36832223
Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical targetQ37596483
The role of REST in transcriptional and epigenetic dysregulation in Huntington's diseaseQ37695372
Neurogenesis in Huntington's disease: can studying adult neurogenesis lead to the development of new therapeutic strategies?Q37899578
Integrins as receptor targets for neurological disordersQ37974737
Extracellular vesicles--Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseasesQ38363970
MicroRNA-124 targets CCNA2 and regulates cell cycle in STHdh(Q111)/Hdh(Q111) cells.Q38488736
Micro RNA -214,-150,-146a and-125b target Huntingtin geneQ39448940
Trans-synaptic transmission of vesicular Wnt signals through Evi/WntlessQ39753324
Slowed progression in models of Huntington disease by adipose stem cell transplantationQ39770706
Circulating microRNAs in plasma of patients with gastric cancersQ39986294
miR-124 regulates adult neurogenesis in the subventricular zone stem cell nicheQ42243673
Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment.Q42488000
A microRNA-based gene dysregulation pathway in Huntington's diseaseQ45307225
Exosomes are released by cultured cortical neurones.Q46918951
Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptorQ48440531
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectHuntington's diseaseQ190564
P304page(s)45-52
P577publication date2017-01-18
P1433published inJournal of movement disordersQ26842217
P1476titleExosome-Based Delivery of miR-124 in a Huntington's Disease Model
P478volume10

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cites work (P2860)
Q92051086Advances in therapeutic applications of extracellular vesicles
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Q47986173Exosomal miR-7 Mediates Bystander Autophagy in Lung after Focal Brain Irradiation in Mice
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Q89909722Exosome-based small RNA delivery: Progress and prospects
Q92665254Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a
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Q98159114Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy
Q89494159MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
Q45304134Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes
Q89910191Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances
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