RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk

scientific article published on February 2014

RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JBMR.2043
P932PMC publication ID3946983
P698PubMed publication ID23873632

P50authorDouglas P. KielQ46935730
Nathalie FranchimontQ47015108
Angela M. CheungQ48657503
Elizabeth J SamelsonQ57306616
P2093author name stringClaus Christiansen
Andrea Wang
Paul D Miller
Ogo Egbuna
Mary S Anthony
Nadia S Daizadeh
Nathalie Franchimont
Luanda Grazette
Suresh R Siddhanti
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Denosumab for prevention of fractures in postmenopausal women with osteoporosisQ28254528
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalizationQ28283679
Coronary calcification in patients with chronic kidney disease and coronary artery diseaseQ33560509
Comparison of estimated creatinine clearance among five formulae (Cockroft-Gault, Jelliffe, Sanaka, simplified 4-variable MDRD and DAF) and the 24hours-urine-collection creatinine clearanceQ33951218
RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular functionQ34123475
A radiographic study on the associations of age and prevalence of vertebral fractures with abdominal aortic calcification in Japanese postmenopausal women and menQ34211384
Evaluating the performance of equations for estimating glomerular filtration rate.Q35564754
Osteoprotegerin/RANKL axis and progression of coronary artery calcification in hemodialysis patientsQ35995048
Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strengthQ36269835
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisQ36368706
Vascular calcifications: pathogenesis, management, and impact on clinical outcomes.Q36665930
Vascular calcification and osteoporosis--from clinical observation towards molecular understandingQ36676122
The osteoprotegerin/RANK/RANKL system: a bone key to vascular diseaseQ36686037
Chronic kidney disease: effects on the cardiovascular systemQ36868237
Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.Q37188485
Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in miceQ37278407
Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium StudyQ37306185
Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rateQ37334515
Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip.Q40324778
Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortalityQ43546639
Design and methods of the Raloxifene Use for The Heart (RUTH) studyQ43730182
Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D.Q43764592
Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular diseaseQ43865169
Increased plasma concentrations of osteoprotegerin in type 2 diabetic patients with microvascular complicationsQ44490286
Effective doses of ibandronate do not influence the 3-year progression of aortic calcification in elderly osteoporotic womenQ44936850
Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function.Q45230608
Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly womenQ46130374
RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized ratsQ46212098
Year-by-year analysis of cardiovascular events in the Multiple Outcomes of Raloxifene Evaluation (MORE) trialQ46479671
Aortic calcification and the risk of osteoporosis and fracturesQ46548686
Volumetric BMD and Vascular Calcification in Middle-Aged Women: The Study of Women's Health Across the NationQ57392301
Effects of denosumab on fracture and bone mineral density by level of kidney functionQ58970644
Low serum levels of soluble RANK ligand are associated with the presence of coronary artery disease in menQ73167301
New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up studyQ73556145
Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal studyQ74152546
Serum osteoprotegerin levels are associated with the presence and severity of coronary artery diseaseQ74711101
Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart StudyQ77084584
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- miceQ79903873
Progression of vascular calcifications is associated with greater bone loss and increased bone fracturesQ80461984
Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular diseaseQ80589399
French women, fractures and aortic calcificationsQ81162339
Calcifications in the abdominal aorta predict fractures in men: MINOS studyQ81345932
Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarctionQ81801138
P433issue2
P921main subjectaortaQ101004
osteoporosisQ165328
circulatory systemQ11068
P304page(s)450-457
P577publication date2014-02-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleRANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk
P478volume29

Reverse relations

cites work (P2860)
Q51776576Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women.
Q44657342Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
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Q58715301Circulating osteogenic proteins are associated with coronary artery calcification and increase after myocardial infarction
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Q39296189Comparative Safety and Effectiveness of Denosumab Versus Zoledronic Acid in Patients With Osteoporosis: A Cohort Study
Q40765493Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.
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Q38220743Denosumab: a review of its use in postmenopausal women with osteoporosis
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Q37292841Lower leg arterial calcification assessed by high-resolution peripheral quantitative computed tomography is associated with bone microstructure abnormalities in women
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