Leveraging melanocortin pathways to treat glomerular diseases

scientific article published on March 2014

Leveraging melanocortin pathways to treat glomerular diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1053/J.ACKD.2013.09.004
P8608Fatcat IDrelease_sdkji2eqqzglzmhbp2licgay6u
P932PMC publication ID3950821
P698PubMed publication ID24602463

P2093author name stringRujun Gong
P2860cites workIn vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH)Q74319170
Glucocorticoid effects on boneQ74645772
Discovery and development of novel melanogenic drugs. Melanotan-I and -IIQ77370427
IkappaB-NF-kappaB structures: at the interface of inflammation controlQ77726306
Long-term Outcome of Adult Onset Idiopathic Minimal Change DiseaseQ80524322
alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstructionQ81272591
Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms)Q84851934
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humansQ24323379
ACTH protects against glucocorticoid-induced osteonecrosis of boneQ24631407
Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gelQ24632899
H.p. Acthar gel and cosyntropin review: clinical and financial implicationsQ24645310
The melanocortin systemQ28205910
Melanocortins and their Receptors and AntagonistsQ28208352
Distribution of cDNA for melanocortin receptor subtypes in human tissuesQ28297582
Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man.Q30453648
Structure-function of the G protein-coupled receptor superfamilyQ30576993
The role of corticosteriods in the regulation of vascular toneQ33634237
Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with juvenile dermatomyositisQ33779452
Glucocorticoid-remediable aldosteronism.Q33795609
The role of the transcription factor CREB in immune functionQ33920635
The proopiomelanocortin systemQ33921597
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A.Q33943247
Melanocortin 1 receptor agonists reduce proteinuriaQ34117792
Melanocortin receptors: their functions and regulation by physiological agonists and antagonistsQ34226802
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaquesQ34304856
A review and update on melanocyte stimulating hormone therapy: afamelanotideQ34359726
Bremelanotide: an overview of preclinical CNS effects on female sexual functionQ34584136
Evaluation of the safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study.Q34586801
Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?Q34708310
Management of nephrosis; the use of long continued hormone therapyQ34930608
Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.Q34943036
Podocyte biology and response to injuryQ35005456
The melanocortin agonist AP214 exerts anti-inflammatory and proresolving propertiesQ35069961
Chronic glucocorticoid therapy amplifies glomerular injury in rats with renal ablationQ35579156
Targeting melanocortin receptors as a novel strategy to control inflammation.Q35682900
Crucial role of the melanocortin receptor MC1R in experimental colitisQ35760868
Glucocorticoid-mediated mineralocorticoid receptor activation and hypertensionQ35806295
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Q36003378
Glomerular disease workshop.Q36305204
MAPK signal specificity: the right place at the right timeQ36444123
The renaissance of corticotropin therapy in proteinuric nephropathiesQ36520242
Studies on the physiological functions of the melanocortin systemQ36640631
Cardiovascular and renal actions of melanocyte-stimulating hormone peptidesQ36672425
AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortalityQ36681505
Regulation of immune tolerance by anti-inflammatory neuropeptidesQ36691091
Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanismsQ36728787
Inhibition of Rho is required for cAMP-induced melanoma cell differentiation.Q36873446
Anti-inflammatory neuropeptides: a new class of endogenous immunoregulatory agentsQ37206399
Inducible rodent models of acquired podocyte diseases.Q37265903
Regulation of the hypothalamic-pituitary-adrenal axisQ37538330
Melanocortin 1 receptor and risk of cutaneous melanoma: a meta-analysis and estimates of population burdenQ37815455
ACTH: a short introductory reviewQ37824466
Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH).Q37923991
Childhood nephrotic syndrome--current and future therapiesQ38017937
Immunotherapy in renal diseasesQ38019101
Evidence that the insulin secretagogue, β-cell-tropin, is ACTH22–39Q38354936
The Medical Research Council trial of short-term high-dose alternate day prednisolone in idiopathic membranous nephropathy with nephrotic syndrome in adults. The MRC Glomerulonephritis Working PartyQ38929940
Characterization of the sea bass melanocortin 5 receptor: a putative role in hepatic lipid metabolismQ39774322
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse isletsQ39777522
Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism.Q39853875
Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cellsQ40024086
Adrenocorticotrophin and corticosteroid changes during dexamethasone infusion to intact and synacthen infusion to hypophysectomized foetusesQ40121182
Corticotropin in human plasma general considerationsQ40141956
Melanocortin-3 receptor activates MAP kinase via PI3 kinaseQ40190529
Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene statusQ40370257
ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans.Q40601743
Improving pharmacokinetic properties of adrenocorticotropin by site-specific lipid modificationQ40638858
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentationQ41028982
Diagnosis and management of glomerular diseasesQ41484969
Pathogenesis of lipoid nephrosis: a disorder of T-cell functionQ41509804
Evidence that glycosylation of pro-opiocortin and ACTH influences their proteolysis by trypsin and blood proteasesQ41549530
New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.Q41626209
A.C.T.H. in nephrosisQ41706165
Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma modelQ42459634
Treatment of resistant glomerular diseases with adrenocorticotropic hormone gel: a prospective trialQ42654718
Focal segmental glomerulosclerosis in a patient with isolated ACTH deficiency and reversible hypothyroidismQ43265903
Insulin release after ACTH, glucagon and adenosine-3'-5'-phosphate (cyclic AMP) in the perfused isolated rat pancreasQ44313382
Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeuticsQ44687204
Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing's syndromeQ44807843
Activation of MAP kinase by MC4-R through PI3 kinaseQ44921489
ACTH therapy in nephrotic syndrome induced by idiopathic membranous nephropathy.Q45167590
The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicityQ45197915
Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidneyQ45224292
Modulation of blood pressure by central melanocortinergic pathwaysQ46192750
A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathyQ46907543
ACTH-induced improvement in the nephrotic syndrome in patients with a variety of diagnosesQ47717220
alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammationQ48189680
A randomized controlled trial of prednisone in patients with idiopathic membranous nephropathy.Q50557738
Change of melanocortin receptor expression in rat kidney ischemia-reperfusion injury.Q53529916
Effect of administration of ACTH on insulin secretion in dogs.Q53755530
Beneficial effects of ACTH on the serum lipoprotein profile and glomerular function in patients with membranous nephropathy.Q54077444
Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3 and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leucocytes.Q54674363
Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clonesQ59070352
Tall stature in familial glucocorticoid deficiencyQ62750321
A glomerular permeability factor produced by human T cell hybridomasQ67851043
Hypersensitivity to different ACTH peptidesQ68664753
Evidence suggesting under-treatment in adults with idiopathic focal segmental glomerulosclerosis. Regional Glomerulonephritis Registry StudyQ69009531
Increased experimental metastatic capacity of a murine melanoma following induction of differentiationQ69508707
Hypothalamic control of lipid metabolismQ70084475
Evaluation and management of corticotropin allergyQ70179702
Levamisole as immunostimulant in the clinical practiceQ70810759
Primary nephrotic syndrome in children: clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. A Report of the International Study of Kidney Disease in ChildrenQ71087118
Stimulation of insulin secretion from mouse pancreatic islets, maintained in tissue culture, by the pituitary neurointermediate lobe of the genetically obese mouse (obob)Q72864445
Thrombotic microangiopathic haemolytic anaemia (thrombotic microangiopathy)Q73953443
P433issue2
P304page(s)134-151
P577publication date2014-03-01
P1433published inAdvances in Chronic Kidney DiseaseQ15763121
P1476titleLeveraging melanocortin pathways to treat glomerular diseases
P478volume21

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cites work (P2860)
Q38667777Acquired Resistance to Corticotropin Therapy in Nephrotic Syndrome: Role of De Novo Neutralizing Antibody
Q35976834Acthar gel in the treatment of nephrotic syndrome: a multicenter retrospective case series
Q92531741Adrenocorticotropic Hormone in the Treatment of Focal Segmental Glomerulosclerosis Following Kidney Transplantation
Q37070458Adrenocorticotropic hormone analog use for podocytopathies
Q37651364Adrenocorticotropic hormone therapy for the treatment of idiopathic nephrotic syndrome in children and young adults: a systematic review of early clinical studies with contemporary relevance
Q38703169Clinical and Economic Evaluation of Repository Corticotropin Injection: A Narrative Literature Review of Treatment Efficacy and Healthcare Resource Utilization for Seven Key Indications
Q53818437Complete Remission of Post-transplantation Recurrence of Focal Segmental Glomerulosclerosis With the Use of Adrenocorticotrophic Hormone Gel: Case Report.
Q38610760Developments and new vistas in the field of melanocortins.
Q38858772Efficacy and safety of adrenocorticotropic hormone treatment in glomerular diseases: a systematic review and meta-analysis
Q47212986GPCRs as targets for approved drugs: How many targets and how many drugs?
Q41467613Low-dose synthetic adrenocorticotropic hormone-analog therapy for nephrotic patients: results from a single-center pilot study.
Q57813728Management of steroid-resistant nephrotic syndrome in children and adolescents
Q46594445Melanocortin 1 receptor agonist protects podocytes through catalase and RhoA activation.
Q26865343Melanocortin peptides: potential targets in systemic lupus erythematosus
Q41688065Multiple Targets for Novel Therapy of FSGS Associated with Circulating Permeability Factor
Q64230728New strategies and perspectives on managing IgA nephropathy
Q90430043Relapse of Nephrotic Syndrome after Adrenocorticotropic Hormone-Induced Remission: Implications of Adrenocorticotropic Hormone Antibodies
Q35219562Repository corticotropin injection in a patient presenting with focal segmental glomerulosclerosis, rheumatoid arthritis, and optic neuritis: a case report
Q26746146Sex-specific effects of LiCl treatment on preservation of renal function and extended life-span in murine models of SLE: perspective on insights into the potential basis for survivorship in NZB/W female mice
Q90685929Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives
Q37139449The podocyte as a direct target for treatment of glomerular disease?
Q98178834Use of Repository Corticotropin Gel (Acthar) in Progressive Nephrotic Syndrome Secondary to Transplant Glomerulopathy: A Report of Three Cases

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