Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection against Shigellosis in a Controlled Human Challenge Study

scientific article published on 07 December 2016

Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection against Shigellosis in a Controlled Human Challenge Study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/CVI.00412-16
P932PMC publication ID5299116
P698PubMed publication ID27927680

P50authorMarcela F. PasettiQ56380831
Karen L KotloffQ63214788
P2093author name stringWilliam C Blackwelder
Amanda D Buskirk
Shannon J Heine
Rezwanul Wahid
Avital A Shimanovich
P2860cites workGlobal burden of Shigella infections: implications for vaccine development and implementation of control strategiesQ33749510
Updated postlicensure surveillance of the meningococcal C conjugate vaccine in England and Wales: effectiveness, validation of serological correlates of protection, and modeling predictions of the duration of herd immunityQ33825722
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasionQ34192675
Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control studyQ34345075
Standardization of an opsonophagocytic assay for the measurement of functional antibody activity against Streptococcus pneumoniae using differentiated HL-60 cellsQ35229917
Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidisQ35272921
Hypothesis for vaccine development: protective immunity to enteric diseases caused by nontyphoidal salmonellae and shigellae may be conferred by serum IgG antibodies to the O-specific polysaccharide of their lipopolysaccharidesQ35335585
Broadly protective Shigella vaccine based on type III secretion apparatus proteinsQ35805439
Aetiology-Specific Estimates of the Global and Regional Incidence and Mortality of Diarrhoeal Diseases Commonly Transmitted through FoodQ35859832
Human immunity to the meningococcus. I. The role of humoral antibodiesQ36269707
Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a.Q36920244
Immune response against lipopolysaccharide and invasion plasmid-coded antigens of shigellae in Vietnamese and Swedish dysenteric patients.Q37064863
Progress and pitfalls in Shigella vaccine researchQ37105553
Monoclonal Antibodies to Shigella Lipopolysaccharide Are Useful for Vaccine Production.Q37163698
Immunoglobulin M, A, and G antibody response to lipopolysaccharide O antigen in symptomatic and asymptomatic Shigella infectionsQ37167794
Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United StatesQ37252348
Characterization of a novel fusion protein from IpaB and IpaD of Shigella spp. and its potential as a pan-Shigella vaccine.Q37335984
Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study.Q37477196
Correlation between serum bactericidal activity against Neisseria meningitidis serogroups A, C, W-135 and Y measured using human versus rabbit serum as the complement sourceQ37531323
Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypesQ37720658
Correlates of protection induced by vaccinationQ37750121
Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208.Q39146446
Differential host immune responses to epidemic and endemic strains of Shigella dysenteriae type I.Q39408427
Adaptive immune response to Shigella flexneri 2a cydC in immunocompetent mice and mice lacking immunoglobulin A.Q39510614
Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2aQ39511268
Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and Shigella sonnei proteosome-lipopolysaccharide vaccines in animal models.Q40267400
Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculumQ40538332
Characteristics of Shigella sonnei infection of volunteers: signs, symptoms, immune responses, changes in selected cytokines and acute-phase substances.Q40683413
Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2Q40687041
Laboratory correlates of protection against Haemophilus influenzae type b disease. Importance of assessment of antibody avidity and immunologic memoryQ46136264
Phagocytic and bactericidal properties of macrophages of mice immunized with outer membrane proteins (OMP) of ShigellaQ50198940
Role of bacterial and host factors in the pathogenesis of Shigella septicemia.Q54324435
Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosisQ57937885
Delayed and reduced adaptive humoral immune responses in children with shigellosis compared with in adultsQ57939911
Pneumococcal conjugate vaccination: correlates of protectionQ63392515
Antibody-dependent cell-mediated antibacterial activity: K lymphocytes, monocytes, and granulocytes are effective against shigellaQ67235888
Natural immunity to shigellosis in two groups with different previous risks of exposure to Shigella is only partly expressed by serum antibodies to lipopolysaccharideQ68080096
Serum antibodies to lipopolysaccharide and natural immunity to shigellosis in an Israeli military populationQ68134308
Serum antibody responses against shigella lipopolysaccharides and invasion plasmid-coded antigens in shigella infected Swedish patientsQ72715742
Characterization and quantitative analysis of serum IgG class and subclass response to Shigella sonnei and Shigella flexneri 2a lipopolysaccharide following natural Shigella infectionQ73292613
Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free mediaQ81445405
P433issue2
P921main subjectantibodyQ79460
shigellosisQ327298
P577publication date2016-12-07
P1433published inClinical and Vaccine ImmunologyQ5133811
P1476titleFunctional and Antigen-Specific Serum Antibody Levels as Correlates of Protection against Shigellosis in a Controlled Human Challenge Study
P478volume24

Reverse relations

cites work (P2860)
Q91760327A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity against Yersinia Infection in Adult and Infant Mice
Q57929967A Novel Proteome Microarray Discriminates Targets of Human Antibody Reactivity following Oral Vaccination and Experimental Challenge
Q92801042Characterization and immunogenicity of a Shigella flexneri 2a O-antigen bioconjugate vaccine candidate
Q90300290Complement in malaria immunity and vaccines
Q91801457Consensus Report on Shigella Controlled Human Infection Model: Conduct of Studies
Q47103928Development and Qualification of an Opsonophagocytic Killing Assay To Assess Immunogenicity of a Bioconjugated Escherichia coli Vaccine
Q55333715Development, Interlaboratory Evaluations, and Application of a Simple, High-Throughput Shigella Serum Bactericidal Assay.
Q56378326Experimental infection of human volunteers
Q40192692Human immune responses against Shigella and enterotoxigenic E. coli: Current advances and the path forward
Q99616552Immune Response Characterization after Controlled Infection with Lyophilized Shigella sonnei 53G
Q47578477In silico design of a novel chimeric shigella IpaB fused to C terminal of clostridium perfringens enterotoxin as a vaccine candidate.
Q57927103Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990-2016
Q91705205Oral immunization with LacVax® OmpA induces protective immune response against Shigella flexneri 2a ATCC 12022 in a murine model
Q102056730Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study
Q47701060Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model
Q91881906Serum IgG antibodies to Shigella lipopolysaccharide antigens - a correlate of protection against shigellosis
Q56383780Shigellosis
Q91449694Updates on immunologic correlates of vaccine-induced protection

Search more.