Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity

scientific article published on March 2014

Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.12523
P932PMC publication ID3954487
P698PubMed publication ID24730061

P2093author name stringI-Hsin Lin
Tz-Chong Chou
Fu-Chi Chen
Ching-Yu Shih
James-Cheng Ding
P2860cites workEffect of nifedipine monotherapy on platelet aggregation in patients with untreated essential hypertensionQ70244861
Peroxisome proliferator-activated receptor-gamma ligands inhibit nitric oxide synthesis in vascular smooth muscle cellsQ73901266
Platelet activation increases with the severity of peripheral arterial disease: implications for clinical managementQ81160258
Inhibitory effect of α-lipoic acid on platelet aggregation is mediated by PPARsQ83579757
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formationQ24304178
Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase DQ28245266
PKCalpha regulates platelet granule secretion and thrombus formation in miceQ28505136
Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activationQ28512827
Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathwayQ28579360
NF-kappaB: a key role in inflammatory diseasesQ29617726
The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptorsQ30486738
Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end productsQ33595290
Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart studyQ34023032
PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growthQ34311560
InsP3R-associated cGMP Kinase Substrate Determines Inositol 1,4,5-Trisphosphate Receptor Susceptibility to Phosphoregulation by Cyclic Nucleotide-dependent KinasesQ34333875
New regulators of NF-kappaB in inflammationQ34858737
A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activationQ35672398
Mechanisms of Platelet Activation and Integrin αIIβ3.Q36015900
Pleiotropic effects of nifedipine on atherosclerosisQ36447385
Enhanced nitric oxide and cyclic GMP formation plays a role in the anti-platelet activity of simvastatinQ36510042
PPARs and molecular mechanisms of transrepressionQ36791361
Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levelsQ37788999
NF-kappaB inhibitors impair platelet activation responsesQ38352662
Emerging role of PPAR-β/δ in inflammatory process associated to experimental periodontitisQ38910012
Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophagesQ39451400
Integrin signaling: the platelet paradigmQ41733864
Nifedipine activates PPARgamma and exerts antioxidative action through Cu/ZnSOD independent of blood-pressure lowering in SHRSP.Q42165264
Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient miceQ43052161
Effects of nifedipine on platelet functionQ45758962
Antiplatelet actions of statins and fibrates are mediated by PPARsQ46158854
The antiplatelet activity of magnolol is mediated by PPAR-β/γ.Q54500540
β2-Integrins and Acquired Glycoprotein IIb/IIIa (GPIIb/IIIa) Receptors Cooperate in NF-κB Activation of Human NeutrophilsQ56982032
Lack of evidence for voltage dependent calcium channels on plateletsQ69381627
The effects of nifedipine on platelet aggregation and plasma 6-keto-PGF1 alpha, and its interaction with indomethacinQ69928393
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectnifedipineQ39111
NF-κBQ411114
P304page(s)1490-1500
P577publication date2014-03-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAntiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity
P478volume171

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cites work (P2860)
Q39200522Antiplatelet activity of drugs used in hypertension, dyslipidemia and diabetes: Additional benefit in cardiovascular diseases prevention.
Q38384163Antiplatelet treatment in essential hypertension: where do we stand?
Q35602333Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets
Q42592882New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker
Q91841855Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study
Q92959413Role of NF-κB in Platelet Function

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