FAK signalling controls insulin sensitivity through regulation of adipocyte survival.

scientific article published on 06 February 2017

FAK signalling controls insulin sensitivity through regulation of adipocyte survival. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2017NatCo...814360L
P356DOI10.1038/NCOMMS14360
P932PMC publication ID5303880
P698PubMed publication ID28165007

P50authorMinna WooQ71170467
Daniel WinerQ79290461
Sally Yu ShiQ83877145
P2093author name stringErica P Cai
Cynthia T Luk
Stephanie A Schroer
Mansa Krishnamurthy
Jara J Brunt
Tharini Sivasubramaniyam
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Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumorsQ72347547
Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivoQ77996269
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes modelsQ80465675
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Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageingQ38450658
In vivo knockdown of adipocyte erythropoietin receptor does not alter glucose or energy homeostasisQ38453369
Changes in integrin expression during adipocyte differentiationQ40375216
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cellsQ40561080
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivoQ41491877
Regulation of obesity-related insulin resistance with gut anti-inflammatory agentsQ42174194
Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.Q42457673
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolismQ42813608
Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway.Q42819682
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesisQ44564224
Role of p38, ERK1/2, focal adhesion kinase, RhoA/ROCK and cytoskeleton in the adipogenesis of human mesenchymal stem cellsQ47944614
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53Q24300771
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationQ24307387
FAK in cancer: mechanistic findings and clinical applicationsQ27026533
Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samplesQ28216057
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesQ28506930
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophiesQ28511784
Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiationQ28573850
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2Q28646392
Focal adhesion kinase: in command and control of cell motilityQ29615192
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humansQ29622900
Control of adhesion-dependent cell survival by focal adhesion kinaseQ30442196
Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosisQ33661588
Muscle-specific Pten deletion protects against insulin resistance and diabetesQ33714209
Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat dietQ34075443
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intoleranceQ34137882
Erythropoietin protects against diabetes through direct effects on pancreatic beta cellsQ34420833
α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissuesQ34519963
A pericellular collagenase directs the 3-dimensional development of white adipose tissueQ34522343
Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient miceQ34696866
Transcriptional control of adipose lipid handling by IRF4Q34713714
Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.Q34718758
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscleQ34790967
Adipose tissue remodeling and obesityQ35015740
High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammationQ35123520
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophyQ35210714
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityQ35964742
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule traffickingQ36047564
The role of focal-adhesion kinase in cancer - a new therapeutic opportunityQ36216076
The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetesQ36452423
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesityQ36673494
Insulin signalling mechanisms for triacylglycerol storageQ36838847
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.Q37110569
Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-IQ37125989
Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.Q37157315
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
preproinsulinQ7240673
P304page(s)14360
P577publication date2017-02-06
P1433published inNature CommunicationsQ573880
P1476titleFAK signalling controls insulin sensitivity through regulation of adipocyte survival
P478volume8

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cites work (P2860)
Q90027782Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans
Q48265976Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system.
Q90461405Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases
Q47664837FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.
Q57112936Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages
Q94544705Ginsenoside Rg3 Alleviates ox-LDL Induced Endothelial Dysfunction and Prevents Atherosclerosis in ApoE-/- Mice by Regulating PPARγ/FAK Signaling Pathway
Q64071910Glucose Drives Growth Factor-Independent Esophageal Cancer Proliferation via Phosphohistidine-Focal Adhesion Kinase Signaling
Q42367244Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistance
Q54980633Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity.
Q101051147YAP and TAZ protect against white adipocyte cell death during obesity

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