A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population.

scientific article published on 18 March 2014

A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FONC.2014.00053
P932PMC publication ID3957277
P698PubMed publication ID24672774
P5875ResearchGate publication ID261141048

P50authorEuridice CarmonaQ67521456
P2093author name stringBarbara C Vanderhyden
Manijeh Daneshmand
Kenneth Garson
Olga Collins
Lisa F Gamwell
Ensaf M Al-Hujaily
Elizabeth A Macdonald
Lauren E Carter
Curtis W McCloskey
Reuben L Goldberg
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancerQ24323885
Cancer stem cells, epithelial-mesenchymal transition, and drug resistance in high-grade ovarian serous carcinomaQ26998068
Integrated genomic analyses of ovarian carcinomaQ27860518
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.Q29417084
Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cellsQ39564832
Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancerQ39668407
Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cellsQ39748143
Reprogramming of the transcriptome in a novel chromosome 3 transfer tumor suppressor ovarian cancer cell line model affected molecular networks that are characteristic of ovarian cancer.Q39898694
Epithelial-stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancerQ40045294
Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancerQ40164561
Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: functional similarity to the human disease and identification of prospective tumoral markers and targets.Q40358652
Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancerQ40488126
Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers.Q40506716
Development of a syngeneic mouse model for events related to ovarian cancerQ40888613
Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexityQ41033264
Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat.Q41171492
Pre-invasive ovarian mucinous tumors are characterized by CDKN2A and RAS pathway aberrationsQ47266001
The stem-cell profile of ovarian surface epithelium is reproduced in the oviductal fimbriae, with increased stem-cell marker density in distal parts of the fimbriaeQ47907453
The mouse ovarian surface epithelium contains a population of LY6A (SCA-1) expressing progenitor cells that are regulated by ovulation-associated factorsQ48641462
Changes in gene expression during progression of ovarian carcinomaQ49222374
Microarray proteomic analysis discriminates tumorigenic mouse ovarian surface epithelial cells of divergent aggressive potentialQ51649163
A new mechanism of release from senescence: suppression of p16INK4a by beta-catenin.Q53323063
Serous carcinogenesis in the fallopian tube: a descriptive classification.Q53325750
Silencing of the UCHL1 gene in human colorectal and ovarian cancers.Q53346854
Serum Autotaxin is not a Useful Biomarker for Ovarian CancerQ59939722
CpG Island Methylation of DNA Damage Response Genes in Advanced Ovarian CancerQ61608137
Species- and cell type-specific requirements for cellular transformationQ80482709
Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic typesQ83855414
Epiregulin as a marker for the initial steps of ovarian cancer developmentQ84571422
A candidate precursor to serous carcinoma that originates in the distal fallopian tube.Q33264156
Cancer stem cells: a stride towards cancer cure?Q34086837
Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumoursQ34097804
Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancerQ34126314
LRRC3B gene is frequently epigenetically inactivated in several epithelial malignancies and inhibits cell growth and replication.Q34253325
Ovarian surface epithelium at the junction area contains a cancer-prone stem cell nicheQ34331396
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer.Q34519901
Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer modelQ34769954
Distinct requirements for Ras oncogenesis in human versus mouse cellsQ34787097
Ankyrin repeat domain 1, ANKRD1, a novel determinant of cisplatin sensitivity expressed in ovarian cancerQ34871343
A mouse model for the molecular characterization of brca1-associated ovarian carcinomaQ35646878
Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillinQ35914413
Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cellsQ36164111
Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival.Q36201267
Cyclin D1 predicts the prognosis of advanced serous ovarian cancerQ36230481
Methylation of tumor suppressor genes in ovarian cancerQ36386613
Induction of ovarian cancer by defined multiple genetic changes in a mouse model systemQ36496578
Technical challenges and limitations of current mouse models of ovarian cancerQ36510070
Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancerQ36663567
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancerQ36956156
Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cellsQ37065361
Histologic subtypes of ovarian carcinoma: an overview.Q37101055
Modeling High-Grade Serous Carcinoma: How Converging Insights into Pathogenesis and Genetics are Driving Better Experimental PlatformsQ37119791
Sporadic epithelial ovarian cancer: clinical relevance of BRCA1 inhibition in the DNA damage and repair pathwayQ37203864
Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate modelQ37365555
Histopathology of ovarian tumors in laying hens: a preclinical model of human ovarian cancer.Q37381736
Epithelial ovarian cancer experimental models.Q37708938
Ovarian cancer stem cells: working towards the root of stemnessQ38058671
Cancer stem cells niche: a target for novel cancer therapeuticsQ38065528
Revisiting ovarian cancer preclinical models: implications for a better management of the diseaseQ38083980
Ovarian surface epithelium as a source of ovarian cancers: unwarranted speculation or evidence-based hypothesis?Q38096167
Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesisQ38287695
Thrombomodulin mediates the progression of epithelial ovarian cancer cellsQ39114905
Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivoQ39136622
P4510describes a project that usesImageJQ1659584
M0505Q54903413
STOSEQ54970603
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
cell lineQ21014462
P304page(s)53
P577publication date2014-03-18
P1433published inFrontiers in OncologyQ26839986
P1476titleA new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population
P478volume4

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described by source (P1343)
Q54903413M0505
Q54970603STOSE

cites work (P2860)
Q4716044717β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression
Q95933360Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
Q37686049BRCA1 expression, proliferative and apoptotic activities in ovarian epithelial inclusions
Q91004442BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway
Q90193380Characteristics of in Vivo Model Systems for Ovarian Cancer Studies
Q57699553Discrimination of normal and malignant mouse ovarian surface epithelial cells in vitro using Raman microspectroscopy
Q36097633Editorial: Advances in Epithelial Ovarian Cancer: Model Systems, Microenvironmental Influences, Therapy, and Origins
Q26783909Emerging and Evolving Ovarian Cancer Animal Models
Q48600293Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models.
Q89423005GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer
Q36413849Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression
Q30355682IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in mice.
Q37362760Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium
Q61810852Non-Invasive Fluorescent Monitoring of Ovarian Cancer in an Immunocompetent Mouse Model
Q96431876Non-canonical WNT5a regulates Epithelial-to-Mesenchymal Transition in the mouse ovarian surface epithelium
Q64911672Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics.
Q47160060PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state
Q61443800Prognostic values of GMPS, PR, CD40, and p21 in ovarian cancer
Q89454393Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model
Q91810300Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton
Q35859678Spontaneous Transformation of Murine Oviductal Epithelial Cells: A Model System to Investigate the Onset of Fallopian-Derived Tumors
Q58795166UnPAXing the Divergent Roles of PAX2 and PAX8 in High-Grade Serous Ovarian Cancer
Q91297679WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer
Q50560992β-catenin downregulates Dicer to promote ovarian cancer metastasis.

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