Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers

scientific article published on 18 December 2013

Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.03130-13
P932PMC publication ID3958053
P698PubMed publication ID24352471

P50authorMargaret E. AckermanQ57012155
Galit AlterQ88683228
Chris Bailey-KelloggQ89469549
P2093author name stringAnna F Licht
Anne-Sophie Dugast
Ickwon Choi
Todd Suscovich
Jennifer I Lai
P2860cites workADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challengeQ27342615
High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samplesQ28389941
The major genetic determinants of HIV-1 control affect HLA class I peptide presentationQ29417018
A whole-genome association study of major determinants for host control of HIV-1Q29614891
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samplesQ30498394
IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccinesQ33827771
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.Q34009945
Additive contribution of HLA class I alleles in the immune control of HIV-1 infectionQ34120809
Antibody-dependent cell-mediated viral inhibition emerges after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys coincident with gp140-binding antibodies and is effective against neutralization-resistant virusesQ34982646
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infectionQ34994754
High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllersQ35005192
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene familyQ36363231
Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activityQ36797342
Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaquesQ37033311
Immunogenetics of spontaneous control of HIVQ37051202
Emerging concepts on the role of innate immunity in the prevention and control of HIV infectionQ37955261
A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV.Q38631835
IgG subclass responses to human immunodeficiency virus-1 antigens: lack of IgG2 response to gp41 correlates with clinical manifestation of diseaseQ39157800
Determining the phagocytic activity of clinical antibody samplesQ39432766
Divergent immunoglobulin g subclass activity through selective Fc receptor bindingQ40344836
Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2bQ40529181
Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllersQ40659603
Antibody-dependent cellular cytotoxicity independently predicts survival in severely immunocompromised human immunodeficiency virus-infected patientsQ41689302
HIV type 1-specific IgG2 antibodies: markers of helper T cell type 1 response and prognostic marker of long-term nonprogressionQ45053138
Distinct differentiation profiles of HIV-Gag and Nef-specific central memory CD8+ T cells associated with HLA-B57/5801 and virus controlQ45373387
Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rateQ46775963
A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity.Q52841139
Combination of HIV‐1–Specific CD4 Th1 Cell Responses and IgG2 Antibodies Is the Best Predictor for Persistence of Long‐Term NonprogressionQ56837842
Elite control of HIV infection: implications for vaccine designQ56994404
Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to ‘protective’ human leukocyte antigen-B alleles in HIV controllersQ60343375
Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251Q64378954
HIV-1 gp120-specific antibody-dependent cell-mediated cytotoxicity correlates with rate of disease progressionQ71396764
GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serumQ71876491
Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infectionQ74012651
Sustained antibody-dependent cell-mediated cytotoxicity (ADCC) in SIV-infected macaques correlates with delayed progression to AIDSQ78678676
Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectinQ79929623
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)2799-2809
P577publication date2013-12-18
P1433published inJournal of VirologyQ1251128
P1476titleDivergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
P478volume88

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cites work (P2860)
Q33720317A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens
Q64071431Antibody Fab-Fc properties outperform titer in predictive models of SIV vaccine-induced protection
Q33867299Antiviral Functions of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific IgG Antibodies: Effects of Antiretroviral Therapy and Implications for Therapeutic HIV-1 Vaccine Design
Q59808684Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection
Q34204325Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity
Q56974226Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?
Q48222733Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins.
Q33865785Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy
Q88792987Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity
Q36110293Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma
Q38717198Engineering broadly neutralizing antibodies for HIV prevention and therapy
Q42675928Genetic variants of Fcγ (GM allotypes) and the Fc-mediated effector functions in HIV-1 controllers
Q41484708HIV microarray for the mapping and characterization of HIV-specific antibody responses
Q49963941HIV-1 Control and Immunoglobulin Genes
Q52598776HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.
Q92006869IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody
Q30362489Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?
Q47384731Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination
Q50209602Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV.
Q35888710Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control
Q61811072Semen IgM, IgG1, and IgG3 Differentially Associate With Pro-Inflammatory Cytokines in HIV-Infected Men
Q30238729Systems serology for evaluation of HIV vaccine trials
Q46632788Temporal variation in HIV-specific IgG subclass Abs during acute infection differentiates spontaneous controllers from chronic progressors.
Q40163730The association of HIV-1 Gag-specific IgG antibodies with natural control of HIV-1 infection in individuals not carrying HLA-B*57: 01 is only observed in viremic controllers
Q34252448The dysfunction of T follicular helper cells
Q37113972The role of Fc receptors in HIV prevention and therapy
Q35823060Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell-Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification

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