Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN.

scientific article published on 19 January 2017

Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CAM4.954
P932PMC publication ID5313638
P698PubMed publication ID28101903

P50authorMika K KanekoQ90664257
Yukinari KatoQ42292347
P2093author name stringSatoshi Ogasawara
Takuro Nakamura
Michiaki Takagi
Hiroyoshi Suzuki
Shinji Abe
Yasuhiko Nishioka
Hiroyuki Harada
Yuki Fujii
Ryusuke Honma
P2860cites workOverexpression of podoplanin in oral cancer and its association with poor clinical outcomeQ79805143
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumorsQ80551972
Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinomaQ81436908
Characterization of Monoclonal Antibody LpMab-7 Recognizing Non-PLAG Domain of PodoplaninQ85409383
Podoplanin expressing cancer associated fibroblasts are associated with unfavourable prognosis in adenocarcinoma of the esophagusQ85475870
PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplaninQ87199512
LpMab-19 Recognizes Sialylated O-Glycan on Thr76 of Human PodoplaninQ88209080
Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumorsQ24675750
A platform of C-type lectin-like receptor CLEC-2 for binding O-glycosylated podoplanin and nonglycosylated rhodocytinQ27696295
Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational stateQ27704010
Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumorsQ28206434
The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasisQ28221740
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinomaQ28241842
Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cellsQ28269958
Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomasQ28290560
Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progressionQ28305905
Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domainQ28576484
Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.Q30032296
Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor.Q30032661
Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.Q31133789
A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplaninQ33985502
Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomasQ34160649
Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endotheliumQ34502407
Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasisQ34522088
LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-Glycan on Thr52 of Platelet Aggregation-Stimulating Domain of Human PodoplaninQ35975006
The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity.Q36546538
Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumoursQ36617968
Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumorsQ37259430
Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas.Q37562162
Development of Monoclonal Antibody LpMab-10 Recognizing Non-glycosylated PLAG1/2 Domain Including Thr34 of Human Podoplanin.Q38825833
Monoclonal Antibody LpMab-9 Recognizes O-glycosylated N-Terminus of Human PodoplaninQ38825838
Characterization of monoclonal antibody LpMab-3 recognizing sialylated glycopeptide of podoplaninQ38905443
Chimeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity.Q39311213
Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcomaQ39498357
Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progressionQ39537008
Focused differential glycan analysis with the platform antibody-assisted lectin profiling for glycan-related biomarker verificationQ39951477
Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cellsQ40022043
Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2.Q40065992
Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma.Q40399669
Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin.Q40769432
Immunohistochemical Examination of Novel Rat Monoclonal Antibodies against Mouse and Human Podoplanin.Q42002432
Immunohistochemical detection of the lymphatic marker podoplanin in diverse types of human cancer cells using a novel antibody.Q42826024
A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody.Q43934606
IgG3 is the major source of cryoglobulins in mice.Q47897852
Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor.Q48501703
PMab-44 Detects Bovine Podoplanin in Immunohistochemistry.Q51717799
Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti-Aggrus/podoplanin antibodies.Q51766105
Characterization of anti-podoplanin monoclonal antibodies: critical epitopes for neutralizing the interaction between podoplanin and CLEC-2.Q51787002
Podoplanin expressing cancer-associated fibroblasts in oral cancer.Q53027845
Anti-podoplanin Monoclonal Antibody LpMab-7 Detects Metastatic Lesions of Osteosarcoma.Q53462478
Establishment of Mouse Monoclonal Antibody LpMab-13 Against Human Podoplanin.Q53762694
Podoplanin expression by cancer-associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma.Q54333727
P4510describes a project that usesPDIS-6Q54946849
PDIS-9Q54946850
PDIS-1Q54946843
PDIS-12Q54946844
PDIS-14Q54946845
PDIS-2Q54946846
PDIS-22Q54946847
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectCRISPRQ412563
monoclonal antibodyQ422248
Cas9Q16965677
CRISPR-Cas methodQ17310682
cell lineQ21014462
P304page(s)382-396
P577publication date2017-01-19
P1433published inCancer MedicineQ27724564
P1476titleDevelopment and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN.
P478volume6

Reverse relations

described by source (P1343)
Q127382607LN229/hPDPN
Q127382632LpMab-21
Q54946843PDIS-1
Q54946844PDIS-12
Q54946845PDIS-14
Q54946846PDIS-2
Q54946847PDIS-22
Q54946849PDIS-6
Q54946850PDIS-9

cites work (P2860)
Q42292310Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity
Q50351148C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets
Q50162292Development of EMab-51, a Sensitive and Specific Anti-Epidermal Growth Factor Receptor Monoclonal Antibody in Flow Cytometry, Western Blot, and Immunohistochemistry
Q89219422Disodium Cromolyn and Anti-podoplanin Antibodies Strongly Inhibit Growth of BHK 21/C13-derived Fibrosarcoma in a Chick Embryo Chorioallantoic Membrane Model
Q47803240Establishment of CMab-43, a Sensitive and Specific Anti-CD133 Monoclonal Antibody, for Immunohistochemistry.
Q52842322Establishment of EMab-134, a Sensitive and Specific Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Detecting Squamous Cell Carcinoma Cells of the Oral Cavity.
Q53167213H2Mab-77 is a Sensitive and Specific Anti-HER2 Monoclonal Antibody Against Breast Cancer.
Q48367537Plasma soluble podoplanin is a novel marker for the diagnosis of tumor occurrence and metastasis.

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