Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor

scientific article published on 27 February 2014

Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3960761
P698PubMed publication ID24660121

P50authorAntoni X Torres-ColladoQ55080080
P2093author name stringAli R Jazirehi
James S Economou
Ramin Nazarian
P2860cites workClinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
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Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulationsQ29614275
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Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1Q29616128
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Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responsesQ34650346
Proteasome Inhibition Blocks NF-κB and ERK1/2 Pathways, Restores Antigen Expression, and Sensitizes Resistant Human Melanoma to TCR-Engineered CTLsQ36028423
BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapyQ36175312
A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells.Q36926465
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathwayQ37112466
Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanomaQ37727061
Regulation of apoptosis-associated genes by histone deacetylase inhibitors: implications in cancer therapyQ37777312
Resistance patterns with tyrosine kinase inhibitors in melanoma: new insightsQ37982476
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Update on the Targeted Therapy of MelanomaQ38082713
What is new in the treatment of advanced melanoma? State of the art.Q38116006
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.Q39212469
Molecular Mechanism of MART-1+/A*0201+ Human Melanoma Resistance to Specific CTL-Killing Despite Functional Tumor–CTL InteractionQ39619870
MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720.Q39630026
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma modelsQ39692674
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte functionQ39692699
The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrationsQ39803993
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanomaQ39971699
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cellsQ40262620
Role of epidermal growth factor receptor signaling in RAS-driven melanomaQ40427048
Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosisQ40594629
Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cellsQ53302291
Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signalingQ58450931
P433issue1
P921main subjectapoptotic processQ14599311
P304page(s)43-56
P577publication date2014-02-27
P1433published inAmerican journal of clinical and experimental immunologyQ27724357
P1476titleAberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor
P478volume3

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cites work (P2860)
Q33436058A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma.
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Q97074415Histone Deacetylase Inhibitors to Overcome Resistance to Targeted and Immuno Therapy in Metastatic Melanoma
Q26783032Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy
Q47225796Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors
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Q57066104Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo
Q47135020Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade

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