Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy

scientific article published on January 2014

Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/ONCI.27297
P932PMC publication ID3961485
P698PubMed publication ID24701370
P5875ResearchGate publication ID261375478

P50authorGuido KroemerQ19508945
Jérôme GalonQ3190910
Lorenzo GalluzziQ28317088
Laurence ZitvogelQ28317098
Alexander M. M. EggermontQ28317101
Fernando ArandaQ28317121
Erika VacchelliQ40778875
Wolf Hervé FridmanQ40876588
P2860cites workFirst-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meetingQ21198874
Trial WatchQ24618653
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in CancerQ24633070
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.Q24655516
Decoding cell death signals in liver inflammationQ26823299
Trial Watch: Tumor-targeting monoclonal antibodies in cancer therapyQ26993238
Nivolumab plus ipilimumab in advanced melanomaQ27852310
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced CancerQ27860857
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Ipilimumab plus dacarbazine for previously untreated metastatic melanomaQ28131634
PD-L2 is a second ligand for PD-1 and inhibits T cell activationQ28202471
The danger model: a renewed sense of selfQ28214633
Adoptive immunotherapy for cancer: harnessing the T cell responseQ28262548
Hepatotoxicity with combination of vemurafenib and ipilimumabQ28288255
Fcgamma receptors: old friends and new family membersQ28291895
Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibodyQ41474839
Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapyQ41809357
Targeting PD-1/PD-L1 interactions for cancer immunotherapyQ41817131
OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+T cellsQ42060017
High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicatorQ42204309
CTLA-4 blockade synergizes with cryoablation to mediate tumor rejectionQ42214233
Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatmentQ42403366
Trial Watch: Peptide vaccines in cancer therapyQ42734544
Trial Watch: Lenalidomide-based immunochemotherapyQ42737828
IPH-2101, a fully human anti-NK-cell inhibitory receptor mAb for the potential treatment of hematological cancersQ42779465
Trial Watch: Anticancer radioimmunotherapyQ42847992
Trial watch: Dendritic cell-based interventions for cancer therapyQ42867339
Trial Watch: Toll-like receptor agonists for cancer therapyQ42969291
Cisplatin resistance associated with PARP hyperactivationQ43703967
CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphomaQ43864036
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responsesQ44393406
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopiloneQ46507429
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.Q47685354
Monoclonal antibodies: the story of a discovery that revolutionized science and medicineQ47893912
A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemiaQ53351927
Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma.Q53390272
Trial watch: Chemotherapy with immunogenic cell death inducers.Q55658029
Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trialQ56897633
Trial watch: Monoclonal antibodies in cancer therapyQ56932681
Phase I Trial of Multiple Large Doses of Murine Monoclonal Antibody CO17-1A. I. Clinical Aspects1Q68453399
Phase I clinical trial of CO17-1A monoclonal antibodyQ68803677
Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumoursQ72522239
TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieuQ74070676
Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experienceQ74171684
Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinomaQ79346005
The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?Q79990209
Dose and schedule study of panitumumab monotherapy in patients with advanced solid malignanciesQ80556251
A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remissionQ87355944
Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinomaQ93630240
Tolerance, danger, and the extended familyQ29547532
Cancer immunotherapy via dendritic cellsQ29615444
Taking dendritic cells into medicineQ29619243
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlatesQ29620051
Immunogenic Cell Death in Cancer TherapyQ29620118
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancerQ29622818
A phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinomaQ30412791
Complement regulators and inhibitory proteinsQ33386110
Pilot study of dacetuzumab in combination with rituximab and gemcitabine for relapsed or refractory diffuse large B-cell lymphomaQ33402203
A phase 1 study of lucatumumab, a fully human anti‐CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myelomaQ33402671
Immunotherapy: Vaccine trials in melanoma -- time for reflectionQ33434380
The roles of TGFβ in the tumour microenvironmentQ33630845
A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myelomaQ33829132
Complement and its role in innate and adaptive immune responsesQ34088142
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
Monoclonal antibodies: versatile platforms for cancer immunotherapyQ34111693
Immunogenic cell death and DAMPs in cancer therapyQ34311701
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancerQ34362516
OX40 is a potent immune-stimulating target in late-stage cancer patientsQ34381674
Oncogenic stress sensed by the immune system: role of natural killer cell receptorsQ34473267
Transforming growth factor-beta in T-cell biologyQ34572232
Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging studyQ34614776
Toll-like receptors and cancerQ37340298
TGFbeta signalling: a complex web in cancer progressionQ37760038
Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic AntibodiesQ37809159
Molecular mechanisms of the antitumor effects of anti-CD20 antibodiesQ37825142
Molecular mechanisms of cisplatin resistanceQ37926477
OX40 and CD30 signals in CD4+ T‐cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T‐cell memory but not effector functionQ37948124
The secret ally: immunostimulation by anticancer drugsQ37981038
Tremelimumab: a review of development to date in solid tumorsQ38085028
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillanceQ38124438
An immunosurveillance mechanism controls cancer cell ploidyQ39269872
T cell profiling reveals high CD4+CTLA-4+ T cell frequency as dominant predictor for survival after Prostate GVAX/ipilimumab treatmentQ39300005
Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination.Q39457367
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.Q40456758
The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4(+) T cellsQ40725745
Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.Q41219698
Phase I Study of Pembrolizumab (MK-3475; Anti-PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors.Q41228724
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanomaQ34647109
Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell TherapyQ34656292
Identification of tumour-associated T-cell epitopes for vaccine developmentQ34718188
Reassessing target antigens for adoptive T-cell therapyQ34789569
New aspects of natural-killer-cell surveillance and therapy of cancerQ34988265
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunityQ35762422
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40.Q35790354
Trial Watch: Monoclonal antibodies in cancer therapyQ36038408
Trial watch: Chemotherapy with immunogenic cell death inducersQ36038456
Trial Watch: Adoptive cell transfer immunotherapyQ36057432
Trial Watch: Immunostimulatory cytokinesQ36057492
Trial Watch: Experimental Toll-like receptor agonists for cancer therapyQ36194849
Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer PatientsQ36252546
Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cellsQ36373337
Trial watch: FDA-approved Toll-like receptor agonists for cancer therapyQ36373370
Trial watch: Dendritic cell-based interventions for cancer therapyQ36388529
A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myelomaQ36425427
Trial watch: Peptide vaccines in cancer therapyQ36476100
Safety profile and pharmacokinetic analyses of the anti-CTLA4 antibody tremelimumab administered as a one hour infusionQ36527247
Therapeutic potential of immunostimulatory monoclonal antibodiesQ36532194
Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 AntibodyQ36544926
Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumorsQ36643696
Immunostimulatory monoclonal antibodies for cancer therapyQ36717901
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infectionQ36737159
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patientsQ36806268
Trial Watch: Adoptive cell transfer for anticancer immunotherapyQ36887833
Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumoursQ36896203
Negative signaling by inhibitory receptors: the NK cell paradigmQ36983705
Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanomaQ37003295
TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR(+) head and neck cancer cells.Q37028027
Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cellsQ37256962
Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemiaQ37257024
A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinomaQ37325331
The role of TNF superfamily members in T-cell function and diseasesQ37332068
P433issue1
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
P304page(s)e27297
P577publication date2014-01-01
P1433published inOncoImmunologyQ18026500
P1476titleTrial Watch: Immunostimulatory monoclonal antibodies in cancer therapy
P478volume3

Reverse relations

cites work (P2860)
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Q28078725Trial Watch-Immunostimulation with cytokines in cancer therapy
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Q42702234Trial Watch: Adoptive cell transfer for anticancer immunotherapy
Q55260834Trial Watch: Chemotherapy with immunogenic cell death inducers.
Q27004011Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy
Q26996518Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
Q56892924Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy
Q47325431Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications
Q37308207Trial Watch: Immunotherapy plus radiation therapy for oncological indications
Q90326778Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors
Q28082910Trial Watch: Proteasomal inhibitors for anticancer therapy
Q43104064Trial Watch: Radioimmunotherapy for oncological indications
Q33878578Trial Watch: Toll-like receptor agonists in oncological indications
Q27021951Trial Watch:: Oncolytic viruses for cancer therapy
Q27024047Trial watch: Dendritic cell-based anticancer therapy
Q33880165Trial watch: Immunostimulatory cytokines in cancer therapy
Q35798986Trial watch: Naked and vectored DNA-based anticancer vaccines
Q99552010Trial watch: STING agonists in cancer therapy
Q99552005Trial watch: TLR3 agonists in cancer therapy
Q42558833Trial watch: Tumor-targeting monoclonal antibodies for oncological indications
Q64268002Trial watch: dietary interventions for cancer therapy
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