Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

scientific article published on 26 October 2016

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1003125504
P356DOI10.1038/NATURE20131
P932PMC publication ID5317374
P698PubMed publication ID27783593

P50authorDavid T ScaddenQ88652265
Hal E. BroxmeyerQ51754776
P2093author name stringHong Zheng
Gang Huang
Cheng-Kui Qu
Wen-Mei Yu
Lei Dong
Silvia T Bunting
Mignon L Loh
Muxiang Zhou
Melinda Pauly
P2860cites workMutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndromeQ24291893
Hematopoietic stem cell niche maintenance during homeostasis and regenerationQ26865273
Noonan syndromeQ27001641
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutationQ28594140
Inducible gene targeting in miceQ29614544
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxietyQ29615160
Mesenchymal and haematopoietic stem cells form a unique bone marrow nicheQ29616602
Monocyte recruitment during infection and inflammationQ29620067
Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.Q33733273
Chemokines, chemokine receptors and hematopoiesisQ34118764
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.Q34649993
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cellsQ35237519
Endothelial and perivascular cells maintain haematopoietic stem cellsQ35724815
The bone marrow niche for haematopoietic stem cellsQ35887876
Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemiaQ35903505
Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing.Q52085270
Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancerQ64965676
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationQ74742272
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiencyQ35987653
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow nichesQ36691868
The role of Shp2 (PTPN11) in cancer.Q36709740
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiationQ36783485
Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.Q36838533
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesisQ37176577
Arteriolar niches maintain haematopoietic stem cell quiescence.Q37292035
Metalloproteinases and their natural inhibitors in inflammation and immunity.Q38130854
Mesenchymal cell contributions to the stem cell nicheQ38369890
Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent mannerQ38977936
IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia developmentQ39255906
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironmentQ41883433
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow.Q42594348
Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.Q42596867
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.Q42775682
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenanceQ43226905
Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.Q44760563
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamusQ45737931
VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium.Q46289913
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.Q50722204
P4510describes a project that usesImageJQ1659584
P433issue7628
P407language of work or nameEnglishQ1860
P304page(s)304-308
P577publication date2016-10-26
P1433published inNatureQ180445
P1476titleLeukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
P478volume539