| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S11010-009-0318-8 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1007/s11010-009-0318-8 |
| P698 | PubMed publication ID | 20012469 |
| P5875 | ResearchGate publication ID | 40689901 |
| P2093 | author name string | John Garthwaite | |
| P2860 | cites work | Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors | Q24672483 |
| Nitric oxide: physiology, pathophysiology, and pharmacology | Q26778243 | ||
| Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase | Q27627805 | ||
| NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism | Q27641107 | ||
| Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase | Q28188797 | ||
| AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase | Q28283420 | ||
| Functional properties of a naturally occurring isoform of soluble guanylyl cyclase | Q28368954 | ||
| Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase | Q28379365 | ||
| Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme | Q28379416 | ||
| Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes | Q28565964 | ||
| Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding | Q28572045 | ||
| PDE5 is converted to an activated state upon cGMP binding to the GAF A domain | Q28593893 | ||
| Nitric oxide and macrophage function | Q29615327 | ||
| Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations | Q30449094 | ||
| Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors | Q30481191 | ||
| Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells | Q31552489 | ||
| "cAMP-specific" phosphodiesterase contributes to cGMP degradation in cerebellar cells exposed to nitric oxide. | Q31744682 | ||
| Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells | Q31843489 | ||
| NO-independent regulatory site on soluble guanylate cyclase | Q32165040 | ||
| EPR characterization of axial bond in metal center of native and cobalt-substituted guanylate cyclase | Q33177632 | ||
| Characterization of a novel type of endogenous activator of soluble guanylyl cyclase | Q33208407 | ||
| The interactions of adenylate cyclases with P-site inhibitors | Q33650577 | ||
| Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP | Q33948069 | ||
| A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell | Q33949069 | ||
| Nitric oxide: a unique endogenous signaling molecule in vascular biology | Q33963797 | ||
| Phosphodiesterase 5 inhibitors and nitrergic transmission-from zaprinast to sildenafil | Q34118218 | ||
| Allosteric activation of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) by cGMP. | Q34140617 | ||
| A Monte Carlo model reveals independent signaling at central glutamatergic synapses | Q34179022 | ||
| The receptor-like properties of nitric oxide-activated soluble guanylyl cyclase in intact cells. | Q34599899 | ||
| Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels | Q35009484 | ||
| Nitric oxide activation of guanylyl cyclase in cells revisited | Q35033233 | ||
| NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle | Q35044464 | ||
| Properties of NO-activated guanylyl cyclases expressed in cells | Q35045463 | ||
| Membrane-association and the sensitivity of guanylyl cyclase-coupled receptors to nitric oxide | Q35047042 | ||
| Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses | Q35084643 | ||
| Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. | Q35121057 | ||
| Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase | Q35124292 | ||
| Dynamics of cellular NO-cGMP signaling | Q36071783 | ||
| Activation of purified soluble guanylate cyclase by protoporphyrin IX. | Q36293899 | ||
| Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling | Q36324241 | ||
| Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues | Q36410052 | ||
| Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. | Q36622456 | ||
| A molecular basis for nitric oxide sensing by soluble guanylate cyclase | Q36774286 | ||
| Concepts of neural nitric oxide-mediated transmission | Q37029494 | ||
| Mechanisms of activity-dependent plasticity in cellular nitric oxide-cGMP signaling | Q37377637 | ||
| Transphosphorylation and G protein activation | Q37877059 | ||
| Cyclic GMP synthesis and function | Q39167928 | ||
| Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation | Q39218847 | ||
| Probing the presence of the ligand-binding haem in cellular nitric oxide receptors | Q39504233 | ||
| In vivo reconstitution of the negative feedback in nitric oxide/cGMP signaling: role of phosphodiesterase type 5 phosphorylation | Q39968459 | ||
| NO activation of guanylyl cyclase | Q40327686 | ||
| Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission | Q40401503 | ||
| Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272. | Q40569818 | ||
| Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach | Q41765778 | ||
| Superoxide-dependent consumption of nitric oxide in biological media may confound in vitro experiments | Q41974080 | ||
| Heat shock protein 90 regulates stabilization rather than activation of soluble guanylate cyclase | Q42030989 | ||
| Dual effects of intracellular magnesium on muscarinic potassium channel current in single guinea-pig atrial cells | Q42057405 | ||
| Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity | Q42099241 | ||
| YC-1, a novel activator of platelet guanylate cyclase | Q42275468 | ||
| Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | Q42275867 | ||
| Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme | Q42951390 | ||
| Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells | Q43032725 | ||
| Intracellular Mg2+ diffusion within isolated rat skeletal muscle fibers | Q43541200 | ||
| The effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit | Q43774272 | ||
| Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide | Q43911622 | ||
| Inhibition of deactivation of NO-sensitive guanylyl cyclase accounts for the sensitizing effect of YC-1. | Q43972677 | ||
| Differential sensitivity of guanylyl cyclase and mitochondrial respiration to nitric oxide measured using clamped concentrations. | Q44038804 | ||
| YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase | Q44286561 | ||
| BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. | Q44289016 | ||
| Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase | Q44445674 | ||
| [3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. | Q44449939 | ||
| Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41-2272 in human and rabbit corpus cavernosum | Q44602629 | ||
| Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase | Q44626758 | ||
| A new and simple method for delivering clamped nitric oxide concentrations in the physiological range: application to activation of guanylyl cyclase-coupled nitric oxide receptors. | Q44674220 | ||
| Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway | Q44838264 | ||
| Effects of the sGC stimulator BAY 41-2272 are not mediated by phosphodiesterase 5 inhibition | Q45069627 | ||
| An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase | Q46607492 | ||
| Purification and characterization of NO-sensitive guanylyl cyclase | Q46807252 | ||
| Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase | Q46839590 | ||
| Dissociation of nitric oxide from soluble guanylate cyclase | Q46951812 | ||
| Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases | Q47954577 | ||
| IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells | Q50589923 | ||
| Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog. | Q51515778 | ||
| YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. | Q52981674 | ||
| Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase | Q71239563 | ||
| Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators | Q72462196 | ||
| Effect of GTP analogues on purified soluble guanylate cyclase | Q72519691 | ||
| Models of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties | Q72578366 | ||
| A flavoprotein mechanism appears to prevent an oxygen-dependent inhibition of cGMP-associated nitric oxide-elicited relaxation of bovine coronary arteries | Q73204504 | ||
| NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO | Q73279048 | ||
| The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of P-site inhibition | Q73824794 | ||
| Mechanism of YC-1-induced activation of soluble guanylyl cyclase | Q74095219 | ||
| ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells | Q74255264 | ||
| Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand | Q74378137 | ||
| Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes | Q74582058 | ||
| Fluorescent sensors for rapid monitoring of intracellular cGMP | Q82043755 | ||
| P433 | issue | 1-2 | |
| P921 | main subject | pharmacology | Q128406 |
| P304 | page(s) | 221-232 | |
| P577 | publication date | 2009-12-11 | |
| P1433 | published in | Molecular and Cellular Biochemistry | Q1573176 |
| P1476 | title | New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications | |
| P478 | volume | 334 |
| Q58695537 | Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer |
| Q35079061 | Behavioral responses to hypoxia and hyperoxia in Drosophila larvae: molecular and neuronal sensors |
| Q37972853 | CO metabolism, sensing, and signaling |
| Q37138417 | Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock |
| Q37167314 | Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome |
| Q55642775 | From curiosity to applications. A personal perspective on inorganic photochemistry. |
| Q38612575 | From synaptically localized to volume transmission by nitric oxide |
| Q26821895 | Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways |
| Q27690861 | Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad |
| Q28477878 | Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity |
| Q42922803 | Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia |
| Q64945105 | Inhibition of endocytosis suppresses the nitric oxide-dependent release of Cl- in retinal amacrine cells. |
| Q48168253 | Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration |
| Q45193014 | Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine |
| Q28567592 | Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? |
| Q87431341 | Long non-coding RNAs: new players in ocular neovascularization |
| Q35378266 | Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase |
| Q38115291 | Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide. |
| Q38153038 | Nitric Oxide-Induced Calcium Release: Activation of Type 1 Ryanodine Receptor, a Calcium Release Channel, through Non-Enzymatic Post-Translational Modification by Nitric Oxide |
| Q90285686 | Nitric oxide as a multimodal brain transmitter |
| Q37845068 | Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproduction |
| Q36717720 | Nitric oxide signaling in the microcirculation |
| Q54441076 | Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy. |
| Q37887771 | Nitric oxide: a guardian for vascular grafts? |
| Q28732676 | Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation |
| Q37789075 | Protein modifications involved in neurotransmitter and gasotransmitter signaling |
| Q39523169 | Rapid and slow nitric oxide responses during conducted vasodilation in the in vivo intestine and brain cortex microvasculatures |
| Q38777323 | Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives |
| Q42361109 | Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide |
| Q64102728 | Role of Modified Atmosphere in Pest Control and Mechanism of Its Effect on Insects |
| Q38204328 | Role of angiotensin modulation in primary headaches |
| Q35053554 | Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats |
| Q28833738 | Signaling and stress: The redox landscape in NOS2 biology |
| Q54619325 | Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation. |
| Q36167665 | Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme |
| Q54472380 | Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide. |
| Q37897234 | Systems biology of HBOC-induced vasoconstriction |
| Q38772751 | The Role of Reactive Oxygen and Nitrogen Species in the Expression and Splicing of Nitric Oxide Receptor |
| Q34389020 | The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide |
| Q39377988 | The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus |
| Q26863770 | The role of nitric oxide in pre-synaptic plasticity and homeostasis |
| Q37588783 | Thiol-Based Redox Modulation of Soluble Guanylyl Cyclase, the Nitric Oxide Receptor |
| Q33924184 | What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology. |
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