ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage

scientific article published on March 2014

ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.2510-12.2014
P932PMC publication ID3965787
P698PubMed publication ID24672010

P2093author name stringStuart A Lipton
Laurence M Brill
Scott R McKercher
Shing Fai Chan
Nobuki Nakanishi
Shu-Ichi Okamoto
Mohd W Akhtar
Rameez Zaidi
Sam Sances
P2860cites workA calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiationQ24305050
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell deathQ24312157
A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineageQ24324031
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosisQ24534050
Peptide and protein sequence analysis by electron transfer dissociation mass spectrometryQ24561920
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortexQ24563497
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous systemQ24650727
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Substrate specificities and identification of putative substrates of ATM kinase family membersQ28141080
DNA double-strand breaks: signaling, repair and the cancer connectionQ28204231
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
MEF2: a calcium-dependent regulator of cell division, differentiation and deathQ28215798
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsQ28235590
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
Transcription factor ATF2 regulation by the JNK signal transduction pathwayQ28305631
The expression of MEF2 genes is implicated in CNS neuronal differentiationQ28511872
bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell deathQ28513006
Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cellsQ28591351
Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient miceQ28593143
Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.Q48049816
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern.Q48226926
Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemiaQ48824906
Function and expression of the Bcl-x gene in the developing and adult nervous system.Q52205401
The ATM-mediated DNA-damage response: taking shape.Q53618038
Expression of a MADS box gene, MEF2D, in neurons of the mouse central nervous system: implication of its binary function in myogenic and neurogenic cell lineagesQ71041807
Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturationQ71978735
RNA interference reveals a requirement for myocyte enhancer factor 2A in activity-dependent neuronal survivalQ74796123
Improved immunodetection of nuclear antigens after sodium dodecyl sulfate treatment of formaldehyde-fixed cellsQ78055164
ATM: from gene to functionQ28611464
ATM and related protein kinases: safeguarding genome integrityQ29547735
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageQ29614218
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATMQ29614843
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Atm-deficient mice: a paradigm of ataxia telangiectasiaQ29619532
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasiaQ30516583
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.Q30868748
Small-molecule activation of neuronal cell fateQ33343568
MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiationQ33796329
Expression and assay of recombinant ATM.Q33979151
Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.Q34087738
ATM Activation by Oxidative StressQ34145092
ATM and ataxia telangiectasiaQ34166198
The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brainQ34352305
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammationQ34419537
ATM, a central controller of cellular responses to DNA damage.Q34425440
Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patientsQ34627156
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Involvement of novel autophosphorylation sites in ATM activationQ34972885
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damageQ35037470
DNA damage and ageing: new-age ideas for an age-old problemQ35153827
Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiationQ35163278
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteinsQ36072177
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in miceQ36249548
Requirement of the MRN complex for ATM activation by DNA damageQ36267304
Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia.Q36857310
Decision tree-driven tandem mass spectrometry for shotgun proteomicsQ37002998
The role of the DNA damage response in neuronal development, organization and maintenanceQ37155140
Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondriaQ37239235
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesisQ37659446
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuliQ40312088
A role for proapoptotic BID in the DNA-damage responseQ40381562
Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?Q41639296
Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometryQ42074039
Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell culturesQ42447104
Elevated oxidative stress in patients with ataxia telangiectasiaQ44127772
The selective detection of mitochondrial superoxide by live cell imagingQ46554007
Proapoptotic BID is an ATM effector in the DNA-damage responseQ46669145
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
DNA damageQ5205747
P304page(s)4640-4653
P577publication date2014-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage
P478volume34