The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure

scientific article published on 15 January 2014

The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.113.209213
P932PMC publication ID3965889
P698PubMed publication ID24431468
P5875ResearchGate publication ID259767863

P2093author name stringAbdel A Abdel-Rahman
Anusha Penumarti
P2860cites workN-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptorQ21093349
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Globular adiponectin elicits neuroprotection by inhibiting NADPH oxidase-mediated oxidative damage in ischemic stroke.Q50917866
What is the natural ligand of GPR55?Q54612629
Arterial baroreflex control of heart rate in the conscious ratQ71202991
Blockade of L-glutamate receptors in the rostral ventrolateral medulla contributes to ethanol-evoked impairment of baroreflexes in conscious ratsQ71954495
Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit modelQ80001226
Enhanced vascular neuronal nitric-oxide synthase-derived nitric-oxide production underlies the pressor response caused by peripheral N-methyl-D-aspartate receptor activation in conscious ratsQ84117637
The G protein-coupled receptor repertoires of human and mouseQ24681045
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effectsQ24681369
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cellsQ28238141
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18Q28252255
Area postrema neurons are modulated by the adipocyte hormone adiponectinQ28577642
The sympathetic control of blood pressureQ30440682
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptorQ33964574
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.Q34087891
Regulation of anandamide tissue levels by N-arachidonylglycineQ34149742
Antagonism of ∆⁹-THC induced behavioral effects by rimonabant: time course studies in ratsQ34197119
Facilitation of myocardial PI3K/Akt/nNOS signaling contributes to ethanol-evoked hypotension in female rats.Q34286770
A GPR18-based signalling system regulates IOP in murine eye.Q34331021
N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal hornQ34356128
Evidence for novel cannabinoid receptorsQ34415409
An endocannabinoid mechanism for stress-induced analgesia.Q34428429
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N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neuronsQ34771846
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Differential engagements of glutamate and GABA receptors in cardiovascular actions of endogenous nNOS or iNOS at rostral ventrolateral medulla of ratsQ35044981
The complexities of the cardiovascular actions of cannabinoidsQ35047093
Brainstem mechanisms of hypertension: role of the rostral ventrolateral medullaQ35118340
Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor responses in conscious rats.Q35223929
Enhanced hemeoxygenase activity in the rostral ventrolateral medulla mediates exaggerated hemin-evoked hypotension in the spontaneously hypertensive rat.Q35265587
Cannabinoid receptors and endocannabinoids: evidence for new players.Q35594830
Enhancement of rostral ventrolateral medulla neuronal nitric-oxide synthase-nitric-oxide signaling mediates the central cannabinoid receptor 1-evoked pressor response in conscious rats.Q35996700
Endocannabinoids: some like it fat (and sweet too).Q37143599
Role of reactive oxygen species in brainstem in neural mechanisms of hypertensionQ37224953
GPR18 in microglia: implications for the CNS and endocannabinoid system signallingQ38007991
The cardio-protective signaling and mechanisms of adiponectin.Q41106096
A fluorometric assay for the measurement of nitrite in biological samples.Q41526007
Complex regional haemodynamic effects of anandamide in conscious ratsQ42111729
N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channelsQ42434213
Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neuronsQ42447206
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.Q43771353
Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive ratsQ43888056
The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive ratsQ44138907
Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.Q44828892
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive ratsQ44875183
Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamideQ45081681
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendocannabinoidsQ10483908
P304page(s)29-38
P577publication date2014-01-15
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleThe novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure
P478volume349

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cites work (P2860)
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Q34186264Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats
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Q46484964The Effect of Chronic Activation of the Novel Endocannabinoid Receptor GPR18 on Myocardial Function and Blood Pressure in Conscious Rats
Q46204521The endocannabinoid system in cardiovascular function: novel insights and clinical implications

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