Expansions of Cytotoxic CD4+CD28- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection

scientific article published on 02 March 2017

Expansions of Cytotoxic CD4+CD28- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection is …
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scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2017.00195
P932PMC publication ID5332470
P698PubMed publication ID28303136

P50authorFlorian KernQ48662601
Alejandra PeraQ57106242
Kevin DaviesQ60665500
P2093author name stringGeorge Morrow
Iain Broadley
P2860cites workFunctional properties of CD4+ CD28- T cells in the aging immune systemQ77162637
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Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium.Q36126324
Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected womenQ36154044
Memory T cell homeostasis and senescence during aging.Q36228528
Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunctionQ36229028
CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patientsQ47438401
Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activityQ47598912
Memory CD4 T cells emerge from effector T-cell progenitorsQ48887186
CD4+ CD28(null) cells are an independent predictor of mortality in patients with heart failure.Q48970700
Effects of drospirenone-ethinylestradiol and/or metformin on CD4(+)CD28(null) T lymphocytes frequency in women with hyperinsulinemia having polycystic ovary syndrome: a randomized clinical trial.Q50976939
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CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality.Q54381201
Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid ArthritisQ56607491
Role of cytomegalovirus sero-status in the development of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetesQ57192476
Activating NK-cell receptors co-stimulate CD4+CD28−T cells in patients with rheumatoid arthritisQ57226743
Expansion of CD4+CD28null T-lymphocytes in diabetic patients: exploring new pathogenetic mechanisms of increased cardiovascular risk in diabetes mellitusQ58230169
Modulation of CD4 + CD28 null T Lymphocytes by Tumor Necrosis Factor-α Blockade in Patients With Unstable AnginaQ58230246
Perturbation of the T-Cell Repertoire in Patients With Unstable AnginaQ58230319
Modulation of CD28 expression with anti-tumor necrosis factor α therapy in rheumatoid arthritisQ61711491
Demonstration of cytomegalovirus (CMV) DNA and anti-CMV response in the synovial membrane and serum of patients with rheumatoid arthritisQ67851543
Cytomegalovirus genomes demonstrated by polymerase chain reaction in synovial fluid from rheumatoid arthritis patientsQ67856997
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Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosisQ75190389
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjectsQ36402863
The repertoire of CD4+ CD28- T cells in rheumatoid arthritisQ36437991
The "silent" global burden of congenital cytomegalovirusQ36558293
Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infectionQ36559592
CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ studyQ36665428
Reduction in the incidence of myocardial infarction in patients with rheumatoid arthritis who respond to anti-tumor necrosis factor alpha therapy: results from the British Society for Rheumatology Biologics RegisterQ36732112
T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the Multi-Ethnic Study of AtherosclerosisQ36974273
Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomesQ37070704
Persistent pathogens linking socioeconomic position and cardiovascular disease in the US.Q37209892
Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES IIIQ37251214
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CD4+ CD28 null T cells in coronary artery disease: when helpers become killersQ37279626
Role of inflammation in atherosclerosis associated with rheumatoid arthritisQ37300182
CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivityQ37354502
Effector and memory CD4+ and CD8+ T cells in the chronic infection process.Q37367660
Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity.Q37689761
Systematic review and meta‐analysis: Anti–tumor necrosis factor α therapy and cardiovascular events in rheumatoid arthritisQ37801353
Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes.Q37867641
Novel risk factors for cardiovascular disease in rheumatoid arthritisQ38098935
The life (and death) of CD4+ CD28(null) T cells in inflammatory diseasesQ38550407
Increased numbers and functional activity of CD56⁺ T cells in healthy cytomegalovirus positive subjectsQ39033893
Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary eventsQ40166868
Cytomegalovirus-Associated CD4(+) CD28(null) Cells in NKG2D-Dependent Glomerular Endothelial Injury and Kidney Allograft DysfunctionQ40278985
Cytomegalovirus-Infected Primary Endothelial Cells Trigger NKG2C+ Natural Killer Cells.Q40698451
Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescenceQ40951277
CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infectionQ41187566
Expansion of unusual CD4+ T cells in severe rheumatoid arthritisQ41496871
Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritisQ41561823
Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cellsQ42050049
Cytomegalovirus-induced effector T cells cause endothelial cell damage.Q42120717
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromesQ42628689
Novel anti-inflammatory effect of statins: reduction of CD4+CD28null T lymphocyte frequency in patients with unstable angina.Q42833030
Autoimmunity induced by human cytomegalovirus in patients with systemic lupus erythematosusQ43218530
Has cytomegalovirus infection any role in the development of atherosclerosis?Q43792385
Clonal expansions in selected TCR BV families of rheumatoid arthritis patients are reduced by treatment with the TNFα inhibitors etanercept and infliximabQ44001527
Replication of human cytomegalovirus in endothelial cellsQ44766098
Cytomegalovirus and immunological aging: the real driver of HIV and heart disease?Q44937735
Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection.Q44987477
Asymptomatic cytomegalovirus infection is associated with increased risk of new-onset diabetes mellitus and impaired insulin release after renal transplantationQ45037412
Targeting CD4+CD28- T cells by blocking CD28 co-stimulationQ45389800
Neopterin, CD4+CD28- lymphocytes and the extent and severity of coronary artery diseaseQ46509810
Characterization of CD4+CD28null T cells in patients with coronary artery disease and individuals with risk factors for atherosclerosisQ46612705
P921main subjectinflammationQ101991
rheumatoid arthritisQ187255
cytotoxicityQ246181
P304page(s)195
P577publication date2017-03-02
P1433published inFrontiers in ImmunologyQ27723748
P1476titleExpansions of Cytotoxic CD4+CD28- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection
P478volume8

Reverse relations

cites work (P2860)
Q90446908Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
Q59355345Altered CD4 T cell immunity in nurses occupationally exposed to viral pathogens
Q64054989CD28 CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection
Q58796708CD28 pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death
Q55459013CMV immune evasion and manipulation of the immune system with aging.
Q41991727Cytomegalovirus (CMV) Epitope-Specific CD4(+) T Cells Are Inflated in HIV(+) CMV(+) Subjects
Q64102310Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis
Q40128250Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells.
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Q50234923Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis
Q45804014The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis.

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