Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial.

scientific article published on 02 February 2017

Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial. is …
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scholarly articleQ13442814

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P5530Altmetric DOI10.1016/S1470-2045(17)30043-8
P6409CORE ID153353730
P6179Dimensions Publication ID1083527635
P356DOI10.1016/S1470-2045(17)30043-8
P953full work available at URLhttp://eprints.whiterose.ac.uk/111465/
P932PMC publication ID5337626
P698PubMed publication ID28163000
P1154Scopus EID2-s2.0-85011388691

P50authorMichael GriffinQ67954767
Elizabeth C SmythQ82087786
Alicia OkinesQ88835488
David CunninghamQ38803238
Jane M. BlazebyQ40019561
P2093author name stringLaura Stevenson
William H Allum
Derek Alderson
Wasat Mansoor
Sally P Stenning
Heike I Grabsch
Ruth E Langley
Thomas Crosby
Fareeda Y Coxon
Stephen J Falk
Sam Rowley
Suzanne Darby
Kate A Sumpter
P2860cites workNeoadjuvant oxaliplatin and capecitabine and bevacizumab without radiotherapy for poor-risk rectal cancer: N-SOG 03 Phase II trial.Q43967231
Phase II study of preoperative concurrent chemoradiotherapy with S-1 plus bevacizumab for locally advanced resectable rectal adenocarcinomaQ44539823
Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trialQ47815963
Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety reportQ61867831
Long-term results of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancerQ80807888
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerQ27860681
No adjustments are needed for multiple comparisonsQ28292261
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerQ29619394
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III studyQ29620647
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trialQ29620687
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trialQ29620917
Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40Q33416887
Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trialQ34627996
Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08Q34662825
Recurrence and survival after pathologic complete response to preoperative therapy followed by surgery for gastric or gastrooesophageal adenocarcinomaQ35034753
Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study).Q35981433
Bevacizumab added to neoadjuvant chemotherapy for breast cancerQ36106083
Neoadjuvant Therapy of DOF Regimen Plus Bevacizumab Can Increase Surgical Resection Ratein Locally Advanced Gastric Cancer: A Randomized, Controlled StudyQ36207040
Neoadjuvant bevacizumab persistently inactivates VEGF at the time of surgery despite preoperative cessationQ36299062
Phase 2 study of preoperative radiation with concurrent capecitabine, oxaliplatin, and bevacizumab followed by surgery and postoperative 5-fluorouracil, leucovorin, oxaliplatin (FOLFOX), and bevacizumab in patients with locally advanced rectal canceQ36750960
Pathological response and safety of two neoadjuvant strategies with bevacizumab in MRI-defined locally advanced T3 resectable rectal cancer: a randomized, noncomparative phase II studyQ38425364
Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trialQ38443954
Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy TrialQ41069109
Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trialQ42677492
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
bevacizumabQ413299
multicenter clinical trialQ6934595
chemotherapyQ974135
phase III clinical trialQ42824827
phase II clinical trialQ42824440
P304page(s)357-370
P577publication date2017-02-03
P1433published inLancet Oncology CommissionQ13747613
P1476titlePeri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial
P478volume18

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