Pharmacophore and Virtual Screening of JAK3 inhibitors

scientific article published on 19 March 2014

Pharmacophore and Virtual Screening of JAK3 inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.6026/97320630010157
P932PMC publication ID3974243
P698PubMed publication ID24748756
P5875ResearchGate publication ID261766503

P2093author name stringMurugesan Rajeswari
Natchimuthu Santhi
Vembu Bhuvaneswari
P2860cites workJanus kinases in immune cell signalingQ24322021
Janus kinase deregulation in leukemia and lymphomaQ26991810
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo modelsQ27683554
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitorsQ27684317
Naphthyl ketones: a new class of Janus kinase 3 inhibitorsQ28374755
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexesQ29616736
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screeningQ29617343
Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomesQ34132778
JAK3 specific kinase inhibitors: when specificity is not enough.Q34173476
PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary resultsQ34584338
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.Q34595205
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placeboQ34989826
Janus kinase-3 dependent inflammatory responses in allergic asthmaQ35031161
Jak3 and the pathogenesis of severe combined immunodeficiencyQ35818891
A new modality for immunosuppression: targeting the JAK/STAT pathwayQ35825869
ZINCPharmer: pharmacophore search of the ZINC databaseQ36088378
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).Q39798321
Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3).Q40190215
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogQ42109929
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.Q43259921
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD miceQ44410698
The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine modelsQ44695040
JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.Q45930112
Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.Q46414034
Modeling water molecules in protein-ligand docking using GOLD.Q46725683
Docking of aminoglycosides to hydrated and flexible RNA.Q51631377
A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosisQ73329964
Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in miceQ74420476
Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3Q80171440
3D-QSAR and molecular docking studies of 1,3,5-triazene-2,4-diamine derivatives against r-RNA: novel bacterial translation inhibitorsQ80971151
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexateQ84127900
P433issue3
P921main subjectvirtual screeningQ4112105
P304page(s)157-163
P577publication date2014-03-19
P1433published inBioinformationQ27721200
P1476titlePharmacophore and Virtual Screening of JAK3 inhibitors
P478volume10

Reverse relations

Q91726846Construction of Quantitative Structure Activity Relationship (QSAR) Models to Predict Potency of Structurally Diversed Janus Kinase 2 Inhibitorscites workP2860

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