Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress

scientific article published on 09 February 2010

Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1007/S12640-010-9154-6
P932PMC publication ID2932888
P698PubMed publication ID20143199
P5875ResearchGate publication ID41417532

P50authorAnthony A. GraceQ28823334
P2860cites workThe subiculum: what it does, what it might do, and what neuroanatomy has yet to tell usQ24675656
Emotion circuits in the brainQ27860733
Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporterQ28141026
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneuronsQ28144567
Child development risk factors for adult schizophrenia in the British 1946 birth cohortQ28241350
Hippocampal damage associated with prolonged glucocorticoid exposure in primatesQ28335993
A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophreniaQ61713924
Clinical studies with dopamine-receptor stimulantsQ67360037
Psychotic complications of long-term levodopa treatment of Parkinson's diseaseQ68057292
Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortexQ69589769
Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamineQ69619989
A comparison of the effects of electrical stimulation of the amygdala and hippocampus on subpallidal output neurons to the pedunculopontine nucleusQ69693665
Schizophrenia: Geneticism and EnvironmentalismQ70677827
Dopamine turnover in schizophrenia before and after haloperidol withdrawal. CSF, plasma, and urine studiesQ71512247
Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studiesQ73815830
Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamusQ74453176
The role of contextual versus discrete drug-associated cues in promoting the induction of psychomotor sensitization to intravenous amphetamine.Q52144466
Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing.Q52943806
Early and late environmental risk factors for schizophreniaQ57403411
Working memory deficits in adult rats after prenatal disruption of neurogenesisQ59668488
Drug addiction, dysregulation of reward, and allostasisQ29616741
A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophreniaQ30465716
Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior.Q30487469
Neuroimaging studies of the hippocampus in schizophreniaQ30666577
Probing the human hippocampus using rCBF: contrasts in schizophreniaQ30666580
Glucocorticoids and hippocampal atrophy in neuropsychiatric disordersQ31811786
Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neuronsQ31969966
A critical review of recent adoption, twin, and family studies of schizophrenia: behavioral genetics perspectivesQ33644551
Increased dopamine transmission in schizophrenia: relationship to illness phasesQ33679807
Complimentary roles for hippocampal versus subicular/entorhinal place cells in coding place, context, and eventsQ33737369
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studiesQ33833648
Schizophrenia: genes and environmentQ33842577
Contextual fear, gestalt memories, and the hippocampusQ33913259
Risk factors for dementia, depression and psychosis in long-standing Parkinson's diseaseQ33917650
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations.Q33918606
The psychology and neurobiology of addiction: an incentive-sensitization viewQ34043729
Stress and depression: possible links to neuron death in the hippocampusQ34134017
Place units in the hippocampus of the freely moving ratQ34181160
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic DrugsQ34192438
The control of firing pattern in nigral dopamine neurons: single spike firingQ34248461
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neuronesQ34255679
Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interactionQ34415424
Modulation of transmitter release via presynaptic cannabinoid receptorsQ34430714
Antipsychotic drug doses and neuroleptic/dopamine receptorsQ34455159
Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficientQ34463410
Imaging dopamine transmission in schizophrenia. A review and meta-analysis.Q34477992
EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.Q34540614
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neuronsQ34597030
Quantified distribution of the noradrenaline innervation in the hippocampus of adult rat.Q35596912
Developmental pathology, dopamine, and stress: a model for the age of onset of schizophrenia symptomsQ36162160
The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addictionQ36478275
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophreniaQ36500321
Role of the ventral subiculum in stress integration.Q36550474
A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophreniaQ37369353
Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case-control studyQ37411253
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activityQ39223366
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective studyQ39680990
Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus.Q39991777
Intermittent versus continuous stimulation: effect of time interval on the development of sensitization or toleranceQ40284568
What does the hippocampus really do?Q40966686
Cerebrospinal Fluid Amine Metabolites in Acute SchizophreniaQ41070554
Is drug use a response to stress?Q41149381
Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugsQ41326381
The role of stress and dopamine-GABA interactions in the vulnerability for schizophreniaQ41581743
Interchangeability of stress and amphetamine in sensitizationQ41630062
Amphetamine activation of hippocampal drive of mesolimbic dopamine neurons: a mechanism of behavioral sensitizationQ41911596
The phasic reward signal of primate dopamine neuronsQ42445324
Organization of CA1 projections to the subiculum: A PHA-L analysis in the ratQ42467841
Striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivoQ42486333
Stress-induced increase in extracellular dopamine in striatum: role of glutamatergic action via N-methyl-D-aspartate receptors in substantia nigraQ42504689
Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons.Q43653441
Cellular mechanisms of infralimbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo.Q43833763
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioningQ43996878
A single exposure to restraint stress induces behavioral and neurochemical sensitization to stimulating effects of amphetamine: involvement of NMDA receptorsQ44053602
Basolateral amygdala efferents to the ventral subiculum preferentially innervate pyramidal cell dendritic spinesQ44528974
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmissionQ44536213
Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosisQ44691029
Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbensQ44938375
Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophyQ45186234
Restraint increases dopaminergic burst firing in awake ratsQ46484686
Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats.Q46486114
The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activationQ46829207
Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia.Q46945434
Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formationQ48120764
The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli.Q48125179
SPECT study of visual fixation in schizophrenia and comparison subjectsQ48170650
Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in ratsQ48193249
Induced oscillations and the distributed cortical sources during the Wisconsin card sorting test performance in schizophrenic patients: new clues to neural connectivityQ48335984
Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivoQ48342256
Cannabinoids reveal importance of spike timing coordination in hippocampal functionQ48364611
Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activityQ48399995
Peri-pubertal maturation after developmental disturbance: a model for psychosis onset in the rat.Q48421003
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine cravingQ48421523
Working memory related gamma oscillations in schizophrenia patientsQ48425014
What does the Edinburgh high-risk study tell us about schizophrenia?Q48436252
Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activityQ48488712
Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs.Q48496728
Amphetamine psychosis: behavioral and biochemical aspectsQ48597445
Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophreniaQ48943477
Influence of novel versus home environments on sensitization to the psychomotor stimulant effects of cocaine and amphetamine.Q51608211
Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: effects of diazepam.Q51612019
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.Q52030475
Interruptions of early cortical development affect limbic association areas and social behaviour in rats; possible relevance for neurodevelopmental disorders.Q52031016
P433issue3-4
P921main subjectschizophreniaQ41112
psychosisQ170082
dopamineQ170304
pathophysiologyQ1135939
P304page(s)367-376
P577publication date2010-02-09
P1433published inNeurotoxicity ResearchQ15764278
P1476titleDopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress
P478volume18

Reverse relations

cites work (P2860)
Q31018164A data-driven approach to mapping cortical and subcortical intrinsic functional connectivity along the longitudinal hippocampal axis
Q35244029A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP.
Q35158189A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia
Q30450082Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis
Q30429962Abnormal stress responsivity in a rodent developmental disruption model of schizophrenia
Q21260315Amphetamine-induced psychosis--a separate diagnostic entity or primary psychosis triggered in the vulnerable?
Q35197029Antipsychotic drugs rapidly induce dopamine neuron depolarization block in a developmental rat model of schizophrenia
Q30405706Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model
Q30473410Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia
Q37147730Cannabis Use and Associated Harms among Schizophrenia Patients in a Nigerian Clinical Setting: A Case-Control Study
Q36521481Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia
Q30469676Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
Q45768490Cognitive correlates of psychosis in patients with Parkinson's disease
Q37299372Dissociated Accumbens and Hippocampal Structural Abnormalities across Obesity and Alcohol Dependence
Q36367159Dopamine synthesis and D3 receptor activation in pancreatic β-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations
Q37881426Dopamine system dysregulation by the hippocampus: implications for the pathophysiology and treatment of schizophrenia
Q30416848Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia
Q36342879Effects of city living on the mesolimbic reward system-An fmri study.
Q37911589Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference.
Q37711120Epigenetics and biomarkers in the staging of neuropsychiatric disorders
Q35612943Evidence for an anterior-posterior differentiation in the human hippocampal formation revealed by meta-analytic parcellation of fMRI coordinate maps: focus on the subiculum
Q26830603Following the genes: a framework for animal modeling of psychiatric disorders
Q30473855Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?
Q38630671Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies
Q91891538Interplay between midbrain and dorsal anterior cingulate regions arbitrates lingering reward effects on memory encoding
Q47779741Lower Fractional Anisotropy in the Gray Matter of Amygdala-Hippocampus-Nucleus Accumbens Circuit in Methamphetamine Users: an In Vivo Diffusion Tensor Imaging Study
Q27315950Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
Q38176606Neural and behavioral substrates of subtypes of Parkinson's disease
Q48139337Phytocannabinoids modulate emotional memory processing through interactions with the ventral hippocampus and mesolimbic dopamine system: implications for neuropsychiatric pathology.
Q38139358Possible contributions of a novel form of synaptic plasticity in Aplysia to reward, memory, and their dysfunctions in mammalian brain
Q37511471Region-specific upregulation of parvalbumin-, but not calretinin-positive cells in the ventral hippocampus during adolescence
Q93154482Resilience to adversity is associated with increased activity and connectivity in the VTA and hippocampus
Q36210656Schizophrenia: from epidemiology to rehabilitation
Q26830600Stress and neurodevelopmental processes in the emergence of psychosis
Q28552655The Role of Social Novelty in Risk Seeking and Exploratory Behavior: Implications for Addictions
Q30447851Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals

Search more.