AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.

scientific article published on 19 June 2013

AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2013.134
P932PMC publication ID3978810
P698PubMed publication ID23778424
P5875ResearchGate publication ID239947360

P50authorJames WilsonQ16947166
Alison CrawfordQ57286336
Lili WangQ64356065
E. John WherryQ88954779
P2093author name stringPeter Bell
Jianping Lin
Lauren E Mays
P2860cites workViral immune evasion due to persistence of activated T cells without effector functionQ24646943
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Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicityQ33490137
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Induction of immune tolerance to FIX by intramuscular AAV gene transfer is independent of the activation status of dendritic cellsQ33608746
Regulatory T cells and immune tolerance to coagulation factor IX in the context of intramuscular AAV1 gene transferQ33730693
CD8 cells of patients with diffuse cutaneous leishmaniasis display functional exhaustion: the latter is reversed, in vitro, by TLR2 agonists.Q33745224
Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibersQ33782809
CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cellsQ33810726
AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cellsQ33931609
Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cellsQ34574858
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Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors.Q36085709
Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in miceQ36144935
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Tr1 cells: from discovery to their clinical application.Q36390028
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Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindnessQ36825024
Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapyQ37066228
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The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in miceQ37286686
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Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transferQ41920883
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.Q41972673
Vaccines based on novel adeno-associated virus vectors elicit aberrant CD8+ T-cell responses in miceQ42121728
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytesQ43205921
Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapyQ43801966
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectorsQ45299117
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteinsQ45384856
Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transferQ45874902
An optimized protocol for detection of E. coli beta-galactosidase in lung tissue following gene transfer.Q45884158
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivoQ47765780
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 toleranceQ47817407
Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX into mouse liverQ48004746
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Q51970485
Innate immune recognition and control of adaptive immune responsesQ77502590
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectT cell exhaustionQ56649209
P304page(s)28-41
P577publication date2013-06-19
P1433published inMolecular TherapyQ15762400
P1476titleAAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells
P478volume22

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