Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice

scientific article published on 02 March 2017

Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.REDOX.2017.02.020
P932PMC publication ID5344326
P698PubMed publication ID28282614

P2093author name stringLi Yang
Hua Wang
Wen-Xing Ding
Hiromi Sesaki
Xiao Yang
Zhengtao Wang
Hong-Min Ni
Aizhen Xiong
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A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in ratsQ44565367
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Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive diseaseQ71048227
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Metabolic regulation of mitochondrial dynamicsQ26768130
Mitophagy: mechanisms, pathophysiological roles, and analysisQ26865743
Mdv1 interacts with assembled dnm1 to promote mitochondrial divisionQ27933197
CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulationQ28279133
Mitochondrial dynamics and mitochondrial quality controlQ28386855
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesQ28392033
Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in MiceQ28392505
Mitochondrial fission, fusion, and stressQ29616536
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosisQ29616568
Pyrrolizidine alkaloid plants, metabolism and toxicityQ33544828
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS releaseQ33913079
Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanismsQ34312030
Mitochondrial dynamics and inheritance during cell division, development and diseaseQ34600662
JNK signaling in apoptosisQ34713366
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brainQ34806899
A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retinaQ34937163
Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloidsQ35202947
Activation of autophagy protects against acetaminophen-induced hepatotoxicityQ35631643
Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in miceQ36017834
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicityQ36853583
Functions of autophagy in normal and diseased liverQ37107125
Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetumQ37819241
Tusanqi and hepatic sinusoidal obstruction syndromeQ38188085
Hepatotoxicity of Pyrrolizidine AlkaloidsQ38655359
Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular FunctionQ38669205
Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicityQ39822299
Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytesQ39967296
P921main subjectmitochondrionQ39572
P304page(s)264-273
P577publication date2017-03-02
P1433published inRedox BiologyQ27724751
P1476titleInhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice
P478volume12

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cites work (P2860)
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