Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors

scientific article published on 16 September 2013

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JM400932C
P932PMC publication ID3982121
P698PubMed publication ID23987476
P5875ResearchGate publication ID256288815

P50authorYves PommierQ28320644
Ettore NovellinoQ38359645
Luciana MarinelliQ39061698
Sandro CosconatiQ39061714
Silvia SalernoQ46615312
Anna Maria MariniQ46615325
Francesco Saverio Di LevaQ52585400
Roberto Di SantoQ54667214
Concettina La MottaQ56550100
Sabrina TalianiQ57119654
Christophe H MarchandQ57421220
Elisabetta BarresiQ58863181
Federico Da Settimo PassettiQ58982862
Francesca SimoriniQ61037557
Isabella PugliesiQ114517382
P2093author name stringKeli Agama
P2860cites workCellular roles of dna topoisomerases: a molecular perspectiveQ22121990
Drugging topoisomerases: lessons and challengesQ27000099
Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analogQ27639935
Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I PoisonQ29394250
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionQ29400901
A semiempirical free energy force field with charge-based desolvationQ29614316
Topoisomerase I inhibitors: camptothecins and beyondQ29614976
One-pot microwave assisted preparation of pyrazoloquinazolinone librariesQ33197880
Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.Q34564807
Repair of topoisomerase I-mediated DNA damageQ36557533
Targeting DNA topoisomerase I with non-camptothecin poisons.Q37971946
Dialkylaminoalkylindolonaphthyridines as potential antitumour agents: synthesis, cytotoxicity and DNA binding propertiesQ40707457
A force field with discrete displaceable waters and desolvation entropy for hydrated ligand dockingQ42557837
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases IQ44652194
Benzothiopyranoindole-Based Antiproliferative Agents: Synthesis, Cytotoxicity, Nucleic Acids Interaction, and Topoisomerases Inhibition PropertiesQ58855736
The structural basis of camptothecin interactions with human serum albumin: impact on drug stabilityQ72726302
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)7458-7462
P577publication date2013-09-16
P1433published inJournal of Medicinal ChemistryQ900316
P1476titlePhenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors
P478volume56

Reverse relations

cites work (P2860)
Q93166626Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidine-Based Antiproliferative Multikinase Inhibitors
Q38882751Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore
Q48271013Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study.
Q57062310Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
Q64939460Synthesis and cytotoxic evaluation of novel quinozalinone derivatives with substituted benzimidazole in position 3.

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