Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways

scientific article

Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.13687
P932PMC publication ID5352206
P698PubMed publication ID27906672

P2093author name stringLi Yang
Jia Hu
Xiang Chen
Li Wan
Chunyu Wang
Hong Luo
Aihua Peng
Lijuan Chen
Yuquan Wei
Haoyu Ye
Jianhong Yang
Qiang Qiu
Ximing Shao
Wenshuang Wu
Chengjian Zhao
Afu Fu
Heying Pei
Hansuo Yang
LuLu Chai
P2860cites workRac and Rho GTPases in cancer cell motility controlQ21245504
TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathwaysQ89700432
Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicityQ24648175
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosisQ24669763
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoQ28180577
Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species productionQ28185379
VEGF-D promotes the metastatic spread of tumor cells via the lymphaticsQ28200072
Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatographyQ28283348
Dissemination and growth of cancer cells in metastatic sitesQ29555846
The microenvironment of the tumour-host interfaceQ29620375
Epirubicin, cisplatin, 5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinomaQ33412612
Antimicrobial Activity of Phenolic Constituents of Magnolia Grandiflora LQ34284380
Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasisQ34615993
The prognostic molecular markers in hepatocellular carcinomaQ34668320
The cell surface: the stage for matrix metalloproteinase regulation of migrationQ34858318
Metastasis suppressors alter the signal transduction of cancer cellsQ35037682
Translational strategies for cancer prevention in liver.Q35118721
Role of the PI3K regulatory subunit in the control of actin organization and cell migrationQ36366957
Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO.Q36496451
Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical studyQ37153412
Recent advances in the natural history of hepatocellular carcinomaQ37178623
The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironmentQ37595291
Conserved F-actin dynamics and force transmission at cell adhesionsQ37781561
Why does cancer therapy lack effective anti-metastasis drugs?Q38051530
Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytesQ38903877
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.Q39500189
Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor modelQ39883496
Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cellsQ39896830
Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer modelsQ39969746
Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis inductionQ40012007
Enhancement of therapeutic effectiveness by combining liposomal honokiol with cisplatin in ovarian carcinomaQ40076871
Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitroQ43814720
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cellsQ43990741
Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activityQ46949401
Two antiplatelet agents from Magnolia officinalis.Q47379482
Distinct contributions of angiogenesis and vascular co-option during the initiation of primary microtumors and micrometastases.Q50522226
Studies on Inhibitors of Skin Tumor Promotion, IX. Neolignans from Magnolia officinalisQ53499070
Extrahepatic Metastases of Hepatocellular CarcinomaQ56172243
Hepatocellular carcinomaQ57696098
Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effectsQ71153875
Honokiol induces apoptosis in human lymphoid leukemia Molt 4B cellsQ77672276
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathwayQ80243492
Therapeutic targeting of the tumor microenvironmentQ81839382
P4510describes a project that usesImageQuantQ112270642
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)915-932
P577publication date2016-11-29
P1433published inOncotargetQ1573155
P1476titleNon-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways
P478volume8

Reverse relations

cites work (P2860)
Q48206047Application of EGFR inhibitor reduces circulating tumor cells during transcatheter arterial embolization.
Q90043621Modeling of Solid-Tumor Microenvironment in Zebrafish (Danio Rerio) Larvae
Q90381364Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
Q48508092Synthesis of magnolol and honokiol derivatives and their effect against hepatocarcinoma cells.