Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections

scientific article published on 14 April 2014

Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1003395530
P356DOI10.1186/1475-2875-13-141
P932PMC publication ID3989846
P698PubMed publication ID24731238
P5875ResearchGate publication ID261732761

P50authorMark HickmanQ43186320
P2093author name stringJing Zhang
Qiang Zeng
Lisa Xie
Qigui Li
Victor Melendez
Brandon Pybus
Diana Caridha
Michael O'Neil
P2860cites workVisualisation and quantitative analysis of the rodent malaria liver stage by real time imagingQ27335248
Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryQ27861956
A new primaquine analogue, tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malariaQ28204425
8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat modelsQ28335570
In vivo imaging of malaria parasites in the murine liverQ33291322
Randomized, double-blind study of the safety, tolerability, and efficacy of tafenoquine versus mefloquine for malaria prophylaxis in nonimmune subjectsQ33613720
Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial.Q33696465
Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoeliiQ34674176
Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasitesQ35761522
4(1H)-Quinolones with liver stage activity against Plasmodium berghei.Q36505423
Tafenoquine: a promising new antimalarial agentQ36802630
Quantitative analysis of Plasmodium berghei liver stages by bioluminescence imagingQ39276004
In vitro activity of tafenoquine alone and in combination with artemisinin against Plasmodium falciparumQ39381337
Antimalarial activity of novel 5-aryl-8-aminoquinoline derivativesQ39622533
Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapseQ41913336
Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in ThailandQ41923249
Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunizationQ41927711
The efficacy of WR238605 against the blood stages of a chloroquine resistant strain of Plasmodium vivaxQ41934435
The chemotherapy of rodent malaria. LI. Studies on a new 8-aminoquinoline, WR 238,605.Q41936641
Gametocytocidal and sporontocidal activity of antimalarials against Plasmodium berghei ANKA in ICR Mice and Anopheles stephensi mosquitoesQ44142648
Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.Q44158438
Simple Centrifugation Method for Rapid Separation of Sporozoites from MosquitoesQ44164986
Plasmodium liver load following parenteral sporozoite administration in rodentsQ44166267
A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparumQ44320940
Comparison of tafenoquine (WR238605) and primaquine in the post-exposure (terminal) prophylaxis of vivax malaria in Australian Defence Force personnelQ44354530
Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malariaQ45056153
Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO-1.Q47823279
Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria.Q47830770
First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial.Q47831031
Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasitesQ47915637
Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in ratsQ68054030
In vitro effects of primaquine and primaquine metabolites on exoerythrocytic stages of Plasmodium bergheiQ68468347
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
pharmacokineticsQ323936
P304page(s)141
P577publication date2014-04-14
P1433published inMalaria JournalQ15749954
P1476titleAssessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections
P478volume13

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cites work (P2860)
Q47627038A newly validated high-performance liquid chromatography method with diode array ultraviolet detection for analysis of the antimalarial drug primaquine in the blood plasma
Q47764632Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.
Q62125563Approval of Tafenoquine for Malaria Chemoprophylaxis
Q40388332Artesunate-tafenoquine combination therapy promotes clearance and abrogates transmission of the avian malaria parasite Plasmodium gallinaceum.
Q37480757Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei
Q35746028Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics
Q92249482Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials
Q34646141Efficacy and safety of artemisinin combination therapy (ACT) for non-falciparum malaria: a systematic review
Q28085135Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research
Q30976084Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh
Q50054503Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen
Q35692516Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy
Q37712176Interactions between tafenoquine and artemisinin-combination therapy partner drug in asexual and sexual stage Plasmodium falciparum
Q28081463Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax
Q33607991Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites.
Q57465375Nanomedicines for Malaria Chemotherapy: Encapsulation vs. Polymer Therapeutics
Q36907360Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants
Q64996994Primaquine-quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species.
Q37287860Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.
Q26741307Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date
Q92315822Tafenoquine: A 2018 Novel FDA-Approved Prodrug for the Radical Cure of Plasmodium vivax Malaria and Prophylaxis of Malaria
Q38774112The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg).
Q64245769Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria

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