Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation

scientific article published on 27 March 2017

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation is …
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scholarly articleQ13442814

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P356DOI10.1038/SREP45275
P932PMC publication ID5366889
P698PubMed publication ID28345638

P2093author name stringLan Wang
Jie Zhang
Hao Wu
Mingming Zhang
Jianxin Gu
Can Li
Junjie Zhao
Weicheng Wu
Lili Li
Ran Zhao
Yuanyuan Ruan
Caiting Yang
Peike Peng
Shushu Song
Miaomiao Shao
P2860cites workThe Hallmarks of CancerQ221226
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Identification of soluble forms of lectin-like oxidized LDL receptor-1Q73536903
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Clinicopathological features and overexpression of matrix metalloproteinases in intramucosal gastric carcinoma with lymph node metastasisQ74352312
Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gammaQ80097966
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosisQ80976759
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritisQ82470746
Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary syndrome--comparison with other biomarkersQ84531189
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The heat-shock proteinsQ29617227
Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbitsQ30857720
Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52EQ30990551
Heat Shock Protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survivalQ33407026
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseasesQ33789567
Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancerQ33921431
Lectin-like oxidized LDL receptor-1 is an enhancer of tumor angiogenesis in human prostate cancer cellsQ34110474
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CRP enhances soluble LOX-1 release from macrophages by activating TNF-α converting enzymeQ34769808
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Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesisQ37845394
Angiogenesis is a link between atherosclerosis and tumorigenesis: role of LOX-1.Q37942011
Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis.Q38094977
Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategiesQ38724851
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase SubunitsQ38795616
Oxidized low-density lipoprotein is associated with advanced-stage prostate cancer.Q38922391
Metadherin regulates metastasis of squamous cell carcinoma of the head and neck via AKT signalling pathway-mediated epithelial-mesenchymal transitionQ39085259
Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36.Q39147757
Clinicopathological significance of E-cadherin, VEGF, and MMPs in gastric cancerQ43011998
Significance of expression of heat shock protein90α in human gastric cancerQ43159642
Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE.Q43748572
Ginkgo biloba extract inhibits oxidized low-density lipoprotein (oxLDL)-induced matrix metalloproteinase activation by the modulation of the lectin-like oxLDL receptor 1-regulated signaling pathway in human umbilical vein endothelial cellsQ44217718
Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1).Q46565716
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
P304page(s)45275
P577publication date2017-03-27
P1433published inScientific ReportsQ2261792
P1476titleLectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation
P478volume7

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cites work (P2860)
Q50351148C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets
Q90055176C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity
Q58111949CRP and LOX-1: a Mechanism for Increasing the Tumorigenic Potential of Colorectal Cancer Carcinoma Cell Line
Q47779642Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
Q92309753LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline
Q93075429Low profile high value target: The role of OxLDL in cancer
Q54218400Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype.
Q93357281OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF‑C expression and secretion
Q90682133Targeting LOX-1 Inhibits Colorectal Cancer Metastasis in an Animal Model

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