| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Leonard P. Guarente | Q6525606 |
| P2093 | author name string | Gizem Donmez | |
| P2860 | cites work | DBC1 is a negative regulator of SIRT1 | Q24309055 |
| Negative regulation of the deacetylase SIRT1 by DBC1 | Q24309090 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 285-290 | |
| P577 | publication date | 2010-04-01 | |
| P1433 | published in | Aging Cell | Q2221073 |
| P1476 | title | Aging and disease: connections to sirtuins | |
| P478 | volume | 9 |
| Q35590452 | 'Relax and Repair' to restrain aging. |
| Q38838748 | A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling |
| Q24314096 | A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex |
| Q35019751 | A pharmacological network for lifespan extension in Caenorhabditis elegans |
| Q34187339 | Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. |
| Q34852226 | Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. |
| Q27930160 | Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction |
| Q40370463 | Activation of silent mating type information regulation 2 homolog 1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and inflammation |
| Q37178500 | Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle. |
| Q41814482 | Aging and vascular dysfunction: beneficial melatonin effects. |
| Q38847003 | Air Pollution Stress and the Aging Phenotype: The Telomere Connection. |
| Q37674810 | An aging-independent replicative lifespan in a symmetrically dividing eukaryote. |
| Q40077540 | Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. |
| Q49871081 | Association of SIRT-1 Gene Polymorphism and Vitamin D Level in Egyptian Patients With Rheumatoid Arthritis. |
| Q37077703 | Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study |
| Q91726609 | Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and β-catenin acetylation in bladder cancer cells |
| Q39119372 | Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism |
| Q34278921 | Cardiac-targeting magnetic lipoplex delivery of SH-IGF1R plasmid attenuate norepinephrine-induced cardiac hypertrophy in murine heart |
| Q36245247 | Classifying aging as a disease in the context of ICD-11. |
| Q35617534 | Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage |
| Q33784446 | Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders |
| Q41773152 | Controlling SIRT1 expression by microRNAs in health and metabolic disease |
| Q64060551 | Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response |
| Q41951900 | Death by transposition - the enemy within? |
| Q38542963 | Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes |
| Q48262628 | Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. |
| Q48951275 | Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain. |
| Q39538291 | Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD(+) level, SIRT1 activity and replicative lifespan of human Hs68 cells |
| Q37179872 | Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction |
| Q33764597 | Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy? |
| Q37524071 | Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence |
| Q38628089 | Endothelium-dependent hyperpolarization: age, gender and blood pressure, do they matter? |
| Q55249482 | Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat. |
| Q35950832 | Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. |
| Q92316611 | Evaluation of the Common Molecular Basis in Alzheimer's and Parkinson's Diseases |
| Q38723216 | Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. |
| Q27304617 | Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation. |
| Q41425301 | Fortifying the link between SIRT1, resveratrol, and mitochondrial function |
| Q34568424 | FoxO1 mediates an autofeedback loop regulating SIRT1 expression |
| Q24304894 | HDAC3 is negatively regulated by the nuclear protein DBC1 |
| Q36388459 | Healthspan Pharmacology |
| Q36217330 | Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans |
| Q35134204 | Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice |
| Q87675310 | Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells |
| Q35318592 | Hypothalamic inflammation: a double-edged sword to nutritional diseases |
| Q34372194 | Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities |
| Q37619653 | Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle |
| Q34989691 | Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance |
| Q39180915 | Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes. |
| Q36450391 | Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling |
| Q41658322 | Intrinsic Versus Extrinsic Cancer Risk Factors and Aging |
| Q38662343 | Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation |
| Q42431187 | Longevity as a matter of housekeeping. |
| Q48602169 | Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy |
| Q48559380 | Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid |
| Q37872821 | Mammalian Sirt1: insights on its biological functions |
| Q38900962 | Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype |
| Q35917385 | Mating-type genes and MAT switching in Saccharomyces cerevisiae |
| Q35661981 | Metabolism as a key to histone deacetylase inhibition |
| Q26992212 | Metabolism, longevity and epigenetics |
| Q21135290 | Methods for structuring scientific knowledge from many areas related to aging research |
| Q36802020 | MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4 |
| Q31115984 | Minimally invasive bipolar fractional radiofrequency treatment upregulates anti-senescence pathways |
| Q36638143 | Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. |
| Q38019568 | Mitochondrial sirtuins--a new therapeutic target for repair and protection in multiple sclerosis |
| Q46979106 | Model-based identification of drug targets that revert disrupted metabolism and its application to ageing |
| Q37708543 | Modulation of cell cycle regulators by HDACs |
| Q38844786 | Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α. |
| Q43088198 | N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging |
| Q34711930 | Natural variation for lifespan and stress response in the nematode Caenorhabditis remanei |
| Q35188224 | New comparative genomics approach reveals a conserved health span signature across species |
| Q35088919 | New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide |
| Q33721511 | Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion |
| Q39496015 | Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals |
| Q37564661 | Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention |
| Q37994355 | Nutrient sensing and the circadian clock |
| Q28389690 | Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss |
| Q41845246 | Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation |
| Q60916934 | Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT |
| Q40473718 | Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. |
| Q36386750 | Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways |
| Q37823690 | Re-evaluating the general(ized) roles of AMPK in cellular metabolism |
| Q41359355 | Reduced activity of SKC a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats |
| Q37617643 | Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis |
| Q41228873 | Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation |
| Q34016965 | Repair of endogenous DNA base lesions modulate lifespan in mice |
| Q38009762 | Resveratrol and health: the starting point |
| Q38889012 | Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice |
| Q34643236 | Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis |
| Q33789303 | Role of transcription factor acetylation in diabetic kidney disease |
| Q38209461 | Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress |
| Q93017697 | SIRT1 Knockdown Enhances the Differentiation of Human Embryonic Stem Cells into Pancreatic β Cells |
| Q53629703 | SIRT1 Protects Against Oxidative Stress-Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation. |
| Q35782076 | SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing |
| Q37815730 | SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model |
| Q26864929 | SIRT1 and SIRT2: emerging targets in neurodegeneration |
| Q35709871 | SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity |
| Q35152218 | SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL |
| Q34542060 | SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse |
| Q37301790 | SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis |
| Q34272924 | SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function |
| Q24337223 | SIRT1 links CIITA deacetylation to MHC II activation |
| Q36005375 | SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice |
| Q35686386 | SIRT1 protects against α-synuclein aggregation by activating molecular chaperones |
| Q36685949 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. |
| Q24601406 | SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. |
| Q37436106 | SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis |
| Q51567947 | SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal. |
| Q39634508 | SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis |
| Q42780150 | SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway |
| Q34373638 | SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis |
| Q48392766 | SIRT3 attenuates MPTP-induced nigrostriatal degeneration via enhancing mitochondrial antioxidant capacity |
| Q41970498 | SIRT3: Striking at the heart of aging |
| Q88914346 | SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation |
| Q39499402 | Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. |
| Q38889552 | Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro. |
| Q35803676 | Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction |
| Q33637249 | Significance of epigenetic landscape in cartilage regeneration from the cartilage development and pathology perspective |
| Q40926121 | Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway. |
| Q34852306 | SirT1 brings stemness closer to cancer and aging |
| Q36751963 | Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice |
| Q36545639 | Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells |
| Q37865873 | Sirt1's systemic protective roles and its promise as a target in antiaging medicine |
| Q29619949 | Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction |
| Q35003686 | Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction |
| Q34023370 | Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells |
| Q36294810 | Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein |
| Q38099602 | Sirtuin 6: a review of biological effects and potential therapeutic properties |
| Q34742199 | Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. |
| Q34024712 | Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena |
| Q38078763 | Sirtuins in dermatology: applications for future research and therapeutics |
| Q38108575 | Sirtuins' modulation of autophagy |
| Q42993173 | Steroid boost for sirtuin research |
| Q34206342 | Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography |
| Q27022690 | T cell replicative senescence in human aging |
| Q46295983 | The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes |
| Q58805053 | The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer's Diseased Mice Hearts |
| Q39242629 | The Role of ADAM10 in Alzheimer's Disease |
| Q90400188 | The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging |
| Q28244138 | The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS |
| Q38180970 | The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling. |
| Q34242709 | The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). |
| Q35034408 | The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin |
| Q37903980 | The potential role of epigenetic responses to diet in ageing |
| Q46603036 | The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS. |
| Q30540850 | The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells |
| Q26781186 | The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives |
| Q38098174 | The role of sirtuins in Alzheimer's disease |
| Q36501584 | The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models |
| Q35458082 | The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun |
| Q26998468 | Transcriptional integration of mitochondrial biogenesis |
| Q42374228 | Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice. |
| Q37716546 | Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells |
| Q37649607 | Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs |
| Q38963905 | Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells |
| Q45211310 | Upregulation of Sirt1 in carbon-tetrachloride-induced acute liver injury. |
| Q46300548 | Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis |
| Q37251985 | When is Sirt1 activity bad for dying neurons? |
| Q34554291 | Why the disposable soma theory cannot explain why women live longer and why we age. |
| Q34051632 | Yeast replicative aging: a paradigm for defining conserved longevity interventions |
| Q34229899 | mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart. |
| Q35709311 | p63-microRNA feedback in keratinocyte senescence |
| Q91736368 | α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice |
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