review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1007/S12035-010-8134-4 |
P698 | PubMed publication ID | 20429043 |
P50 | author | Alison Colquhoun | Q55640888 |
P2093 | author name string | Alison Colquhoun | |
P2860 | cites work | High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase | Q24561487 |
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy | Q24646296 | ||
The 2007 WHO classification of tumours of the central nervous system | Q24685772 | ||
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen | Q28249524 | ||
Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation | Q28345547 | ||
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase | Q28366319 | ||
Mechanisms of action of eicosapentaenoic acid in bladder cancer cells in vitro: alterations in mitochondrial metabolism, reactive oxygen species generation and apoptosis induction | Q46112285 | ||
Identification of new tyrosine phosphorylated proteins in rat brain mitochondria | Q46709147 | ||
The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes | Q48104003 | ||
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme | Q48251009 | ||
Profiles of the fatty acids in the plasma membrane of human brain tumors | Q48296723 | ||
Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes | Q48388052 | ||
Apoptosis in human primary brain tumours: actions of arachidonic acid | Q48457784 | ||
Intratumoral gamma-linoleic acid therapy of human gliomas | Q48513503 | ||
The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue | Q48848942 | ||
Regulation of cell division in a human glioma cell clone by arachidonic acid and alpha-tocopherolquinone | Q49012394 | ||
Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo. | Q53461247 | ||
Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion. | Q53480704 | ||
Ku is involved in cell growth, DNA replication and G1-S transition. | Q53500086 | ||
Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation. | Q53611015 | ||
Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. | Q53894867 | ||
Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? | Q54146198 | ||
Effect of n-6 and n-3 fatty acids on the survival of vincristine sensitive and resistant human cervical carcinoma cells in vitro. | Q54197319 | ||
The selective cytotoxicity of gamma-linolenic acid (GLA) is associated with increased oxidative stress. | Q55476170 | ||
Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels. | Q55476402 | ||
Specific fatty acids and human colorectal cancer: an overview | Q56779690 | ||
Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation | Q59626883 | ||
Inhibition of the Expression of VE-Cadherin/Catenin Complex by Gamma Linolenic Acid in Human Vascular Endothelial Cells, and Its Impact on Angiogenesis | Q61857429 | ||
Mitochondrial medicine and mitochondrion-based therapeutics☆ | Q62398519 | ||
Gamma linolenic acid with tamoxifen as primary therapy in breast cancer | Q62690554 | ||
Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats | Q66956915 | ||
Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation | Q68277142 | ||
Morphologic effects of sulfur-substituted fatty acids on rat hepatocytes with special reference to proliferation of peroxisomes and mitochondria | Q68636160 | ||
Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids | Q68740692 | ||
Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro | Q69051373 | ||
Regulation of mitochondrial hexokinase in cultured HT 29 human cancer cells. An ultrastructural and biochemical study | Q69201041 | ||
Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro | Q70191812 | ||
Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice | Q70508182 | ||
Effect of dietary 18-carbon fatty acids on growth of transplantable mammary adenocarcinomas in mice | Q70912141 | ||
Human and rat tumour cells possess mitochondrial carnitine palmitoyltransferase I and II: effects of insulin | Q70972594 | ||
Immunodetection of rat Walker 256 tumour mitochondrial carnitine palmitoyltransferase I and II: evidence for the control of CPT II expression by insulin | Q71809904 | ||
Local application of γ-linolenic acid in the treatment of human gliomas | Q71955431 | ||
Some effects of the essential fatty acids linoleic acid and alpha-linolenic acid and of their metabolites gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and of prostaglandins A1 and E1 on the proliferation of hu | Q72391246 | ||
Dietary fish oil inhibits human breast carcinoma growth: a function of increased lipid peroxidation | Q72583479 | ||
The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid | Q73026350 | ||
A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis | Q73112699 | ||
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2 | Q73156213 | ||
Metabolic fate and effects of saturated and unsaturated fatty acids in Hep2 human larynx tumor cells | Q73196630 | ||
Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells | Q73220540 | ||
Long chain fatty acids inhibit and medium chain fatty acids activate mammalian cardiac hexokinase | Q73665974 | ||
Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin | Q73960722 | ||
Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis | Q74292312 | ||
Effects of saturated and polyunsaturated fatty acids on human tumor-cell proliferation | Q74313776 | ||
Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells | Q74808877 | ||
Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma | Q44019169 | ||
Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. | Q44031573 | ||
Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells | Q44487395 | ||
Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure. | Q44499862 | ||
A Positive Role for the Ku Complex in DNA Replication Following Strand Break Damage in Mammals | Q44655898 | ||
Effects of polyunsaturated fatty acids on the efficacy of antineoplastic agents toward L5178Y lymphoma cells | Q46064678 | ||
Fatty acid oxidation and ketogenesis by astrocytes in primary culture | Q28573778 | ||
Homophilic anchorage of brain-hexokinase to mitochondria-porins revealed by specific-peptide antibody cross recognition | Q28577345 | ||
Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro | Q28579770 | ||
The mitochondrial permeability transition pore and its role in cell death | Q29614183 | ||
Mitochondria, oxidative stress and cell death | Q29618996 | ||
Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2 | Q30523968 | ||
Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis | Q31048542 | ||
Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells | Q31847628 | ||
Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes | Q33359079 | ||
Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells | Q33406013 | ||
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis | Q33623036 | ||
Omega-3 fatty acids as cancer chemopreventive agents | Q33781514 | ||
Putative partners in Bax mediated cytochrome-c release: ANT, CypD, VDAC or none of them? | Q33845721 | ||
Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors | Q33935153 | ||
Mitochondria as the central control point of apoptosis | Q33994978 | ||
The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence. | Q34428622 | ||
A radical approach to cancer. | Q34598467 | ||
Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. | Q34748661 | ||
Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity | Q34892751 | ||
Intracellular unesterified arachidonic acid signals apoptosis | Q35272311 | ||
The eicosanoid cascade: possible role in gliomas and meningiomas | Q35615457 | ||
From bench to the clinic: gamma-linolenic acid therapy of human gliomas | Q35761731 | ||
Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique | Q35900885 | ||
Role of mitochondria as the gardens of cell death | Q36263117 | ||
The biology of Ku and its potential oncogenic role in cancer. | Q36397520 | ||
Colon cancer, fatty acids and anti-inflammatory compounds | Q36667582 | ||
Cardiolipin: setting the beat of apoptosis | Q36733690 | ||
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. | Q36733720 | ||
Dietary factors and growth and metabolism in experimental tumors | Q36785444 | ||
A pivotal role for p53: balancing aerobic respiration and glycolysis | Q36841610 | ||
Oxygen metabolism and a potential role for cytochrome c oxidase in the Warburg effect | Q36857455 | ||
Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. | Q36864009 | ||
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? | Q36877059 | ||
Hypoxia, glucose metabolism and the Warburg's effect. | Q36895405 | ||
Actuality of Warburg's views in our understanding of renal cancer metabolism. | Q36897159 | ||
Approaches to mitochondrially mediated cancer therapy | Q37059949 | ||
Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense | Q37107268 | ||
Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression | Q37140807 | ||
Mitochondria in cancer: not just innocent bystanders | Q37356276 | ||
Mitochondria as targets for cancer chemotherapy | Q37356281 | ||
Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer. | Q37364559 | ||
Bcl-2 family proteins as regulators of oxidative stress | Q37367025 | ||
Mitochondria as targets for chemotherapy | Q37389341 | ||
Tumor suppressors and cell metabolism: a recipe for cancer growth | Q37390879 | ||
Contact sites between mitochondrial envelope membranes. Structure and function in energy- and protein-transfer | Q37545051 | ||
Inhibition of Ku autoantigen binding activity to the E2F motif after ultraviolet B irradiation of melanocytic cells. | Q38329108 | ||
Migration patterns and breast cancer risk in Asian-American women | Q39403629 | ||
Enhancement of radiosensitivity by roscovitine pretreatment in human non-small cell lung cancer A549 cells | Q39946999 | ||
ShRNA-mediated Ku80 gene silencing inhibits cell proliferation and sensitizes to gamma-radiation and mitomycin C-induced apoptosis in esophageal squamous cell carcinoma lines | Q39993045 | ||
Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. | Q40007779 | ||
Relative biological effectiveness of high-energy iron ions for micronucleus formation at low doses. | Q40034073 | ||
Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysis | Q40303940 | ||
Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells | Q40403810 | ||
Role of NF-kappaB and DNA repair protein Ku on apoptosis in pancreatic acinar cells | Q40576228 | ||
Gamma-linolenic acid therapy of human gliomas | Q40595724 | ||
Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology | Q40688242 | ||
Mitochondrial matrix granules: their behavior during changing metabolic situations and their relationship to contact sites between inner and outer mitochondrial membranes | Q40754109 | ||
Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. | Q40808335 | ||
Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells | Q40989169 | ||
Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism | Q41013100 | ||
Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. | Q41013535 | ||
Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | Q41058290 | ||
Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. | Q41065069 | ||
Effects of gamma-linolenic acid and arachidonic acid on cell cycle progression and apoptosis induction in normal and transformed cells | Q41118106 | ||
Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill | Q41124254 | ||
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis | Q41128299 | ||
Fatty acid regulation of breast cancer cell growth and invasion | Q41636856 | ||
Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation | Q41692976 | ||
Cholate extracts of mitochondrial outer membranes increase inhibition by malonyl-CoA of carnitine palmitoyltransferase-I by a mechanism involving phospholipids | Q42009576 | ||
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis | Q42158235 | ||
Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells | Q42436788 | ||
Evidence for an impaired long-chain fatty acid oxidation and ketogenesis in Fao hepatoma cells | Q42453431 | ||
Intracellular oxidation by human glioma cell populations: effect of arachidonic acid | Q42459668 | ||
Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects. | Q42470568 | ||
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis | Q42601114 | ||
Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes | Q42818218 | ||
Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria | Q42989018 | ||
Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid | Q43002778 | ||
Cellular energetic metabolism of cerebral tissue: metabolic characteristics of glial tumours | Q43507484 | ||
Distinct kinetics of carnitine palmitoyltransferase i in contact sites and outer membranes of rat liver mitochondria | Q43556701 | ||
Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid | Q43593613 | ||
Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process | Q43600427 | ||
Rat liver mitochondrial contact sites and carnitine palmitoyltransferase-I. | Q43697833 | ||
gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells | Q43814331 | ||
P433 | issue | 1 | |
P921 | main subject | cell death | Q2383867 |
lipid | Q11367 | ||
mitochondrion | Q39572 | ||
P304 | page(s) | 76-88 | |
P577 | publication date | 2010-04-29 | |
P1433 | published in | Molecular Neurobiology | Q15716645 |
P1476 | title | Lipids, mitochondria and cell death: implications in neuro-oncology | |
P478 | volume | 42 |
Q38130894 | Antidepressant drugs as a complementary therapeutic strategy in cancer |
Q38960367 | Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: cellular, biochemical and gene expression analysis. |
Q37999099 | Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases |
Q38235840 | Inborn errors of metabolism underlying primary immunodeficiencies |
Q37456820 | Lyophilized brain tumor specimens can be used for histologic, nucleic acid, and protein analyses after 1 year of room temperature storage. |
Q37029575 | Modulation of methylmercury uptake by methionine: prevention of mitochondrial dysfunction in rat liver slices by a mimicry mechanism |
Q38733049 | Nuclear transport: a switch for the oxidative stress-signaling circuit? |
Q33748476 | Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathways |
Q37988008 | Therapeutic implications of disorders of cell death signalling: membranes, micro-environment, and eicosanoid and docosanoid metabolism |
Q33907375 | Vitamin E: a dark horse at the crossroad of cancer management |
Search more.