Viral tricks to grid-lock the type I interferon system

scientific article published on 10 June 2010

Viral tricks to grid-lock the type I interferon system is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.MIB.2010.05.009
P8608Fatcat IDrelease_bcj7p4yh6vatbazskyssi2rp6a
P932PMC publication ID2920345
P698PubMed publication ID20538505
P5875ResearchGate publication ID44663992

P50authorAdolfo García-SastreQ4684232
Gijs A VersteegQ54438384
P2860cites workZ proteins of New World arenaviruses bind RIG-I and interfere with type I interferon inductionQ22001518
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunityQ24296473
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusQ24311228
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IQ24312113
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateQ24315639
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathwayQ24317317
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseQ24317784
Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-IQ24336258
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoterQ24558779
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathwayQ24563231
GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVSQ24675888
Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonistQ27472136
Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated MechanismQ27473235
La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian HostsQ27480353
Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virusQ27481222
Interferon-inducible antiviral effectorsQ27486790
Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput ScreenQ27486814
Identification of Hepatitis C Virus NS5A InhibitorsQ27490539
The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT SignalingQ27491054
Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea PigsQ27658947
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activityQ28295453
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceQ28609778
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasuresQ29615028
Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseQ29616156
The AIM2 inflammasome is critical for innate immunity to Francisella tularensisQ29622833
Novel influenza virus NS1 antagonists block replication and restore innate immune functionQ30439074
Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccinesQ33294059
Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expressionQ33383235
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylationQ33406230
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compoundsQ33508889
Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.Q33707477
Cytopathogenesis and inhibition of host gene expression by RNA virusesQ34010277
Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replicationQ34717075
Influenza B virus NS1-truncated mutants: live-attenuated vaccine approachQ34820655
Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virusQ34999702
Cleavage of IPS-1 in cells infected with human rhinovirus.Q35001899
Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation.Q35002940
Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradationQ35036515
Dual functions of Rift Valley fever virus NSs protein: inhibition of host mRNA transcription and post-transcriptional downregulation of protein kinase PKR.Q35107614
The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanismQ35784635
The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.Q35900773
The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expressionQ36139348
Degradation of nuclear factor kappa B during foot-and-mouth disease virus infectionQ36315811
Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virusQ36484103
Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expressionQ37410858
A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 proteinQ37442279
Mucosal vaccines: novel advances in technology and deliveryQ37559647
Recognition of viruses by cytoplasmic sensorsQ37671348
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
Classical swine fever virus Erns glycoprotein antagonizes induction of interferon-beta by double-stranded RNA.Q39797106
Zinc binding in pestivirus N(pro) is required for interferon regulatory factor 3 interaction and degradation.Q39835627
Respiratory syncytial virus proteins modulate suppressors of cytokine signaling 1 and 3 and the type I interferon response to infection by a toll-like receptor pathwayQ39852751
A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic abilityQ39861100
Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate.Q39861118
Protein kinase R reveals an evolutionary model for defeating viral mimicryQ39910707
RNase-dependent inhibition of extracellular, but not intracellular, dsRNA-induced interferon synthesis by Erns of pestiviruses.Q39939094
Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activationQ39971611
Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway.Q40016479
Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signallingQ40044008
Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signalingQ40096640
A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesisQ40167332
Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonistsQ40208162
Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.Q40319046
Glycosylation of classical swine fever virus E(rns) is essential for binding double-stranded RNA and preventing interferon-beta inductionQ40378906
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenavirusesQ40491428
A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virusQ40508331
IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3.Q40674809
Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virusQ41847342
Differential inhibition of type I interferon induction by arenavirus nucleoproteinsQ41937252
Measles virus circumvents the host interferon response by different actions of the C and V proteins.Q42249885
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membraneQ42624738
Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinaseQ44539835
P58(IPK), a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis.Q52105752
The mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3Q57206555
Proteolytic Cleavage of the p65-RelA Subunit of NF-κB during Poliovirus InfectionQ58664420
P433issue4
P304page(s)508-516
P577publication date2010-06-10
P1433published inCurrent Opinion in MicrobiologyQ15752444
P1476titleViral tricks to grid-lock the type I interferon system
P478volume13

Reverse relations

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