Advances in targeting SRC in the treatment of breast cancer and other solid malignancies

scientific article published on July 2010

Advances in targeting SRC in the treatment of breast cancer and other solid malignancies is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1158/1078-0432.CCR-09-1834
P698PubMed publication ID20634194

P2093author name stringErica L Mayer
Ian E Krop
P2860cites workTargeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)3526-3532
P577publication date2010-07-01
P1433published inClinical Cancer ResearchQ332253
P1476titleAdvances in targeting SRC in the treatment of breast cancer and other solid malignancies
P478volume16

Reverse relations

cites work (P2860)
Q50041888A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424.
Q27335593A novel 3D fibril force assay implicates src in tumor cell force generation in collagen networks
Q36276485A phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer
Q37494943Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop
Q24300885Activation of rapid oestrogen signalling in aggressive human breast cancers
Q54610139Antihormone induced compensatory signalling in breast cancer: an adverse event in the development of endocrine resistance.
Q39108742Benzo-[a]-pyrene induces FAK activation and cell migration in MDA-MB-231 breast cancer cells
Q34658293Bosutinib plus capecitabine for selected advanced solid tumours: results of a phase 1 dose-escalation study
Q35995710C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway
Q41144896CXCL12/SDF-1α induces migration via SRC-mediated CXCR4-EGFR cross-talk in gastric cancer cells
Q39120121Caffeic acid regulates LPS-induced NF-κB activation through NIK/IKK and c-Src/ERK signaling pathways in endothelial cells
Q35992390Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signaling pathway
Q34100838Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
Q37338907Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
Q34708878Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells.
Q35919774Dasatinib enhances antitumor activity of paclitaxel in ovarian cancer through Src signaling
Q35050239Dasatinib in previously treated metastatic colorectal cancer: a phase II trial of the University of Chicago Phase II Consortium
Q39160945Dasatinib inhibits mammary tumour development in a genetically engineered mouse model
Q93350819Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells
Q28546078Data Mining Approaches for Genomic Biomarker Development: Applications Using Drug Screening Data from the Cancer Genome Project and the Cancer Cell Line Encyclopedia
Q26825584Development of new estrogen receptor-targeting therapeutic agents for tamoxifen-resistant breast cancer
Q58763841Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis
Q40196342Effect of selective small molecule inhibitors on MMP-9 and VEGFR-1 expression in p16-positive and -negative squamous cell carcinoma.
Q38965929Elucidation of epithelial-mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis.
Q38055272Emerging molecular targets in melanoma invasion and metastasis
Q38086421Emerging targeted agents in metastatic breast cancer
Q98665166Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis
Q36732781Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.
Q34972855From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond
Q37850683From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management
Q38989597Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.
Q36153325Identification of new candidate therapeutic target genes in triple-negative breast cancer
Q39434943Impact of the SRC inhibitor dasatinib on the metastatic phenotype of human prostate cancer cells
Q56962519Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells
Q37605645Integrative exploration of genomic profiles for triple negative breast cancer identifies potential drug targets.
Q91825069Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells
Q37672635Invading one step at a time: the role of invadopodia in tumor metastasis
Q41536100Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation.
Q35779175Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis
Q33786788Microenvironment, oncoantigens, and antitumor vaccination: lessons learned from BALB-neuT mice
Q57784935Monitoring Src status after dasatinib treatment in HER2+ breast cancer with Zr-trastuzumab PET imaging
Q39360651Multidrug-resistant cells overexpressing P-glycoprotein are susceptible to DNA crosslinking agents due to attenuated Src/nuclear EGFR cascade-activated DNA repair activity
Q36665708Novel therapies for the treatment of advanced prostate cancer
Q41425790Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer
Q41233146P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade
Q36290579Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts
Q54572400Phase I study of dasatinib (BMS-354825) in Japanese patients with solid tumors.
Q54114959Phase II Study of Paclitaxel and Dasatinib in Metastatic Breast Cancer.
Q24301920Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor
Q48505210Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer
Q28243770Regulation of SRC family kinases in human cancers
Q53352729Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma.
Q27016629Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies
Q49887894Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.
Q35803670SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer
Q37193756SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases.
Q55454920Src Plays an Important Role in AGE-Induced Endothelial Cell Proliferation, Migration, and Tubulogenesis.
Q41224540Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
Q46851492Src inhibition potentiates antitumoral effect of paclitaxel by blocking tumor-induced angiogenesis
Q49787703Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action
Q35371875Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival
Q47608480Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase
Q38700342Targeted Agents in Preclinical and Early Clinical Development for the Treatment of Cancer Bone Metastases
Q38009760Targeted therapy for triple-negative breast cancer: where are we?
Q27025646Targeting Src family kinases in anti-cancer therapies: turning promise into triumph
Q35640216Targeting invadopodia to block breast cancer metastasis
Q98466261Targeting the Extra-Cellular Matrix-Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors
Q38981265The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer
Q43184281The potential of Src inhibitors
Q30010212The regulation of N-methyl-D-aspartate receptors by Src kinase.
Q35149569The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma
Q64062159Therapeutic Targeting of Collective Invasion in Ovarian Cancer
Q37931268Therapeutic pipeline for soft-tissue sarcoma
Q38088419Tissue microarrays and quantitative tissue-based image analysis as a tool for oncology biomarker and diagnostic development
Q39614066Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy
Q83810300Trastuzumab resistance: all roads lead to SRC
Q88368631Treatment with Src inhibitor Dasatinib results in elevated metastatic potential in the 4T1 murine mammary carcinoma model
Q34125340Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration
Q30658863Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation
Q38772631UM-164: a potent c-Src/p38 kinase inhibitor with in vivo activity against triple negative breast cancer
Q34795271Unliganded estrogen receptor alpha promotes PC12 survival during serum starvation
Q90523430Unraveling the Cellular Mechanism of Assembling Cholesterols for Selective Cancer Cell Death
Q31103913Validation of the Cancer BioChip System as a 3D siRNA screening tool for breast cancer targets
Q54977387YAP/TAZ Activation as a Target for Treating Metastatic Cancer.
Q89746413YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression
Q96640911YES1 amplification confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive cancer
Q34472383p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.

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