| P50 | author | Angelika Vollmar | Q21253616 |
| P2093 | author name string | Karin von Schwarzenberg | |
| | Angelika M. Vollmar | |
| P2860 | cites work | The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress | Q24336121 |
| | Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B | Q28144420 |
| | The evolving role of natural products in drug discovery | Q28236671 |
| | Marine natural products and related compounds in clinical and advanced preclinical trials | Q28279168 |
| | Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL | Q28373965 |
| | Natural products as sources of new drugs over the last 25 years | Q29615119 |
| | Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. | Q30998417 |
| | Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro. | Q33216896 |
| | Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C | Q33651293 |
| | Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization | Q33752976 |
| | Immunosuppression by discodermolide. | Q34060413 |
| | New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica | Q34437864 |
| | A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib | Q34467271 |
| | Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules | Q34610473 |
| | Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors | Q34936117 |
| | Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents | Q35033904 |
| | Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications. | Q35157915 |
| | Bryostatin-1: a novel PKC inhibitor in clinical development | Q35634829 |
| | Progress in the clinical development of new marine-derived anticancer compounds. | Q35730063 |
| | IAPs, RINGs and ubiquitylation | Q36085601 |
| | A novel Apaf-1-independent putative caspase-2 activation complex | Q36324314 |
| | A novel proteasome inhibitor NPI-0052 as an anticancer therapy | Q36626591 |
| | The cephalostatin way of apoptosis | Q37079067 |
| | Panning for chemical gold: marine bacteria as a source of new therapeutics | Q37330830 |
| | Drug development from marine natural products | Q37354836 |
| | DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata | Q38352293 |
| | BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells | Q39790625 |
| | TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome | Q40207358 |
| | Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase | Q40351418 |
| | Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity | Q40386827 |
| | Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling. | Q40419018 |
| | Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria | Q40600446 |
| | Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization | Q40708852 |
| | Bax:Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh. | Q40916192 |
| | Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19. | Q41022616 |
| | Progress in the discovery of biosynthetic anticancer drugs | Q41101985 |
| | (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest | Q41207788 |
| | Synthesis and structure determination of kahalalide F (1,2). | Q43798351 |
| | Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis. | Q44116130 |
| | Mechanism of ascididemin-induced cytotoxicity | Q44316458 |
| | Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. | Q44481203 |
| | Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells. | Q44732833 |
| | Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m2 24 h or 1.3 mg/m2 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer. | Q45952578 |
| | A low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184. | Q47945996 |
| | Antitumor activity of TZT-1027, a novel dolastatin 10 derivative | Q48773255 |
| | (+)-discodermolide: a marine natural product against cancer. | Q53891476 |
| | Role of Smac in cephalostatin-induced cell death | Q57243490 |
| | Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9 | Q57274132 |
| | The Marine Product Cephalostatin 1 Activates an Endoplasmic Reticulum Stress-specific and Apoptosome-independent Apoptotic Signaling Pathway | Q59196834 |
| | Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-Phase Arrest and DNA Damage | Q59196838 |
| | Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix | Q59196852 |
| | A New, More Efficient, and Effective Process for the Synthesis of a Key Pentacyclic Intermediate for Production of Ecteinascidin and Phthalascidin Antitumor Agents | Q60450686 |
| | Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma | Q61781150 |
| | Calpain-1 Regulates Bax and Subsequent Smac-dependent Caspase-3 Activation in Neutrophil Apoptosis | Q61959790 |
| | The antitumoral compound Kahalalide F acts on cell lysosomes | Q62076248 |
| | Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain | Q68816801 |
| | Binding to DNA and cytotoxic evaluation of ascididemin, the major alkaloid from the Mediterranean ascidian Cystodytes dellechiajei | Q72326060 |
| | Isolation and structure of cephalostatins 10 and 11 | Q72364073 |
| | The in vivo effect of bryostatin-1 on paclitaxel-induced tumor growth, mitotic entry, and blood flow | Q73707452 |
| | Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells | Q73889069 |
| | Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells | Q73939323 |
| | Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp.(1) | Q74824079 |
| | Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification | Q77733277 |
| | Marine natural products: synthetic aspects | Q79702853 |
| | A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells | Q80286682 |
| | Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP | Q81441390 |
| | RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal | Q81833471 |
| | Investigation of the marine compound spongistatin 1 links the inhibition of PKCalpha translocation to nonmitotic effects of tubulin antagonism in angiogenesis | Q82839833 |
| | Enantioselective synthesis of (+)-cephalostatin 1 | Q84996458 |
| | Apoptosis regulating proteins as targets of therapy for haematological malignancies | Q93945659 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | apoptotic process | Q14599311 |
| P304 | page(s) | 295-303 | |
| P577 | publication date | 2010-07-31 | |
| P1433 | published in | Cancer Letters | Q326372 |
| P1476 | title | Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy | |
| | Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy | |
| P478 | volume | 332 | |