scholarly article | Q13442814 |
P50 | author | Tilman Grune | Q42577412 |
Kelvin J. A. Davies | Q56851069 | ||
P2093 | author name string | Annika Hoehn | |
Stefanie Grimm | |||
P2860 | cites work | B lymphocytes and neuroinvasion | Q95802945 |
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions | Q22009563 | ||
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Q22254584 | ||
A role for alpha-synuclein in the regulation of dopamine biosynthesis | Q24293727 | ||
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 | ||
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress | Q24338241 | ||
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration | Q24532130 | ||
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility | Q24532227 | ||
Pathways towards and away from Alzheimer's disease | Q24596270 | ||
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans | Q27314537 | ||
IARC scientific publications | Q27714811 | ||
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease | Q27860459 | ||
A C. elegans mutant that lives twice as long as wild type | Q27861054 | ||
Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins | Q28168105 | ||
Huntingtin aggregation and toxicity in Huntington's disease | Q28204163 | ||
Regulation of synaptophysin degradation by mammalian homologues of seven in absentia | Q28215219 | ||
The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts | Q28242143 | ||
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia | Q28250989 | ||
Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity | Q28254530 | ||
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases | Q28269333 | ||
Ubiquitin-independent degradation of proteins by the proteasome | Q28284043 | ||
Neurodegenerative disease: neuron protection agency | Q28287753 | ||
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis | Q28587044 | ||
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals | Q28587714 | ||
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system | Q28594502 | ||
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia | Q29547174 | ||
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease | Q29547175 | ||
Mitochondria, oxidants, and aging | Q29547594 | ||
Impairment of the ubiquitin-proteasome system by protein aggregation | Q29614556 | ||
Chronic systemic pesticide exposure reproduces features of Parkinson's disease | Q29614763 | ||
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging | Q29616056 | ||
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases | Q29616535 | ||
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology | Q29617284 | ||
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease | Q29617286 | ||
Oxidative stress and neurodegeneration: where are we now? | Q29617324 | ||
A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. | Q36880536 | ||
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates | Q37003482 | ||
Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases | Q37066195 | ||
Animal models of Alzheimer's disease and frontotemporal dementia | Q37196122 | ||
Molecular mechanisms of alpha-synuclein neurodegeneration | Q37309838 | ||
The proteasomal system. | Q37446143 | ||
Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging. | Q37476033 | ||
Brain proteins that mind metals: a neurodegenerative perspective | Q37487639 | ||
Microglia and inflammation in Alzheimer's disease | Q37703295 | ||
Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage | Q37953680 | ||
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. | Q39173722 | ||
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells | Q39754366 | ||
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress | Q40238615 | ||
Protein oxidation and degradation during postmitotic senescence. | Q40363959 | ||
Free radicals and phagocytic cells. | Q40401665 | ||
Reactions of oxyl radicals with DNA. | Q40456587 | ||
Aging, energy, and oxidative stress in neurodegenerative diseases. | Q40478731 | ||
The complexity of DNA damage: relevance to biological consequences | Q40645372 | ||
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. | Q40649321 | ||
The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins. | Q40720516 | ||
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence | Q40839462 | ||
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts | Q40864003 | ||
Neutrophil signal transduction and activation of the respiratory burst | Q40866789 | ||
Decreased levels of proteasome activity and proteasome expression in aging spinal cord | Q40873171 | ||
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts | Q40888525 | ||
Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype | Q41041671 | ||
Neuropathology of Parkinson's disease | Q41095404 | ||
Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease | Q41181063 | ||
Regional mitochondrial respiratory activity in Huntington's disease brain | Q41360902 | ||
Oxidative stress hypothesis in Alzheimer's disease | Q41482152 | ||
Iron homeostasis, oxidative stress, and DNA damage | Q41593783 | ||
Comparative resistance of the 20S and 26S proteasome to oxidative stress. | Q42159087 | ||
Protein damage and degradation by oxygen radicals. II. Modification of amino acids | Q42206650 | ||
Reduced levels of oxidized and glycoxidized proteins in human fibroblasts exposed to repeated mild heat shock during serial passaging in vitro | Q42514222 | ||
The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species. | Q42514984 | ||
Defining neurodegenerative diseases | Q42778432 | ||
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits | Q43556693 | ||
Mitochondrial abnormalities in Alzheimer's disease. | Q43581697 | ||
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils | Q43718666 | ||
Tripeptidyl-peptidase I in neuronal ceroid lipofuscinoses and other lysosomal storage disorders | Q43758146 | ||
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein | Q43798526 | ||
Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease | Q43830045 | ||
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease | Q44013447 | ||
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). | Q44111677 | ||
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease | Q44365109 | ||
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases | Q44727052 | ||
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. | Q44728755 | ||
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations | Q44931294 | ||
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. | Q45057099 | ||
Understanding the odd science of aging | Q29617341 | ||
Oxidative stress in Parkinson's disease | Q29618017 | ||
The free radical theory of aging matures | Q29618019 | ||
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease | Q31132651 | ||
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein | Q32035009 | ||
Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain. | Q32065904 | ||
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins. | Q33199152 | ||
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein | Q33470625 | ||
Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport | Q33476856 | ||
The role of excitotoxicity in neurodegenerative disease: implications for therapy | Q33639170 | ||
Phosphorylation of proteasomes in mammalian cells | Q33654836 | ||
Molecular basis of the neurodegenerative disorders | Q33667722 | ||
Oxidative stress and Alzheimer disease | Q33841850 | ||
Mechanisms of tau-induced neurodegeneration | Q33859830 | ||
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. | Q33941736 | ||
Energetics in the pathogenesis of neurodegenerative diseases | Q33944937 | ||
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease | Q33947152 | ||
Deamidation of human proteins | Q33947742 | ||
Protein oxidation. | Q33948086 | ||
Protein degradation by the proteasome and its implications in aging | Q33981592 | ||
Methionine oxidation and aging | Q33984659 | ||
Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology | Q33998664 | ||
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid | Q34011426 | ||
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. | Q34082498 | ||
Amyloid precursors and amyloidosis in inflammatory arthritis | Q34124988 | ||
Protein oxidation and aging | Q34243989 | ||
The role of AGEs in aging: causation or correlation | Q34348813 | ||
The cellular prion protein binds copper in vivo | Q34450742 | ||
Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? | Q34535129 | ||
Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses | Q34562951 | ||
Carbonyl modified proteins in cellular regulation, aging, and disease | Q34615822 | ||
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis | Q34736976 | ||
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses | Q34831241 | ||
Oxidative stress and nitration in neurodegeneration: cause, effect, or association? | Q35047296 | ||
Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers | Q35085041 | ||
Oxidative stress biomarkers in sporadic ALS | Q35094635 | ||
Alzheimer's disease and Parkinson's disease | Q35097797 | ||
Apoptosis and caspases in neurodegenerative diseases | Q35097801 | ||
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease | Q35166007 | ||
Molecular mechanisms of amyloidosis | Q35194628 | ||
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? | Q35254212 | ||
Advanced Maillard reaction end products are associated with Alzheimer disease pathology | Q35527031 | ||
alpha-synuclein promotes mitochondrial deficit and oxidative stress | Q35745729 | ||
Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases | Q35753534 | ||
Role of oxidant species in aging | Q35768371 | ||
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. | Q35869405 | ||
Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD). | Q36135523 | ||
Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis | Q36161189 | ||
Proteasome function in aging and oxidative stress: implications in protein maintenance failure | Q36399809 | ||
Oxidized protein degradation and repair in ageing and oxidative stress. | Q36435977 | ||
The molecular pathology of Alzheimer's disease | Q36490940 | ||
Catabolic insufficiency and aging | Q36520931 | ||
Protein modification in aging: an update | Q36606502 | ||
Oxidative damage in Huntington's disease pathogenesis | Q36620593 | ||
Biochemistry of amino acid racemization and clinical application to musculoskeletal disease | Q36626182 | ||
Mitochondrial DNA damage and the aging process: facts and imaginations. | Q36647425 | ||
Lipofuscin-like fluorophores originated from malondialdehyde | Q36647442 | ||
Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron | Q36738248 | ||
Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study | Q36745703 | ||
Biological aging is no longer an unsolved problem | Q36802089 | ||
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins | Q36843138 | ||
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. | Q36880531 | ||
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases | Q45230472 | ||
Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment | Q45233001 | ||
Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse. | Q45299682 | ||
Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease | Q45300303 | ||
Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia. | Q46004513 | ||
The oxidative neurotoxicity of clioquinol | Q46579038 | ||
Tyrosine modification by reactive nitrogen species: a closer look | Q46738125 | ||
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease | Q46761473 | ||
Total antioxidant capacity is impaired in different structures from aged rat brain | Q46812097 | ||
Aging-related oxidative stress in healthy humans | Q46913238 | ||
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein | Q48325566 | ||
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease | Q48353748 | ||
Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. | Q48482071 | ||
Morphological alterations of the synapses in the locus coeruleus in Parkinson's disease. | Q48510496 | ||
Neurodegenerative disease: amyloid pores from pathogenic mutations. | Q48544171 | ||
The molecular and genetic basis of AD: the end of the beginning: the 2000 Wartenberg lecture. | Q48579960 | ||
Advances fuel Alzheimer's conundrum. | Q48601495 | ||
Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease. | Q48708325 | ||
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. | Q48910103 | ||
Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation? | Q49019886 | ||
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. | Q52209534 | ||
Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease | Q52238047 | ||
Impaired glutathione peroxidase activity accounts for the age-related accumulation of hydrogen peroxide in activated human neutrophils. | Q52243066 | ||
Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells. | Q52701159 | ||
beta-amyloid is different in normal aging and in Alzheimer disease. | Q53271609 | ||
The cellular prion protein binds copper in vivo | Q56058857 | ||
Parkinson's disease | Q56877819 | ||
In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease | Q57342096 | ||
Adult neuronal ceroid lipofuscinosis with palmitoyl-protein thioesterase deficiency: First adult-onset patients of a childhood disease | Q57394776 | ||
Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse | Q57877823 | ||
The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction† | Q58842885 | ||
Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Q59048476 | ||
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells | Q60284685 | ||
Renal amyloidosis following tuberculosis | Q64360746 | ||
Trinucleotide repeat expansion and human disease | Q71576495 | ||
Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons | Q71748788 | ||
Advanced glycation endproducts in ageing and Alzheimer's disease | Q73138940 | ||
Age-associated changes of superoxide dismutase and catalase activities in the rat brain | Q73145963 | ||
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress | Q73699336 | ||
Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells | Q73810247 | ||
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite | Q73829106 | ||
Primary systemic amyloidosis with delayed progression to multiple myeloma | Q74468989 | ||
Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading | Q77754821 | ||
Analysis of oxidized and nitrated proteins in plasma and tissues as biomarkers for exposure to reactive oxygen and nitrogen species | Q78669039 | ||
Mitochondrial dysfunction in amyotrophic lateral sclerosis also affects skeletal muscle | Q83208654 | ||
Lewy body dementia | Q84012227 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | post-translational protein modification | Q898362 |
neurodegeneration | Q1755122 | ||
P304 | page(s) | 73-88 | |
P577 | publication date | 2010-09-06 | |
P1433 | published in | Free Radical Research | Q5500025 |
P1476 | title | Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease | |
Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease | |||
P478 | volume | 45 |
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