Biochemical and cellular functions of P4 ATPases.

scientific article published on October 2010

Biochemical and cellular functions of P4 ATPases. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ20100644
P698PubMed publication ID20836764

P50authorStan F van de GraafQ42266905
P2093author name stringLeo W J Klomp
Lieke M van der Velden
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Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocasesQ24515245
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P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegansQ27312100
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Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi functionQ27930668
The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPasesQ27930841
An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar systemQ27932606
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A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiaeQ27933551
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The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeastQ27935783
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologuesQ27935807
DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiaeQ27935888
Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiaeQ27935929
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesiclesQ27936105
Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry.Q27936267
The Arf activator Gea2p and the P-type ATPase Drs2p interact at the Golgi in Saccharomyces cerevisiaeQ27937289
Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membraneQ27937489
Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo functionQ27937731
Transbilayer phospholipid flipping regulates Cdc42p signaling during polarized cell growth via Rga GTPase-activating proteinsQ27937809
A subfamily of P-type ATPases with aminophospholipid transporting activityQ27938647
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosisQ27939868
Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathwayQ27939959
Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeastQ27940028
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Characterization of mutations in ATP8B1 associated with hereditary cholestasisQ28270588
Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipidQ28282149
Familial intrahepatic cholestasis 1: studies of localization and functionQ28577318
Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesisQ28589024
A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilizationQ28592533
ATP8B1 is essential for maintaining normal hearingQ28593592
How lipid flippases can modulate membrane structureQ29030419
Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeastQ29143446
Membrane recognition by phospholipid-binding domainsQ29614848
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Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase.Q30483607
Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT.Q30484771
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An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocasesQ33373524
Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA alpha-subunitQ33522346
Gender influences monoallelic expression of ATP10A in human brainQ33697249
A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome.Q33944509
Identification of a functional role for lipid asymmetry in biological membranes: Phosphatidylserine-skeletal protein interactions modulate membrane stabilityQ34011716
Regulation of transbilayer plasma membrane phospholipid asymmetryQ34176163
Evolution of substrate specificities in the P-type ATPase superfamily.Q34451276
Lipid traffic: floppy drives and a superhighway.Q34555516
Biochemistry of Na,K-ATPaseQ34667442
On the origin of lipid asymmetry: the flip side of ion transportQ34709212
Association study of the 15q11-q13 maternal expression domain in Japanese autistic patientsQ34734544
Novel therapeutic applications of cardiac glycosidesQ34864765
Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactionsQ35116324
Molecular mechanisms of Na/K-ATPase-mediated signal transductionQ35134771
Yeast P4-ATPases Drs2p and Dnf1p are essential cargos of the NPFXD/Sla1p endocytic pathway.Q35613387
Flippases and vesicle-mediated protein transportQ35963094
Membrane binding domainsQ36103518
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintainedQ36228334
ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changesQ36262789
Phosphatidic acid- and phosphatidylserine-binding proteinsQ36453653
Continued functioning of the secretory pathway is essential for ribosome synthesisQ36650192
P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomesQ36796829
Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growthQ36817975
Scrambling of phospholipids activates red cell membrane cholesterolQ36869507
Biochemical aspects of active transportQ37079237
Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterolQ37137436
Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue.Q37225977
Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2pQ37258619
Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation.Q37264023
Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeastQ37377313
Mechanism and significance of P4 ATPase-catalyzed lipid transport: lessons from a Na+/K+-pump.Q37398214
Linking phospholipid flippases to vesicle-mediated protein transportQ37415007
The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptorQ37415558
Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranesQ37432087
Static and dynamic lipid asymmetry in cell membranesQ37632257
Identification of an overexpressed yeast gene which prevents aminoglycoside toxicityQ38350918
Membrane phosphatidylserine regulates surface charge and protein localizationQ40026492
Identification of a pool of non-pumping Na/K-ATPaseQ40171787
Lipid specific activation of the murine P4-ATPase Atp8a1 (ATPase II).Q40291896
A Chinese hamster ovary cell mutant defective in the non-endocytic uptake of fluorescent analogs of phosphatidylserine: isolation using a cytosol acidification protocolQ41362862
The effect of membrane cholesterol content on ion transport processes in plasma membranesQ41387625
Regulation of a Golgi flippase by phosphoinositides and an ArfGEF.Q42114351
Liver disease without flipping: new functions of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1.Q42555152
Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11aQ42742534
A P4-ATPase protein interaction network reveals a link between aminophospholipid transport and phosphoinositide metabolismQ43228014
Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate.Q43240642
Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient miceQ44462577
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistanceQ44599854
Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol.Q46080391
The Arabidopsis P4-ATPase ALA3 localizes to the golgi and requires a beta-subunit to function in lipid translocation and secretory vesicle formation.Q46085133
Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): evidence for heterogeneityQ46427713
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry.Q46626790
ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activityQ46941494
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)1-11
P577publication date2010-10-01
P1433published inBiochemical JournalQ864221
P1476titleBiochemical and cellular functions of P4 ATPases
P478volume431

Reverse relations

cites work (P2860)
Q28591671ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
Q37906517Flipping and flopping--lipids on the move
Q33694762Lipid flippase modulates olfactory receptor expression and odorant sensitivity in Drosophila
Q26741596P4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas
Q37940636Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome
Q36062197Proteomic Analysis of the Rat Canalicular Membrane Reveals Expression of a Complex System of P4-ATPases in Liver
Q35126655The Drosophila melanogaster phospholipid flippase dATP8B is required for odorant receptor function
Q38104257Where do they come from and where do they go: candidates for regulating extracellular vesicle formation in fungi

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