Leptospira as an Emerging Pathogen: A Review of its Biology, Pathogenesis and Host Immune Responses

scientific article published on September 1, 2010

Leptospira as an Emerging Pathogen: A Review of its Biology, Pathogenesis and Host Immune Responses is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2217/FMB.10.102
P953full work available at URLhttps://europepmc.org/articles/pmc3037011?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20860485/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20860485/?tool=EBI
http://www.futuremedicine.com/doi/abs/10.2217/fmb.10.102
https://europepmc.org/articles/PMC3037011
https://europepmc.org/articles/PMC3037011?pdf=render
https://doi.org/10.2217/fmb.10.102
https://www.tandfonline.com/doi/pdf/10.2217/fmb.10.102
P932PMC publication ID3037011
P698PubMed publication ID20860485
P5875ResearchGate publication ID46402533

P50authorJenifer CoburnQ88618669
P2093author name stringKaren V. Evangelista
P2860cites workMultilocus sequence typing method for identification and genotypic classification of pathogenic Leptospira speciesQ21245786
Genome sequence of the Brown Norway rat yields insights into mammalian evolutionQ22122498
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencingQ22122500
Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogansQ24537627
LfhA, a novel factor H-binding protein of Leptospira interrogansQ24547681
LeptospirosisQ24550687
Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogenQ24597151
Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesisQ24631126
Spirochaetal lipoproteins and pathogenesisQ24648165
Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogenQ24672690
A newly identified leptospiral adhesin mediates attachment to lamininQ24673674
Genome reduction in Leptospira borgpetersenii reflects limited transmission potentialQ24676664
Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infectionQ24678737
Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissuesQ27306865
Crystal structure of invasin: a bacterial integrin-binding proteinQ27619937
Virulence in leptospira. II. The growth in vivo of virulent Leptospira icterohaemorrhagiaeQ40246139
Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cellsQ40360026
Outbreak of leptospirosis among Adventure Race participants in Florida, 2005.Q40366540
MSCRAMM-mediated adherence of microorganisms to host tissues.Q40572996
Epidemiological trend of human leptospirosis in Italy between 1994 and 1996.Q40622654
Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastinQ41811666
Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infectionQ42118872
Lsa63, a newly identified surface protein of Leptospira interrogans binds laminin and collagen IV.Q43744895
Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeriQ44360287
Outbreak of acute febrile illness among athletes participating in triathlons--Wisconsin and Illinois, 1998.Q44517754
Cell aggregation: a mechanism of pathogenic Leptospira to survive in fresh waterQ44923221
Leptospiral TlyC is an extracellular matrix-binding protein and does not present hemolysin activityQ45258159
A monoclonal antibody reacting with a determinant on leptospiral lipopolysaccharide protects guinea pigs against leptospirosisQ46920822
Leptospiral immunoglobulin-like proteins elicit protective immunity.Q47823063
Use of a monovalent leptospiral vaccine to prevent renal colonization and urinary shedding in cattle exposed to Leptospira borgpetersenii serovar hardjoQ49199069
Evaluation of the expression and protective potential of Leptospiral sphingomyelinases.Q50595307
Biofilm formation by saprophytic and pathogenic leptospires.Q51689013
A severe case of leptospirosis acquired during an iron man contest.Q52965036
LeptospirosisQ54006882
Genetic manipulation of Leptospira biflexa.Q54417209
Whole-genome analysis of Leptospira interrogans to identify potential vaccine candidates against leptospirosis.Q54489788
The role of macrophages in the protection of mice against leptospirosis: in vitro and in vivo studies.Q54511717
Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogansQ56376383
TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogansQ56772146
Outbreak of Leptospirosis among Triathlon Participants and Community Residents in Springfield, Illinois, 1998Q59230828
First isolation of bacteriophages for a spirochaete: potential genetic tools for LeptospiraQ70281385
Identification of a 36-kDa fibronectin-binding protein expressed by a virulent variant of Leptospira interrogans serovar icterohaemorrhagiaeQ73580629
Morphological characterization of lung and kidney lesions in C3H/HeJ mice infected with Leptospira interrogans serovar icterohaemorrhagiae: defect of CD4+ and CD8+ T-cells are prognosticators of the disease progressionQ74816790
Sero-prevalence of leptospirosis in workers at a New Zealand slaughterhouseQ82861470
Philippines struggles to recover from typhoonsQ84851006
The changing epidemiology of leptospirosis in IsraelQ37075218
Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogansQ37099412
Global proteome analysis of Leptospira interrogansQ37375200
Leptospirosis: an emerging global public health problemQ37390241
Leptospira and leptospirosisQ37432687
A newly identified protein of Leptospira interrogans mediates binding to laminin.Q38353007
Leptospira interrogans binds to human cell surface receptors including proteoglycansQ38920516
Persistence of anti-leptospiral IgM, IgG and agglutinating antibodies in patients presenting with acute febrile illness in Barbados 1979-1989.Q38957708
Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study GroupQ39517679
Streptococcus-zebrafish model of bacterial pathogenesisQ39655603
Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.Q39820861
Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin.Q39827392
Immunogenicity and protective efficacy of recombinant Leptospira immunoglobulin-like protein B (rLigB) in a hamster challenge modelQ40019697
A domain of the Leptospira LigB contributes to high affinity binding of fibronectinQ40091911
Presence of putative sphingomyelinase genes among members of the family LeptospiraceaeQ40146360
Copurification of Leptospira interrogans serovar pomona hemolysin and sphingomyelinase C.Q40161582
Isolation and characterization of FecA- and FeoB-mediated iron acquisition systems of the spirochete Leptospira biflexa by random insertional mutagenesisQ33755272
Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposonQ33755278
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogenQ33826140
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.Q33940165
First evidence for gene replacement in Leptospira spp. Inactivation of L. biflexa flaB results in non-motile mutants deficient in endoflagellaQ33942114
The LE1 bacteriophage replicates as a plasmid within Leptospira biflexa: construction of an L. biflexa-Escherichia coli shuttle vectorQ33994686
Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection.Q34002814
Lethal infection of C3H/HeJ and C3H/SCID mice with an isolate of Leptospira interrogans serovar copenhageniQ34033461
Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humansQ34047498
Quantitative PCR assay to evaluate ampicillin, ofloxacin, and doxycycline for treatment of experimental leptospirosisQ34113749
Leptospirosis: a zoonotic disease of global importanceQ34280573
Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burdenQ34334413
Leptospirosis in "Eco-Challenge" athletes, Malaysian Borneo, 2000.Q34396402
Host immunological mechanisms in the resistance of mice to leptospiral infectionsQ34411319
Inactivation of the spirochete recA gene results in a mutant with low viability and irregular nucleoid morphologyQ34435394
Hamster model of leptospirosisQ34596742
Characterization of virulence of Leptospira isolates in a hamster modelQ34786061
Genetics of motility and chemotaxis of a fascinating group of bacteria: the spirochetesQ34995434
Effects of temperature on gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome microarrays.Q35073903
Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosisQ35096117
Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunityQ35217489
The molecular basis of fibronectin-mediated bacterial adherence to host cellsQ35752937
Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transitionQ35913426
The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosisQ36013519
LipL32 is an extracellular matrix-interacting protein of Leptospira spp. and Pseudoalteromonas tunicataQ36594078
Antimicrobial therapy of leptospirosisQ36639694
Lsa21, a novel leptospiral protein binding adhesive matrix molecules and present during human infection.Q36661539
In LipL32, the major leptospiral lipoprotein, the C terminus is the primary immunogenic domain and mediates interaction with collagen IV and plasma fibronectinQ36710705
Characterization of three putative Serpulina hyodysenteriae hemolysinsQ36727599
Leptospirosis: pathogenesis, immunity, and diagnosisQ36807338
Proteomic analysis of Leptospira interrogans shed in urine of chronically infected hosts.Q36949971
Targeted mutagenesis in pathogenic Leptospira species: disruption of the LigB gene does not affect virulence in animal models of leptospirosisQ36974427
The globalization of leptospirosis: worldwide incidence trends.Q37022589
Crystal structure of enteropathogenic Escherichia coli intimin-receptor complexQ27625285
Calcium Binds to LipL32, a Lipoprotein from Pathogenic Leptospira, and Modulates Fibronectin BindingQ27658382
A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogansQ30157215
The flagellar cytoskeleton of the spirochetes.Q30356930
Further determination of DNA relatedness between serogroups and serovars in the family Leptospiraceae with a proposal for Leptospira alexanderi sp. nov. and four new Leptospira genomospeciesQ30577074
Cytotoxic activities of Leptospira interrogans hemolysin SphH as a pore-forming protein on mammalian cellsQ30780506
Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamilyQ30815174
Conjugative transfer between Escherichia coli and Leptospira spp. as a new genetic toolQ30836279
The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infectionQ30847648
Identification and partial characterization of a novel hemolysin from Leptospira interrogans serovar lai.Q30918899
Leptospira spp. possess a complete haem biosynthetic pathway and are able to use exogenous haem sources.Q30963745
Comparative transcriptional and translational analysis of leptospiral outer membrane protein expression in response to temperatureQ30974956
Molecular cloning and characterization of a novel leptospiral lipoprotein with OmpA domainQ31010467
Molecular characterization of thermoinduced immunogenic proteins Q1p42 and Hsp15 of Leptospira interrogansQ31029837
Leptospira broomii sp. nov., isolated from humans with leptospirosisQ31033539
Host-inducible immunogenic sphingomyelinase-like protein, Lk73.5, of Leptospira interrogansQ31037865
Leptospira fainei sp. nov., isolated from pigs in AustraliaQ32023340
Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosisQ33212244
Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601.Q33246183
The OmpA-like protein Loa22 is essential for leptospiral virulenceQ33290833
Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complementQ33305446
Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosisQ33319579
Cytotoxic activity and probable apoptotic effect of Sph2, a sphigomyelinase hemolysin from Leptospira interrogans strain Lai.Q33322243
Calcium binds to leptospiral immunoglobulin-like protein, LigB, and modulates fibronectin bindingQ33351593
Genome-wide transposon mutagenesis in pathogenic Leptospira speciesQ33388640
Resurgence of field fever in a temperate country: an epidemic of leptospirosis among seasonal strawberry harvesters in Germany in 2007.Q33405589
Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogansQ33482787
Leptospirosis in the Asia Pacific regionQ33500335
Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai.Q33517849
Differential cytokine gene expression according to outcome in a hamster model of leptospirosisQ33524409
Osmolarity, a key environmental signal controlling expression of leptospiral proteins LigA and LigB and the extracellular release of LigA.Q33558602
A novel fibronectin type III module binding motif identified on C-terminus of Leptospira immunoglobulin-like protein, LigB.Q33584484
The C-terminal variable domain of LigB from Leptospira mediates binding to fibronectinQ33729857
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
emerging pathogenQ108429945
P1104number of pages13
P304page(s)1413-1425
P577publication date2010-09-01
P1433published inFuture MicrobiologyQ15759961
P1476titleLeptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses
Leptospira as an Emerging Pathogen: A Review of its Biology, Pathogenesis and Host Immune Responses
P478volume5

Reverse relations

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