Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

scientific article published on 25 September 2010

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00125-010-1896-4
P698PubMed publication ID20871975
P5875ResearchGate publication ID46428344

P50authorJens Juul HolstQ28373106
Carolyn F. DeaconQ55446060
P2093author name stringI Vardarli
M A Nauck
J J Meier
P2860cites workGut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1Q24682766
Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humansQ27865308
Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetesQ28212600
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120Q28507400
Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and manQ28609252
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.Q33225025
DPP-4 inhibitorsQ33308406
Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginineQ34180164
Attenuated GLP-1 secretion in obesity: cause or consequence?Q34409856
Incretin hormones--an update.Q34443081
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjectsQ35121793
Gut hormones and diabetes mellitusQ35485201
Incretins and their analogues as new antidiabetic drugs.Q35605503
The potential role of glucagon-like peptide 1 in diabetes.Q35768007
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
Glucagon-like peptide 1 and its derivatives in the treatment of diabetes.Q36075988
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetesQ36293659
First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery.Q37105136
Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptidesQ71566137
Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loopQ72801428
Colocalization of GLP-1 and GIP in human and porcine intestineQ73476547
Exenatide pharmacokinetics in healthy Chinese subjectsQ81968924
Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes.Q37319199
Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequencesQ37562725
Gastric emptying and release of incretin hormones after glucose ingestion in humansQ39759027
Carbohydrate Digestion and AbsorptionQ39986385
Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetesQ41585674
GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cellQ42146257
Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: cholinergic control of GLP-1 secretion via muscarinic receptorsQ42435619
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjectsQ42436041
Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretionQ42469854
Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes.Q42520533
Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humansQ43054594
Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretionQ43259523
The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemiaQ43596007
Glucagon-like peptide-1 7-36: a physiological incretin in man.Q43623564
Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptorQ43687822
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patientsQ43705651
Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men.Q43720039
Differences in glucagon-like peptide-1 and GIP responses following sucrose ingestionQ43874494
Regulation of Intestinal Proglucagon- Derived Peptide Secretion by Intestinal Regulatory Peptides*Q44049052
Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjectsQ44081118
The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabeticsQ44111090
Enhanced secretion of glucagon-like peptide 1 by biguanide compoundsQ44207056
Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitusQ44467072
Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cellsQ44480669
Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileumQ44753726
Neural regulation of glucagon-like peptide-1 secretion in pigsQ45099394
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetesQ45112803
Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.Q45257473
Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitorsQ46368613
Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitusQ46653146
Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patientsQ46830628
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose toleranceQ46868130
Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36 amide) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in Type 2 diabetic patientsQ47956988
Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake.Q51492143
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.Q51550359
Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections.Q51582586
Physiological augmentation of amino acid-induced insulin secretion by GIP and GLP-I but not by CCK-8.Q51588717
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.Q51599426
Hypersecretion of truncated glucagon-like peptide-1 and gastric inhibitory polypeptide in obese patients.Q51602521
Reduced Incretin Effect in Type 2 DiabetesQ58168459
Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomyQ58449247
Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*Q58449399
Reduced incretin effect in type 2 (non-insulin-dependent) diabetesQ68865252
Voglibose (AO-128) is an efficient alpha-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserveQ70824569
Gastrin-releasing peptide is a novel mediator of proximal nutrient-induced proglucagon-derived peptide secretion from the distal gutQ71103325
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)10-18
P577publication date2010-09-25
P1433published inDiabetologiaQ5270140
P1476titleSecretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
P478volume54

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