New advancements and developments in treatment of renal cell carcinoma: focus on pazopanib

scientific article published on 05 October 2010

New advancements and developments in treatment of renal cell carcinoma: focus on pazopanib is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2147/OTT.S12480
P953full work available at URLhttps://europepmc.org/articles/PMC2962303
https://www.dovepress.com/getfile.php?fileID=7711
https://europepmc.org/articles/PMC2962303?pdf=render
P932PMC publication ID2962303
P698PubMed publication ID21049083
P5875ResearchGate publication ID270132132

P2093author name stringGuru Sonpavde
Thomas E. Hutson
C. Lance Cowey
P2860cites workExpression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.Q52939760
Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: an Eastern Cooperative Oncology Group/Intergroup trial.Q53657205
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumorsQ73263334
Tumor induction of VEGF promoter activity in stromal cellsQ77349243
Serum concentrations of VEGF and b-FGF in renal cell, prostate and urinary bladder carcinomasQ77364528
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.Q24540159
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitorQ27651145
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinomaQ28247085
Sunitinib versus interferon alfa in metastatic renal-cell carcinomaQ28282757
Sorafenib in advanced clear-cell renal-cell carcinomaQ28282767
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trialQ29615711
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trialQ29618031
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinomaQ29618608
Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphismQ33834417
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma.Q33880227
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survivalQ34021957
Cytokine therapy for metastatic renal cell carcinomaQ34251814
Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesisQ34327105
Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working group randomized trialQ34534574
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activityQ34580980
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trialQ34586436
Efficacy and safety of pazopanib in patients with metastatic renal cell carcinomaQ34614836
Role of VHL gene mutation in human cancerQ35990141
VEGF as a key mediator of angiogenesis in cancerQ36319024
Hypoxia-inducible factors, hypoxia, and tumor angiogenesisQ36433511
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206Q37117085
Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinomaQ37463922
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.Q39916513
Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohortQ44130026
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.Q44285254
Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgeryQ44398197
Phase I trial of pazopanib in patients with advanced cancer.Q45976168
Sequential sorafenib and sunitinib for renal cell carcinoma.Q46008845
Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesisQ47981361
VEGF induces hyperpermeability by a direct action on endothelial cells.Q48014396
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectrenal cell carcinomaQ1164529
P304page(s)147-155
P577publication date2010-10-05
P1433published inOncoTargets and TherapyQ7092081
P1476titleNew advancements and developments in treatment of renal cell carcinoma: focus on pazopanib
P478volume3

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