Microdosing: Current and The Future

scientific article published on March 1, 2010

Microdosing: Current and The Future is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4155/BIO.09.177
P953full work available at URLhttps://www.tandfonline.com/doi/pdf/10.4155/bio.09.177
P698PubMed publication ID21083258

P2093author name stringGraham Lappin
P2860cites workEffect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeysQ48638988
Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugsQ48665583
A fluvoxamine-caffeine interaction studyQ59915037
American College of Clinical Pharmacology position statement on the use of microdosing in the drug development processQ80050350
Commentary on ACCP position statement on the use of microdosing in the drug development processQ80119631
Evaluation of microdosing strategies for studies in preclinical drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose rangeQ80401257
Microdose clinical trial: quantitative determination of fexofenadine in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometryQ81097075
The utility of microdosing over the past 5 yearsQ82758165
Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjectsQ84582830
Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide.Q31945955
The use of in vitro methods to predict in vivo pharmacokinetics and drug interactionsQ34341646
Big physics, small doses: the use of AMS and PET in human microdosing of development drugsQ35075780
The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trialsQ36611045
Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humansQ36927601
A pharmacokinetic evaluation of five H(1) antagonists after an oral and intravenous microdose to human subjectsQ37173944
Single-dose escalation and multiple-dose safety, tolerability, and pharmacokinetics of IDX899, a candidate human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor, in healthy subjectsQ37190863
Microdosing: A Valuable Tool for Accelerating Drug Development and The Role of Bioanalytical Methods in Meeting The ChallengeQ37810137
New ultrasensitive detection technologies and techniques for use in microdosing studiesQ37810198
Microdosing in early lead discoveryQ37810233
Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humansQ40398090
The hepatic first-pass metabolism of problematic drugsQ40843463
Microdose clinical trial: quantitative determination of nicardipine and prediction of metabolites in human plasmaQ43278262
Microdosing assessment to evaluate pharmacokinetics and drug metabolism in rats using liquid chromatography-tandem mass spectrometry.Q46031834
Use of accelerator mass spectrometry to measure the pharmacokinetics and peripheral blood mononuclear cell concentrations of zidovudine.Q46125301
P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretionQ46430437
Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometryQ46834857
The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspectiveQ47819795
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)509-517
P577publication date2010-03-01
P1433published inBioanalysisQ18616741
P1476titleMicrodosing: current and the future
Microdosing: Current and The Future
P478volume2

Reverse relations

cites work (P2860)
Q86903943A microdose study of ¹⁴C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung
Q38186660Activating adaptive cellular mechanisms of resistance following sublethal cytotoxic chemotherapy: implications for diagnostic microdosing
Q48225243Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences.
Q51744154Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp
Q35687753Human Tissue in the Evaluation of Safety and Efficacy of New Medicines: A Viable Alternative to Animal Models?
Q39324948Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging.
Q38057372Induction of cytochrome P450 enzymes: a view on humanin vivofindings
Q39248701Intra-Target Microdosing (ITM): A Novel Drug Development Approach Aimed at Enabling Safer and Earlier Translation of Biological Insights Into Human Testing.
Q36287874Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates
Q38660826Metabolite profiling in early clinical drug development: current status and future prospects
Q88084113Microdosing Cocktail Assay Development for Drug-Drug Interaction Studies
Q35940544Microdosing and drug development: past, present and future
Q34802510Phase 0 trials: expediting the development of chemoprevention agents
Q40034799Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease
Q45348533Predicting drug candidate victims of drug-drug interactions, using microdosing
Q53099174Selected scientific topics of the 11th International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labeled Compounds
Q82313034Sensitive determination of a pharmaceutical compound and its metabolites in human plasma by ultra-high performance liquid chromatography–tandem mass spectrometry with on-line solid-phase extraction
Q42730808Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
Q50871327To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics

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