Regulation of ABC transporter function via phosphorylation by protein kinases

scientific article published on April 2011

Regulation of ABC transporter function via phosphorylation by protein kinases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.2174/138920111795164075
P932PMC publication ID3085954
P698PubMed publication ID21118091
P5875ResearchGate publication ID49645599

P2093author name stringChristian M Paumi
Elzbieta I Stolarczyk
Cassandra J Reiling
P2860cites workA gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasisQ22004274
A multidrug resistance transporter from human MCF-7 breast cancer cellsQ22008574
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiencyQ22010457
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transportersQ24290568
Large-scale characterization of HeLa cell nuclear phosphoproteinsQ24300834
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cellsQ24302137
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approachQ24321897
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
A quantitative atlas of mitotic phosphorylationQ24646817
Lipid A modification systems in gram-negative bacteriaQ24650951
The ABC protein turned chloride channel whose failure causes cystic fibrosisQ24657572
Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporterQ24681737
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulatorQ27642825
Global, in vivo, and site-specific phosphorylation dynamics in signaling networksQ27864128
Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)Q28117190
Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrinQ28118810
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNAQ28119124
Hepatic secretion of conjugated drugs and endogenous substancesQ28143763
The human ATP-binding cassette (ABC) transporter superfamilyQ28204495
ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)Q28217842
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndromeQ28240926
The gene responsible for adrenoleukodystrophy encodes a peroxisomal membrane proteinQ28243537
Mutation of the Stargardt disease gene (ABCR) in age-related macular degenerationQ28248752
The regulation of protein phosphorylationQ28252420
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometryQ28266730
The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesisQ28267290
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cellsQ28267574
A view of sur/KIR6.X, KATP channelsQ28268746
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosisQ28486471
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in miceQ28486845
Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-IQ28593742
Phosphorylation of the multidrug resistance associated glycoprotein.Q54397200
Effects of microcystin–LR on the expression of P-glycoprotein in Jenynsia multidentataQ57908308
Functional diversification of closely related ARF-GEFs in protein secretion and recyclingQ57933110
Evaluation of the Low-Specificity Protease Elastase for Large-Scale Phosphoproteome AnalysisQ57985105
The mdrl gene, responsible for multidrug-resistance, codes for P-glycoproteinQ58449756
cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activationQ71670897
Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sitesQ72080906
Saccharomyces cerevisiae ABC proteins and their relevance to human health and diseaseQ77121370
Identification of phosphorylation sites in human MDR1 P-glycoproteinQ77121398
[ABC transporters of pathogenic fungi: recent advances in functional analyses]Q81470138
Chronic PKC-beta2 activation in HT-29 Cl.19a colonocytes prevents cAMP-mediated ion secretion by inhibiting apical membrane CFTR targetingQ83019233
Phosphorylation of the cystic fibrosis transmembrane conductance regulatorQ28609248
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cellsQ28647106
Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channelsQ28910230
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancerQ29547564
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylationQ29615970
Biochemistry of multidrug resistance mediated by the multidrug transporterQ29616476
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signalingQ30444280
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domainQ32186098
Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporterQ33204214
Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.Q33285468
Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478Q33746958
Influence of phosphorylation by protein kinase A on CFTR at the cell surface and endoplasmic reticulumQ33784420
Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!Q33903142
The regulation of protein function by multisite phosphorylation--a 25 year updateQ33928103
Activity of the Kluyveromyces lactis Pdr5 multidrug transporter is modulated by the Sit4 protein phosphataseQ33996389
Fungal transporters involved in efflux of natural toxic compounds and fungicidesQ34012517
The human ATP-binding cassette (ABC) transporter superfamily.Q34083168
Regulation of the CFTR channel by phosphorylationQ34114162
The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulationQ34298925
ATP-binding cassette transporters in bacteriaQ34326023
Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews.Q34407812
Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebratesQ34446056
Overview: ABC transporters and human diseaseQ34502433
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.Q34559072
Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.Q34734854
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysisQ34741451
Overexpression, purification, and functional characterization of ATP-binding cassette transporters in the yeast, Pichia pastorisQ35066169
Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulatorQ35123086
Large-scale phosphorylation analysis of mouse liverQ35616333
Phosphatase inhibitors activate normal and defective CFTR chloride channelsQ35767286
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinasesQ35973264
Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transportersQ36153713
Identification of protein kinase A phosphorylation sites on NBD1 and R domains of CFTR using electrospray mass spectrometry with selective phosphate ion monitoringQ36280145
Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometryQ36280213
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceQ40050525
Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site.Q40173032
Differential phosphorylation patterns of P-glycoprotein reconstituted into a proteoliposome system: insight into additional unconventional phosphorylation sites.Q40347598
The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.Q40359721
Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cellsQ40387218
Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channelQ40566159
Multiple drug resistance in the pathogenic protozoaQ40623287
Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assemblyQ40638196
Peptide transporters and antigen processing.Q40654171
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.Q40708575
Differences in HAC1 mRNA processing and translation between yeast and mammalian cells indicate divergence of the eukaryotic ER stress responseQ40779656
Selective modulation of P-glycoprotein's ATPase and anion efflux regulation activities with PKC alpha and PKC epsilon in Sf9 cellsQ40846112
PKA-mediated phosphorylation of the human K(ATP) channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation.Q40931903
Identification of in vivo phosphorylation sites for basic-directed kinases in murine mdr1b P-glycoprotein by combination of mass spectrometry and site-directed mutagenesisQ41015246
Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein.Q41126580
Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells.Q41173821
GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cellsQ41449307
Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell linesQ41541755
Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulatorQ41661209
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis geneQ41669744
Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristineQ41690863
Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.Q41734532
Regulation of transporter associated with antigen processing by phosphorylation.Q41737446
Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein.Q41740850
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesisQ41788874
Mechanistic insight into control of CFTR by AMPK.Q41856265
Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoproteinQ41874604
NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.Q41882930
Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activityQ42061736
The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I moleculeQ42067167
Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometryQ42074039
Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteinsQ42610544
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodiesQ42806898
Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl- currents.Q42819789
Negative regulation of the yeast ABC transporter Ycf1p by phosphorylation within its N-terminal extensionQ43007858
Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR.Q43023020
Phosphoproteomic analysis of human embryonic stem cellsQ43069776
cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channelQ43089271
OpuC--an ABC transporter that is associated with Staphylococcus aureus pathogenesis.Q43255120
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycleQ43474246
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channelQ43911618
A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2).Q44185435
Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotidesQ44204475
Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.Q44317051
Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells.Q44534586
Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding.Q44542054
The internalization of yeast Ste6p follows an ordered series of events involving phosphorylation, ubiquitination, recognition and endocytosisQ44846212
The genetics of ATP-binding cassette transportersQ45108337
Phosphorylation of candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability.Q45119190
Ycf1-dependent cadmium detoxification by yeast requires phosphorylation of residues Ser908 and Thr911.Q45158242
Quantitative phosphoproteomics applied to the yeast pheromone signaling pathwayQ45234630
Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression systemQ45463762
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.Q46516304
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectraQ46959590
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal LectureQ48575949
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiaeQ50232146
Multi-xenobiotic-resistance a possible explanation for the insensitivity of bivalves towards cyanobacterial toxins.Q51676751
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.Q53938455
Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.Q53954489
Two-hybrid-based analysis of protein-protein interactions of the yeast multidrug resistance protein, Pdr5p.Q53973728
Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites.Q54226069
Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C.Q54245081
Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cellsQ54269732
Signaling networks assembled by oncogenic EGFR and c-MetQ36392991
Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domainQ36412577
Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.Q36412598
Regulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivationQ36444702
Fungal ATP-binding cassette (ABC) transporters in drug resistance & detoxificationQ36447057
PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance arteryQ36464471
PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptorsQ36482115
CFTR (ABCC7) is a hydrolyzable-ligand-gated channelQ36615006
A multidimensional chromatography technology for in-depth phosphoproteome analysisQ36804698
Pathogenicity and drug resistance in Candida albicans and other yeast species. A reviewQ36951859
Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.Q37188016
Large-scale proteomics analysis of the human kinomeQ37258113
AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.Q37264143
The meningococcal ABC-Type L-glutamate transporter GltT is necessary for the development of experimental meningitis in miceQ37333380
ABC transporters, drug resistance, and cancer stem cellsQ37395423
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamilyQ37451526
Application of LC/MS to proteomics studies: current status and future prospectsQ37476323
Multisite protein phosphorylation--from molecular mechanisms to kinetic modelsQ37479970
Inactivation of an ABC transporter gene, mcyH, results in loss of microcystin production in the cyanobacterium Microcystis aeruginosa PCC 7806.Q37597497
Phosphoproteomics--finally fulfilling the promise?Q37597911
Technologies for plasma membrane proteomics.Q37616097
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helicesQ37618800
Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoproteinQ38356826
Mutations affecting phosphorylation, ubiquitination and turnover of the ABC-transporter Ste6.Q38360938
Evolution of ATP-binding cassette transporter genesQ38562732
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactionsQ39811057
Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.Q39867307
Posttranslational regulation of Abcc2 expression by SUMOylation system.Q39906223
TiO(2)-based phosphoproteomic analysis of the plasma membrane and the effects of phosphatase inhibitor treatmentQ39968401
Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategyQ39980452
Functional modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylationQ40012344
P433issue4
P921main subjectphosphorylationQ242736
P304page(s)621-635
P577publication date2011-04-01
P1433published inCurrent Pharmaceutical BiotechnologyQ15763083
P1476titleRegulation of ABC transporter function via phosphorylation by protein kinases
P478volume12