Profile of belatacept and its potential role in prevention of graft rejection following renal transplantation

scientific article published on December 2010

Profile of belatacept and its potential role in prevention of graft rejection following renal transplantation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2147/DDDT.S10432
P932PMC publication ID2998809
P698PubMed publication ID21151624

P2093author name stringGaurav Gupta
Karl L Womer
P2860cites workImmunosuppression in vivo by a soluble form of the CTLA-4 T cell activation moleculeQ34298838
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation toleranceQ34448410
Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.Q34464636
Strategies to improve long-term outcomes after renal transplantationQ34539775
Five-year safety and efficacy of belatacept in renal transplantationQ34621558
The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantationQ34922215
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cellsQ36368842
Why hasn't eliminating acute rejection improved graft survival?Q36604328
Drug insight: maintenance immunosuppression in kidney transplant recipientsQ36662474
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.Q37256978
What's next in the pipelineQ37283960
Costimulatory pathways in transplantation: challenges and new developments.Q37474958
The pathogenesis and treatment of chronic allograft nephropathyQ37563986
Novel immunosuppressive agents in kidney transplantation.Q37737381
Belatacept in clinical and experimental transplantation - progress and promiseQ39869624
Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicityQ40084849
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.Q40459668
Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroidsQ43102233
A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).Q44247085
The natural history of chronic allograft nephropathyQ44688416
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T CellsQ46025217
Belatacept as maintenance immunosuppression for postrenal transplant de novo drug-induced thrombotic microangiopathyQ46177054
Prevention of calcineurin inhibitor nephrotoxicity in renal transplantationQ46346481
Costimulation blockade with belatacept in renal transplantationQ46569880
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathwaysQ46963324
Cardiovascular complications after renal transplantation and their prevention.Q50788889
Patient survival after renal transplantation; more than 25 years follow-up.Q50939199
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.Q51541351
Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation.Q51758531
Late onset Pneumocystis pneumonia in renal transplantation after long-term immunosuppression with belatacept.Q51826948
The OPTN/UNOS Renal Transplant Registry.Q51917732
Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunityQ56900861
Sirolimus Versus Cyclosporine in Kidney Recipients Receiving Thymoglobulin®, Mycophenolate Mofetil and a 6-Month Course of SteroidsQ56908156
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptorsQ56909582
Renal transplantationQ72442105
Induction of allograft tolerance through costimulatory blockade: first selection of drugs in vitroQ73508405
Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primatesQ74365181
Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantationQ78571274
Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4IgQ79290408
Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathwaysQ81227024
A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)Q84102539
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectimmunosuppressive drugQ249619
globulinsQ321710
blood proteinsQ425056
kidney transplantationQ740909
P304page(s)375-382
P577publication date2010-12-01
P1433published inDrug Design, Development and TherapyQ2566724
P1476titleProfile of belatacept and its potential role in prevention of graft rejection following renal transplantation
P478volume4

Reverse relations

cites work (P2860)
Q92538491An Inflammatory Story: Antibodies in Tuberculosis Comorbidities
Q30397952Desensitization: Overcoming the Immunologic Barriers to Transplantation
Q42727530Targets of new immunosuppressants in renal transplantation.
Q42281859Upregulation of microRNA 142-3p in the peripheral blood and urinary cells of kidney transplant recipients with post-transplant graft dysfunction
Q30486465What is the purpose of launching the World Journal of Transplantation?